TY - JOUR
T1 - From Molecules to Imaging
T2 - Assessment of Placental Hypoxia Biomarkers in Placental Insufficiency Syndromes
AU - Al Darwish, Fatimah M.
AU - Meijerink, Lotte
AU - Coolen, Bram F.
AU - Strijkers, Gustav J.
AU - Bekker, Mireille
AU - Lely, Titia
AU - Terstappen, Fieke
N1 - Funding Information: This research was funded by ZonMw grant number (TRIPLET NWO 24434). Publisher Copyright: © 2023 by the authors.
PY - 2023/8/1
Y1 - 2023/8/1
N2 - Placental hypoxia poses significant risks to both the developing fetus and the mother during pregnancy, underscoring the importance of early detection and monitoring. Effectively identifying placental hypoxia and evaluating the deterioration in placental function requires reliable biomarkers. Molecular biomarkers in placental tissue can only be determined post-delivery and while maternal blood biomarkers can be measured over time, they can merely serve as proxies for placental function. Therefore, there is an increasing demand for non-invasive imaging techniques capable of directly assessing the placental condition over time. Recent advancements in imaging technologies, including photoacoustic and magnetic resonance imaging, offer promising tools for detecting and monitoring placental hypoxia. Integrating molecular and imaging biomarkers may revolutionize the detection and monitoring of placental hypoxia, improving pregnancy outcomes and reducing long-term health complications. This review describes current research on molecular and imaging biomarkers of placental hypoxia both in human and animal studies and aims to explore the benefits of an integrated approach throughout gestation.
AB - Placental hypoxia poses significant risks to both the developing fetus and the mother during pregnancy, underscoring the importance of early detection and monitoring. Effectively identifying placental hypoxia and evaluating the deterioration in placental function requires reliable biomarkers. Molecular biomarkers in placental tissue can only be determined post-delivery and while maternal blood biomarkers can be measured over time, they can merely serve as proxies for placental function. Therefore, there is an increasing demand for non-invasive imaging techniques capable of directly assessing the placental condition over time. Recent advancements in imaging technologies, including photoacoustic and magnetic resonance imaging, offer promising tools for detecting and monitoring placental hypoxia. Integrating molecular and imaging biomarkers may revolutionize the detection and monitoring of placental hypoxia, improving pregnancy outcomes and reducing long-term health complications. This review describes current research on molecular and imaging biomarkers of placental hypoxia both in human and animal studies and aims to explore the benefits of an integrated approach throughout gestation.
KW - molecular biomarkers
KW - non-invasive imaging
KW - placental hypoxia
UR - http://www.scopus.com/inward/record.url?scp=85168735578&partnerID=8YFLogxK
U2 - https://doi.org/10.3390/cells12162080
DO - https://doi.org/10.3390/cells12162080
M3 - Review article
C2 - 37626890
SN - 2073-4409
VL - 12
JO - Cells
JF - Cells
IS - 16
M1 - 2080
ER -