TY - JOUR
T1 - Functional comparison between BuMA Supreme biodegradable polymer sirolimus-eluting and durable polymer zotarolimus-eluting coronary stents using Quantitative Flow Ratio: PIONEER QFR substudy
AU - Asano, Taku
AU - Katagiri, Yuki
AU - Collet, Carlos
AU - Tenekecioglu, Erhan
AU - Miyazaki, Yosuke
AU - Sotomi, Yohei
AU - Amoroso, Giovanni
AU - Aminian, Adel
AU - Brugaletta, Salvatore
AU - Vrolix, Mathias
AU - Hernandez-Antolín, Rosana
AU - van de Harst, Pim
AU - Iñiguez, Andres
AU - Janssens, Luc
AU - Smits, Pieter
AU - Wykrzykowska, Joanna J.
AU - Ribeiro, Vasco Gama
AU - Periera, Helder
AU - da Silva, Pedro Canas
AU - Piek, Jan J.
AU - Reiber, Johan H. C.
AU - von Birgelen, Clemens
AU - Sabaté, Manel
AU - Onuma, Yoshinobu
AU - Serruys, Patrick W.
PY - 2018
Y1 - 2018
N2 - Quantitative Flow Ratio (QFR) based on 3-dimensional quantitative coronary angiography (3D-QCA) is a novel method to assess the physiological functionality after treatment with stents. The current study aimed to evaluate the difference in physiological functionality 9 months after implantation of a bioresorbable polymer-based sirolimus-eluting stent with an electrografting base layer (BuMA Supreme: B-SES) versus a durable polymer-based zotarolimus-eluting stent (Resolute: R-ZES). The current post-hoc analysis was performed in the PIONEER randomized trial (1:1 randomization to B-SES [83 patients/95 lesions] and R-ZES [87 patients/101 lesions]). QFR was measured in stented vessels in both arms at pre-procedural, post-procedural and 9-month angiography without pharmacologically induced hyperemia (contrast QFR). At 9 months, both the values of QFR distal to the stent (B-SES: 0.89±0.10 vs. 0.89±0.11, p=0.97) and the numbers of the vessels with QFR ≤0.8 were not significantly different between the two groups (11.0% vs. 12.8%, p=0.72), while the in-stent binary restenosis rate was also comparable (3.7% versus 3.5%, P=1.00). QFR gradient across the device (∆QFR) at 9 months was also similar between both groups (B-SES: 0.03±0.04 vs. 0.03±0.07, p=0.95). Quantitative flow assessment 9 months after stenting did not differ between B-SES and R-ZES, despite of a significant difference in in-stent late lumen loss
AB - Quantitative Flow Ratio (QFR) based on 3-dimensional quantitative coronary angiography (3D-QCA) is a novel method to assess the physiological functionality after treatment with stents. The current study aimed to evaluate the difference in physiological functionality 9 months after implantation of a bioresorbable polymer-based sirolimus-eluting stent with an electrografting base layer (BuMA Supreme: B-SES) versus a durable polymer-based zotarolimus-eluting stent (Resolute: R-ZES). The current post-hoc analysis was performed in the PIONEER randomized trial (1:1 randomization to B-SES [83 patients/95 lesions] and R-ZES [87 patients/101 lesions]). QFR was measured in stented vessels in both arms at pre-procedural, post-procedural and 9-month angiography without pharmacologically induced hyperemia (contrast QFR). At 9 months, both the values of QFR distal to the stent (B-SES: 0.89±0.10 vs. 0.89±0.11, p=0.97) and the numbers of the vessels with QFR ≤0.8 were not significantly different between the two groups (11.0% vs. 12.8%, p=0.72), while the in-stent binary restenosis rate was also comparable (3.7% versus 3.5%, P=1.00). QFR gradient across the device (∆QFR) at 9 months was also similar between both groups (B-SES: 0.03±0.04 vs. 0.03±0.07, p=0.95). Quantitative flow assessment 9 months after stenting did not differ between B-SES and R-ZES, despite of a significant difference in in-stent late lumen loss
U2 - https://doi.org/10.4244/EIJ-D-17-00461
DO - https://doi.org/10.4244/EIJ-D-17-00461
M3 - Article
C2 - 28994655
SN - 1774-024X
VL - 14
SP - e570-e579
JO - Eurointervention
JF - Eurointervention
IS - 5
ER -