TY - JOUR
T1 - FOXP3+ regulatory T cells in vulnerable atherosclerotic plaques
AU - de Boer, Onno J.
AU - van der Wal, Allard C.
PY - 2010
Y1 - 2010
N2 - Recently, Patel et al. reported that FOXP3 positive T cells are abundantly present in unstable atherosclerotic plaques. However, there is also evidence from immunohistochemical studies in humans, as well as experimental animal studies that their numbers are in fact relatively low. Since Treg are able to dampen tissue immune responses, their low numbers in plaques could be responsible for the ongoing inflammation that characterizes atherosclerosis
AB - Recently, Patel et al. reported that FOXP3 positive T cells are abundantly present in unstable atherosclerotic plaques. However, there is also evidence from immunohistochemical studies in humans, as well as experimental animal studies that their numbers are in fact relatively low. Since Treg are able to dampen tissue immune responses, their low numbers in plaques could be responsible for the ongoing inflammation that characterizes atherosclerosis
U2 - https://doi.org/10.1016/j.ijcard.2009.07.024
DO - https://doi.org/10.1016/j.ijcard.2009.07.024
M3 - Comment/Letter to the editor
C2 - 19703716
SN - 0167-5273
VL - 145
SP - 161
JO - International journal of cardiology
JF - International journal of cardiology
IS - 1
ER -