TY - JOUR
T1 - Functional MRI correlates of emotion regulation in major depressive disorder related to depressive disease load measured over nine years
AU - van Kleef, Rozemarijn S.
AU - Müller, Amke
AU - van Velzen, Laura S.
AU - Marie Bas-Hoogendam, Janna
AU - van der Wee, Nic J. A.
AU - Schmaal, Lianne
AU - Veltman, Dick J.
AU - Rive, Maria M.
AU - Ruhé, Henricus G.
AU - Marsman, Jan-Bernard C.
AU - van Tol, Marie-José
N1 - Funding Information: The infrastructure for the NESDA study ( https://www.nesda.nl ) is funded through the Geestkracht program of the Netherlands Organization for Health Research and Development (Zon- Mw, grant no. 10-000-1002 ). This study is supported by the participating universities and mental health-care organizations: VU University Medical Center Amsterdam, University Medical Center Groningen, Leiden University Medical Center, GGZ inGeest, Arkin, GGZ Rivierduinen, Lentis, GGZ Friesland, GGZ Drenthe, Scientific Institute for Quality of Healthcare (IQ healthcare), Netherlands Institute for Health Services Research (NIVEL) and Netherlands Institute of Mental Health and Addiction (Trimbos Institute). Publisher Copyright: © 2023 The Author(s)
PY - 2023/1/1
Y1 - 2023/1/1
N2 - Major Depressive Disorder (MDD) often is a recurrent and chronic disorder. We investigated the neurocognitive underpinnings of the incremental risk for poor disease course by exploring relations between enduring depression and brain functioning during regulation of negative and positive emotions using cognitive reappraisal. We used fMRI-data from the longitudinal Netherlands Study of Depression and Anxiety acquired during an emotion regulation task in 77 individuals with MDD. Task-related brain activity was related to disease load, calculated from presence and severity of depression in the preceding nine years. Additionally, we explored task related brain-connectivity. Brain functioning in individuals with MDD was further compared to 35 controls to explore overlap between load-effects and general effects related to MDD history/presence. Disease load was not associated with changes in affect or with brain activity, but with connectivity between areas essential for processing, integrating and regulating emotional information during downregulation of negative emotions. Results did not overlap with general MDD-effects. Instead, MDD was generally associated with lower parietal activity during downregulation of negative emotions. During upregulation of positive emotions, disease load was related to connectivity between limbic regions (although driven by symptomatic state), and connectivity between frontal, insular and thalamic regions was lower in MDD (vs controls). Results suggest that previous depressive load relates to brain connectivity in relevant networks during downregulation of negative emotions. These abnormalities do not overlap with disease-general abnormalities and could foster an incremental vulnerability to recurrence or chronicity of MDD. Therefore, optimizing emotion regulation is a promising therapeutic target for improving long-term MDD course.
AB - Major Depressive Disorder (MDD) often is a recurrent and chronic disorder. We investigated the neurocognitive underpinnings of the incremental risk for poor disease course by exploring relations between enduring depression and brain functioning during regulation of negative and positive emotions using cognitive reappraisal. We used fMRI-data from the longitudinal Netherlands Study of Depression and Anxiety acquired during an emotion regulation task in 77 individuals with MDD. Task-related brain activity was related to disease load, calculated from presence and severity of depression in the preceding nine years. Additionally, we explored task related brain-connectivity. Brain functioning in individuals with MDD was further compared to 35 controls to explore overlap between load-effects and general effects related to MDD history/presence. Disease load was not associated with changes in affect or with brain activity, but with connectivity between areas essential for processing, integrating and regulating emotional information during downregulation of negative emotions. Results did not overlap with general MDD-effects. Instead, MDD was generally associated with lower parietal activity during downregulation of negative emotions. During upregulation of positive emotions, disease load was related to connectivity between limbic regions (although driven by symptomatic state), and connectivity between frontal, insular and thalamic regions was lower in MDD (vs controls). Results suggest that previous depressive load relates to brain connectivity in relevant networks during downregulation of negative emotions. These abnormalities do not overlap with disease-general abnormalities and could foster an incremental vulnerability to recurrence or chronicity of MDD. Therefore, optimizing emotion regulation is a promising therapeutic target for improving long-term MDD course.
KW - Brain activity
KW - Depression
KW - Disease load
KW - Emotion regulation
KW - Functional connectivity
UR - http://www.scopus.com/inward/record.url?scp=85177559734&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.nicl.2023.103535
DO - https://doi.org/10.1016/j.nicl.2023.103535
M3 - Article
C2 - 37984226
SN - 2213-1582
VL - 40
JO - NeuroImage: Clinical
JF - NeuroImage: Clinical
M1 - 103535
ER -