Fruit and vegetable intake and type 2 diabetes: EPIC-InterAct prospective study and meta-analysis

A. J. Cooper; N. G. Forouhi; Z. Ye; B. Buijsse; L. Arriola; B. Balkau; A. Barricarte; J. W.J. Beulens; H. Boeing; F. L. Büchner; C. C. Dahm; B. De Lauzon-Guillain; G. Fagherazzi; P. W. Franks; C. Gonzalez; S. Grioni; R. Kaaks; T. J. Key; G. Masala; C. Navarro; P. Nilsson; K. Overvad; S. Panico; J. Ramón Quirós; O. Rolandsson; N. Roswall; C. Sacerdote; M. J. Sánchez; N. Slimani; I. Sluijs; A. M.W. Spijkerman; B. Teucher; A. Tjonneland; R. Tumino; S. J. Sharp; C. Langenberg; E. J.M. Feskens; E. Riboli; N. J. Wareham

doi:https://doi.org/10.1038/ejcn.2012.85

Fruit and vegetable intake and type 2 diabetes: EPIC-InterAct prospective study and meta-analysis

A. J. Cooper, N. G. Forouhi, Z. Ye, B. Buijsse, L. Arriola, B. Balkau, A. Barricarte, J. W.J. Beulens, H. Boeing, F. L. Büchner, C. C. Dahm, B. De Lauzon-Guillain, G. Fagherazzi, P. W. Franks, C. Gonzalez, S. Grioni, R. Kaaks, T. J. Key, G. Masala, C. NavarroP. Nilsson, K. Overvad, S. Panico, J. Ramón Quirós, O. Rolandsson, N. Roswall, C. Sacerdote, M. J. Sánchez, N. Slimani, I. Sluijs, A. M.W. Spijkerman, B. Teucher, A. Tjonneland, R. Tumino, S. J. Sharp, C. Langenberg, E. J.M. Feskens, E. Riboli, N. J. Wareham

Research output: Contribution to journal › Review article › Academic › peer-review

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Abstract

Fruit and vegetable intake (FVI) may reduce the risk of type 2 diabetes (T2D), but the epidemiological evidence is inconclusive. The aim of this study is to examine the prospective association of FVI with T2D and conduct an updated meta-analysis. In the European Prospective Investigation into Cancer-InterAct (EPIC-InterAct) prospective case-cohort study nested within eight European countries, a representative sample of 16 154 participants and 12 403 incident cases of T2D were identified from 340 234 individuals with 3.99 million person-years of follow-up. For the meta-analysis we identified prospective studies on FVI and T2D risk by systematic searches of MEDLINE and EMBASE until April 2011. In EPIC-InterAct, estimated FVI by dietary questionnaires varied more than twofold between countries. In adjusted analyses the hazard ratio (95% confidence interval) comparing the highest with lowest quartile of reported intake was 0.90 (0.80-1.01) for FVI; 0.89 (0.76-1.04) for fruit and 0.94 (0.84-1.05) for vegetables. Among FV subtypes, only root vegetables were inversely associated with diabetes 0.87 (0.77-0.99). In meta-analysis using pooled data from five studies including EPIC-InterAct, comparing the highest with lowest category for FVI was associated with a lower relative risk of diabetes (0.93 (0.87-1.00)). Fruit or vegetables separately were not associated with diabetes. Among FV subtypes, only green leafy vegetable (GLV) intake (relative risk: 0.84 (0.74-0.94)) was inversely associated with diabetes. Subtypes of vegetables, such as root vegetables or GLVs may be beneficial for the prevention of diabetes, while total FVI may exert a weaker overall effect.

Original language	English
Pages (from-to)	1082-1092
Number of pages	11
Journal	European Journal of Clinical Nutrition
Volume	66
Issue number	10
DOIs	https://doi.org/10.1038/ejcn.2012.85
Publication status	Published - 1 Oct 2012

Keywords

epidemiology
fruit
meta-analysis
review
type 2 diabetes mellitus
vegetables

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Cooper, A. J., Forouhi, N. G., Ye, Z., Buijsse, B., Arriola, L., Balkau, B., Barricarte, A., Beulens, J. W. J., Boeing, H., Büchner, F. L., Dahm, C. C., De Lauzon-Guillain, B., Fagherazzi, G., Franks, P. W., Gonzalez, C., Grioni, S., Kaaks, R., Key, T. J., Masala, G., ... Wareham, N. J. (2012). Fruit and vegetable intake and type 2 diabetes: EPIC-InterAct prospective study and meta-analysis. European Journal of Clinical Nutrition, 66(10), 1082-1092. https://doi.org/10.1038/ejcn.2012.85

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title = "Fruit and vegetable intake and type 2 diabetes: EPIC-InterAct prospective study and meta-analysis",

abstract = "Fruit and vegetable intake (FVI) may reduce the risk of type 2 diabetes (T2D), but the epidemiological evidence is inconclusive. The aim of this study is to examine the prospective association of FVI with T2D and conduct an updated meta-analysis. In the European Prospective Investigation into Cancer-InterAct (EPIC-InterAct) prospective case-cohort study nested within eight European countries, a representative sample of 16 154 participants and 12 403 incident cases of T2D were identified from 340 234 individuals with 3.99 million person-years of follow-up. For the meta-analysis we identified prospective studies on FVI and T2D risk by systematic searches of MEDLINE and EMBASE until April 2011. In EPIC-InterAct, estimated FVI by dietary questionnaires varied more than twofold between countries. In adjusted analyses the hazard ratio (95% confidence interval) comparing the highest with lowest quartile of reported intake was 0.90 (0.80-1.01) for FVI; 0.89 (0.76-1.04) for fruit and 0.94 (0.84-1.05) for vegetables. Among FV subtypes, only root vegetables were inversely associated with diabetes 0.87 (0.77-0.99). In meta-analysis using pooled data from five studies including EPIC-InterAct, comparing the highest with lowest category for FVI was associated with a lower relative risk of diabetes (0.93 (0.87-1.00)). Fruit or vegetables separately were not associated with diabetes. Among FV subtypes, only green leafy vegetable (GLV) intake (relative risk: 0.84 (0.74-0.94)) was inversely associated with diabetes. Subtypes of vegetables, such as root vegetables or GLVs may be beneficial for the prevention of diabetes, while total FVI may exert a weaker overall effect.",

keywords = "epidemiology, fruit, meta-analysis, review, type 2 diabetes mellitus, vegetables",

author = "Cooper, {A. J.} and Forouhi, {N. G.} and Z. Ye and B. Buijsse and L. Arriola and B. Balkau and A. Barricarte and Beulens, {J. W.J.} and H. Boeing and B{\"u}chner, {F. L.} and Dahm, {C. C.} and {De Lauzon-Guillain}, B. and G. Fagherazzi and Franks, {P. W.} and C. Gonzalez and S. Grioni and R. Kaaks and Key, {T. J.} and G. Masala and C. Navarro and P. Nilsson and K. Overvad and S. Panico and {Ram{\'o}n Quir{\'o}s}, J. and O. Rolandsson and N. Roswall and C. Sacerdote and S{\'a}nchez, {M. J.} and N. Slimani and I. Sluijs and Spijkerman, {A. M.W.} and B. Teucher and A. Tjonneland and R. Tumino and Sharp, {S. J.} and C. Langenberg and Feskens, {E. J.M.} and E. Riboli and Wareham, {N. J.}",

year = "2012",

month = oct,

day = "1",

doi = "https://doi.org/10.1038/ejcn.2012.85",

language = "English",

volume = "66",

pages = "1082--1092",

journal = "European Journal of Clinical Nutrition",

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Cooper, AJ, Forouhi, NG, Ye, Z, Buijsse, B, Arriola, L, Balkau, B, Barricarte, A, Beulens, JWJ, Boeing, H, Büchner, FL, Dahm, CC, De Lauzon-Guillain, B, Fagherazzi, G, Franks, PW, Gonzalez, C, Grioni, S, Kaaks, R, Key, TJ, Masala, G, Navarro, C, Nilsson, P, Overvad, K, Panico, S, Ramón Quirós, J, Rolandsson, O, Roswall, N, Sacerdote, C, Sánchez, MJ, Slimani, N, Sluijs, I, Spijkerman, AMW, Teucher, B, Tjonneland, A, Tumino, R, Sharp, SJ, Langenberg, C, Feskens, EJM, Riboli, E & Wareham, NJ 2012, 'Fruit and vegetable intake and type 2 diabetes: EPIC-InterAct prospective study and meta-analysis', European Journal of Clinical Nutrition, vol. 66, no. 10, pp. 1082-1092. https://doi.org/10.1038/ejcn.2012.85

TY - JOUR

T1 - Fruit and vegetable intake and type 2 diabetes

T2 - EPIC-InterAct prospective study and meta-analysis

AU - Cooper, A. J.

AU - Forouhi, N. G.

AU - Ye, Z.

AU - Buijsse, B.

AU - Arriola, L.

AU - Balkau, B.

AU - Barricarte, A.

AU - Beulens, J. W.J.

AU - Boeing, H.

AU - Büchner, F. L.

AU - Dahm, C. C.

AU - De Lauzon-Guillain, B.

AU - Fagherazzi, G.

AU - Franks, P. W.

AU - Gonzalez, C.

AU - Grioni, S.

AU - Kaaks, R.

AU - Key, T. J.

AU - Masala, G.

AU - Navarro, C.

AU - Nilsson, P.

AU - Overvad, K.

AU - Panico, S.

AU - Ramón Quirós, J.

AU - Rolandsson, O.

AU - Roswall, N.

AU - Sacerdote, C.

AU - Sánchez, M. J.

AU - Slimani, N.

AU - Sluijs, I.

AU - Spijkerman, A. M.W.

AU - Teucher, B.

AU - Tjonneland, A.

AU - Tumino, R.

AU - Sharp, S. J.

AU - Langenberg, C.

AU - Feskens, E. J.M.

AU - Riboli, E.

AU - Wareham, N. J.

PY - 2012/10/1

Y1 - 2012/10/1

N2 - Fruit and vegetable intake (FVI) may reduce the risk of type 2 diabetes (T2D), but the epidemiological evidence is inconclusive. The aim of this study is to examine the prospective association of FVI with T2D and conduct an updated meta-analysis. In the European Prospective Investigation into Cancer-InterAct (EPIC-InterAct) prospective case-cohort study nested within eight European countries, a representative sample of 16 154 participants and 12 403 incident cases of T2D were identified from 340 234 individuals with 3.99 million person-years of follow-up. For the meta-analysis we identified prospective studies on FVI and T2D risk by systematic searches of MEDLINE and EMBASE until April 2011. In EPIC-InterAct, estimated FVI by dietary questionnaires varied more than twofold between countries. In adjusted analyses the hazard ratio (95% confidence interval) comparing the highest with lowest quartile of reported intake was 0.90 (0.80-1.01) for FVI; 0.89 (0.76-1.04) for fruit and 0.94 (0.84-1.05) for vegetables. Among FV subtypes, only root vegetables were inversely associated with diabetes 0.87 (0.77-0.99). In meta-analysis using pooled data from five studies including EPIC-InterAct, comparing the highest with lowest category for FVI was associated with a lower relative risk of diabetes (0.93 (0.87-1.00)). Fruit or vegetables separately were not associated with diabetes. Among FV subtypes, only green leafy vegetable (GLV) intake (relative risk: 0.84 (0.74-0.94)) was inversely associated with diabetes. Subtypes of vegetables, such as root vegetables or GLVs may be beneficial for the prevention of diabetes, while total FVI may exert a weaker overall effect.

AB - Fruit and vegetable intake (FVI) may reduce the risk of type 2 diabetes (T2D), but the epidemiological evidence is inconclusive. The aim of this study is to examine the prospective association of FVI with T2D and conduct an updated meta-analysis. In the European Prospective Investigation into Cancer-InterAct (EPIC-InterAct) prospective case-cohort study nested within eight European countries, a representative sample of 16 154 participants and 12 403 incident cases of T2D were identified from 340 234 individuals with 3.99 million person-years of follow-up. For the meta-analysis we identified prospective studies on FVI and T2D risk by systematic searches of MEDLINE and EMBASE until April 2011. In EPIC-InterAct, estimated FVI by dietary questionnaires varied more than twofold between countries. In adjusted analyses the hazard ratio (95% confidence interval) comparing the highest with lowest quartile of reported intake was 0.90 (0.80-1.01) for FVI; 0.89 (0.76-1.04) for fruit and 0.94 (0.84-1.05) for vegetables. Among FV subtypes, only root vegetables were inversely associated with diabetes 0.87 (0.77-0.99). In meta-analysis using pooled data from five studies including EPIC-InterAct, comparing the highest with lowest category for FVI was associated with a lower relative risk of diabetes (0.93 (0.87-1.00)). Fruit or vegetables separately were not associated with diabetes. Among FV subtypes, only green leafy vegetable (GLV) intake (relative risk: 0.84 (0.74-0.94)) was inversely associated with diabetes. Subtypes of vegetables, such as root vegetables or GLVs may be beneficial for the prevention of diabetes, while total FVI may exert a weaker overall effect.

KW - epidemiology

KW - fruit

KW - meta-analysis

KW - review

KW - type 2 diabetes mellitus

KW - vegetables

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U2 - https://doi.org/10.1038/ejcn.2012.85

DO - https://doi.org/10.1038/ejcn.2012.85

M3 - Review article

C2 - 22854878

SN - 0954-3007

VL - 66

SP - 1082

EP - 1092

JO - European Journal of Clinical Nutrition

JF - European Journal of Clinical Nutrition

IS - 10

ER -

Fruit and vegetable intake and type 2 diabetes: EPIC-InterAct prospective study and meta-analysis

Abstract

Keywords

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