TY - JOUR
T1 - Frontotemporal dementia
T2 - Past, present, and future
AU - Ulugut, Hulya
AU - Pijnenburg, Yolande A. L.
N1 - Funding Information: We are most thankful to Professor M. Marsel Mesulam, Professor Julie Snowden, Professor David Neary, and Professor Bruce L. Miller for their invaluable contributions and generosity. Every session with them was a great lesson, inspiration, and experience. We truly appreciate them for their guidance and for sharing their personal experiences and visions. Hulya Ulugut received an Alzheimer's Association Clinician Scientist grant, and this work was supported by an Alzheimer's Association grant (AACSF‐22‐849085). Publisher Copyright: © 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
PY - 2023/11
Y1 - 2023/11
N2 - INTRODUCTION: The history of frontotemporal dementia (FTD) is both old and new. This study explores its historical roots, dating back to the 19th century, while recognizes it as a distinct neurological entity only a few decades ago. METHODS: This qualitative study and literature review provides an overview of FTD's historical background, birth, evolution, and future directions. RESULTS: Recognition of FTD was hindered by rigid perceptions of dementia, the division between neurology and psychiatry, reliance on IQ-based assessment, limited neuroimaging capabilities, and lack of pathological proof. Overcoming these barriers involved revisiting early pioneers' approaches, focusing on focal impairment, establishing non-Alzheimer's disease cohorts, fostering collaboration, and developing diagnostic criteria. Current gaps include the need for biology-oriented psychiatry education, biological biomarkers, and culturally sensitive, objective clinical instruments predicting underlying pathology. DISCUSSION: Independent multidisciplinary centers are essential. The future of FTD lies in disease-modifying therapies, presenting new opportunities for healthcare professionals and researchers.
AB - INTRODUCTION: The history of frontotemporal dementia (FTD) is both old and new. This study explores its historical roots, dating back to the 19th century, while recognizes it as a distinct neurological entity only a few decades ago. METHODS: This qualitative study and literature review provides an overview of FTD's historical background, birth, evolution, and future directions. RESULTS: Recognition of FTD was hindered by rigid perceptions of dementia, the division between neurology and psychiatry, reliance on IQ-based assessment, limited neuroimaging capabilities, and lack of pathological proof. Overcoming these barriers involved revisiting early pioneers' approaches, focusing on focal impairment, establishing non-Alzheimer's disease cohorts, fostering collaboration, and developing diagnostic criteria. Current gaps include the need for biology-oriented psychiatry education, biological biomarkers, and culturally sensitive, objective clinical instruments predicting underlying pathology. DISCUSSION: Independent multidisciplinary centers are essential. The future of FTD lies in disease-modifying therapies, presenting new opportunities for healthcare professionals and researchers.
KW - behavioral sciences
KW - dementia
KW - dementia of the frontal type
KW - frontal lobe dementia
KW - frontotemporal dementia
KW - history
KW - neuropsychiatry
KW - pick's disease and frontotemporal lobar degeneration
UR - http://www.scopus.com/inward/record.url?scp=85163383557&partnerID=8YFLogxK
U2 - https://doi.org/10.1002/alz.13363
DO - https://doi.org/10.1002/alz.13363
M3 - Review article
C2 - 37379561
SN - 1552-5260
VL - 19
SP - 5253
EP - 5263
JO - Alzheimer's and Dementia
JF - Alzheimer's and Dementia
IS - 11
ER -