TY - JOUR
T1 - Gait and gait-related activities and fatigue in Parkinson's disease
T2 - what is the relationship?
AU - Rochester, Lynn
AU - Jones, Diana
AU - Hetherington, Victoria
AU - Nieuwboer, Alice
AU - Willems, Anne-Marie
AU - Kwakkel, Gert
AU - van Wegen, Erwin
PY - 2006/11/30
Y1 - 2006/11/30
N2 - PURPOSE: To explore the relationship between gait and gait-related activities and fatigue in Parkinson's disease (PD).METHOD: Twenty people with idiopathic PD (12 male, 8 female; mean age 64.6 +/- 7.96) and 10 age, sex and education matched controls (6 male, 4 female; mean age 63.5 +/- 7.03) wore an activity monitor for approximately 24 h, from which the percentage time walking and standing, the number of periods of walking greater than 10 sec were derived. Prior to monitoring, levels of fatigue (Multi-dimensional Fatigue Index, MFI) were evaluated.RESULTS: Activity data related to gait were compared for the waking hours of the day, reflected by the period between 6 am and 10 pm. Overall, PD subjects demonstrated reduced activity compared to controls, however there was no significant difference between PD and controls for the percentage time spent walking (p = 0.149), standing (p = 1.0) or engaged in periods of walking that were greater than 10 sec (p = 0.059). Significantly greater levels of fatigue were experienced by PD subjects in all MFI domains compared to controls (physical p = 0.001; activity p = 0.001; general p = 0.001; mental p = 0.028; motivation p = 0.024). There was no clear association between activity and fatigue in PD subjects.CONCLUSIONS: Evidence of increased fatigue is not supported by evidence of significantly decreased levels of activity in PD subjects. The relationship between activity and fatigue therefore remains unclear, highlighting the complex nature of the relationship between these factors. Further work is required to increase our understanding of the impact of fatigue on gait and gait-related activity so that improved management can be explored.
AB - PURPOSE: To explore the relationship between gait and gait-related activities and fatigue in Parkinson's disease (PD).METHOD: Twenty people with idiopathic PD (12 male, 8 female; mean age 64.6 +/- 7.96) and 10 age, sex and education matched controls (6 male, 4 female; mean age 63.5 +/- 7.03) wore an activity monitor for approximately 24 h, from which the percentage time walking and standing, the number of periods of walking greater than 10 sec were derived. Prior to monitoring, levels of fatigue (Multi-dimensional Fatigue Index, MFI) were evaluated.RESULTS: Activity data related to gait were compared for the waking hours of the day, reflected by the period between 6 am and 10 pm. Overall, PD subjects demonstrated reduced activity compared to controls, however there was no significant difference between PD and controls for the percentage time spent walking (p = 0.149), standing (p = 1.0) or engaged in periods of walking that were greater than 10 sec (p = 0.059). Significantly greater levels of fatigue were experienced by PD subjects in all MFI domains compared to controls (physical p = 0.001; activity p = 0.001; general p = 0.001; mental p = 0.028; motivation p = 0.024). There was no clear association between activity and fatigue in PD subjects.CONCLUSIONS: Evidence of increased fatigue is not supported by evidence of significantly decreased levels of activity in PD subjects. The relationship between activity and fatigue therefore remains unclear, highlighting the complex nature of the relationship between these factors. Further work is required to increase our understanding of the impact of fatigue on gait and gait-related activity so that improved management can be explored.
KW - Activity monitoring
KW - Fatigue
KW - Female
KW - Gait
KW - Gait and gait-related activity
KW - Humans
KW - Journal Article
KW - Male
KW - Middle Aged
KW - Monitoring, Physiologic
KW - Parkinson Disease
KW - Parkinson's disease
KW - Research Support, Non-U.S. Gov't
KW - Walking
UR - http://www.scopus.com/inward/record.url?scp=33750485327&partnerID=8YFLogxK
U2 - https://doi.org/10.1080/09638280600638034
DO - https://doi.org/10.1080/09638280600638034
M3 - Article
C2 - 17071567
SN - 0963-8288
VL - 28
SP - 1365
EP - 1371
JO - Disability and rehabilitation
JF - Disability and rehabilitation
IS - 22
ER -