TY - JOUR
T1 - Fungal mycobiome-mediated immune response
T2 - a non-negligible promoter in pancreatic oncogenesis and chemoresistance
AU - Jiang, Yaling
AU - Donati, Valentina
AU - Peters, Godefridus J.
AU - Giovannetti, Elisa
AU - Deng, Dong Mei
N1 - Funding Information: This work was supported by grants from the Cancer Center Amsterdam (CCA) Foundation, As-sociazione Italiana per la Ricerca sul Cancro (AIRC) and Fondazione Pisana per la Scienza (FPS) to Giovannetti E, and the Dutch Research Council (NWO) (OCENW.XS22.4.135) to Jiang Y. Publisher Copyright: © The Author(s) 2023.
PY - 2023
Y1 - 2023
N2 - Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers in humans due to late diagnosis and poor response to treatments. The tumor microenvironment (TME) of PDAC is characterized by a distinctive, suppressive immune profile, which inhibits the protective functions of anti-tumor immunity and thereby contributes to PDAC progression. Recently, the study of Alam et al. discovered for the first time that the intratumoral fungal mycobiome could contribute to the recruitment and activation of type 2 immune cells in the TME of PDAC via enhancing the secretion of a chemoattractant, interleukin (IL-) 33. In this article, we reviewed the important findings of this study. Together with our findings, we synthetically discussed the role of the fungal mycobiome in orchestrating the immune response and thereby modulating tumor progression.
AB - Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers in humans due to late diagnosis and poor response to treatments. The tumor microenvironment (TME) of PDAC is characterized by a distinctive, suppressive immune profile, which inhibits the protective functions of anti-tumor immunity and thereby contributes to PDAC progression. Recently, the study of Alam et al. discovered for the first time that the intratumoral fungal mycobiome could contribute to the recruitment and activation of type 2 immune cells in the TME of PDAC via enhancing the secretion of a chemoattractant, interleukin (IL-) 33. In this article, we reviewed the important findings of this study. Together with our findings, we synthetically discussed the role of the fungal mycobiome in orchestrating the immune response and thereby modulating tumor progression.
KW - Mycobiome
KW - chemoresistance
KW - interleukin 33
KW - pancreatic cancer
KW - type 2 immune cells
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U2 - https://doi.org/10.20517/cdr.2023.06
DO - https://doi.org/10.20517/cdr.2023.06
M3 - Review article
C2 - 37457135
SN - 2578-532X
VL - 6
SP - 284
EP - 290
JO - Cancer Drug Resistance
JF - Cancer Drug Resistance
IS - 2
ER -