TY - JOUR
T1 - Functions and biosynthesis of plasmalogens in health and disease
AU - Brites, P.
AU - Waterham, H. R.
AU - Wanders, R. J. A.
PY - 2004
Y1 - 2004
N2 - Plasmalogens (1-O-alk-1'-enyl-2-acyl glycerophospholipids) constitute a special class of phospholipids characterized by the presence of a vinyl-ether bond at the sn-1 position. Although long considered as biological peculiarities, interest in this group of phospholipids has grown in recent years, thanks to the realization that plasmalogens are involved in different human diseases. In this review, we summarize the current state of knowledge with respect to the enzymatic synthesis of plasmalogens, the characteristic topology of the enzymes involved and the biological roles that have been assigned to plasmalogens. (C) 2004 Elsevier B.V All rights reserved
AB - Plasmalogens (1-O-alk-1'-enyl-2-acyl glycerophospholipids) constitute a special class of phospholipids characterized by the presence of a vinyl-ether bond at the sn-1 position. Although long considered as biological peculiarities, interest in this group of phospholipids has grown in recent years, thanks to the realization that plasmalogens are involved in different human diseases. In this review, we summarize the current state of knowledge with respect to the enzymatic synthesis of plasmalogens, the characteristic topology of the enzymes involved and the biological roles that have been assigned to plasmalogens. (C) 2004 Elsevier B.V All rights reserved
U2 - https://doi.org/10.1016/j.bbalip.2003.12.010
DO - https://doi.org/10.1016/j.bbalip.2003.12.010
M3 - Review article
C2 - 15164770
SN - 1388-1981
VL - 1636
SP - 219
EP - 231
JO - BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
JF - BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
IS - 2-3
ER -