TY - JOUR
T1 - From system to organ to cell
T2 - Oxygenation and perfusion measurement in anesthesia and critical care
AU - Schober, Patrick
AU - Schwarte, Lothar A.
PY - 2012/8
Y1 - 2012/8
N2 - Maintenance or restoration of adequate tissue oxygenation is a main goal of anesthesiologic and intensive care patient management. Pathophysiological disturbances which interfere with aerobic metabolism may occur at any stage in the oxygen cascade from atmospheric gas to the mitochondria, and there is no single monitoring modality that allows comprehensive determination of "the oxygenation". To facilitate early detection of tissue hypoxia (or hyperoxia) and to allow a goal directed therapy targeted at the underlying problem, the anesthesiologist and intensive care physician require a thorough understanding of the numerous determinants that influence cellular oxygenation. This article reviews the basic physiology of oxygen uptake and delivery to tissues as well as the options to monitor determinants of oxygenation at different stages from the alveolus to the cell. © 2012 The Author(s).
AB - Maintenance or restoration of adequate tissue oxygenation is a main goal of anesthesiologic and intensive care patient management. Pathophysiological disturbances which interfere with aerobic metabolism may occur at any stage in the oxygen cascade from atmospheric gas to the mitochondria, and there is no single monitoring modality that allows comprehensive determination of "the oxygenation". To facilitate early detection of tissue hypoxia (or hyperoxia) and to allow a goal directed therapy targeted at the underlying problem, the anesthesiologist and intensive care physician require a thorough understanding of the numerous determinants that influence cellular oxygenation. This article reviews the basic physiology of oxygen uptake and delivery to tissues as well as the options to monitor determinants of oxygenation at different stages from the alveolus to the cell. © 2012 The Author(s).
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84865142676&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/22437884
U2 - https://doi.org/10.1007/s10877-012-9350-4
DO - https://doi.org/10.1007/s10877-012-9350-4
M3 - Article
C2 - 22437884
SN - 1387-1307
VL - 26
SP - 255
EP - 265
JO - Journal of clinical monitoring and computing
JF - Journal of clinical monitoring and computing
IS - 4
ER -