Ganglioside-specific IgG and IgA recruit leukocyte effector functions in Guillain-Barré syndrome

Nina M. van Sorge; Nobuhiro Yuki; Michiaki Koga; Keiichiro Susuki; Marc D. Jansen; Cees van Kooten; John H. J. Wokke; Jan G. J. van de Winkel; W. Ludo van der Pol; Leonard H. van den Berg

doi:https://doi.org/10.1016/j.jneuroim.2006.10.015

Ganglioside-specific IgG and IgA recruit leukocyte effector functions in Guillain-Barré syndrome

Nina M. van Sorge, Nobuhiro Yuki, Michiaki Koga, Keiichiro Susuki, Marc D. Jansen, Cees van Kooten, John H. J. Wokke, Jan G. J. van de Winkel, W. Ludo van der Pol, Leonard H. van den Berg

Research output: Contribution to journal › Article › Academic › peer-review

5 Citations (Scopus)

Abstract

The capacity of ganglioside-specific autoantibodies to recruit leukocyte effector functions was studied. Serum samples from 87 patients with Guillain-Barré (GBS) or Miller Fisher syndrome (MFS), containing GM1-, GQ1b-, or GD1b-specific IgG or IgA, were tested for leukocyte activating capacity. Ganglioside-specific IgG antibodies generally induced leukocyte activation, irrespective of specificity. The magnitude of leukocyte degranulation correlated with GM1- and GQ1b-specific IgG titers, but not with disease severity. Finally, GM1-specific IgA activated leukocytes through the IgA receptor, FcαRI (CD89). Therefore, both ganglioside-specific IgG and IgA can recruit leukocyte effector functions, which may be relevant in the pathogenesis of GBS and MFS. © 2006 Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	177-184
Journal	Journal of Neuroimmunology
Volume	182
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2006.10.015
Publication status	Published - Jan 2007
Externally published	Yes

Access to Document

https://doi.org/10.1016/j.jneuroim.2006.10.015

Cite this

@article{e8a89df68ac4401eb6d58b7b203a350b,

title = "Ganglioside-specific IgG and IgA recruit leukocyte effector functions in Guillain-Barr{\'e} syndrome",

abstract = "The capacity of ganglioside-specific autoantibodies to recruit leukocyte effector functions was studied. Serum samples from 87 patients with Guillain-Barr{\'e} (GBS) or Miller Fisher syndrome (MFS), containing GM1-, GQ1b-, or GD1b-specific IgG or IgA, were tested for leukocyte activating capacity. Ganglioside-specific IgG antibodies generally induced leukocyte activation, irrespective of specificity. The magnitude of leukocyte degranulation correlated with GM1- and GQ1b-specific IgG titers, but not with disease severity. Finally, GM1-specific IgA activated leukocytes through the IgA receptor, FcαRI (CD89). Therefore, both ganglioside-specific IgG and IgA can recruit leukocyte effector functions, which may be relevant in the pathogenesis of GBS and MFS. {\textcopyright} 2006 Elsevier B.V. All rights reserved.",

author = "{van Sorge}, {Nina M.} and Nobuhiro Yuki and Michiaki Koga and Keiichiro Susuki and Jansen, {Marc D.} and {van Kooten}, Cees and Wokke, {John H. J.} and {van de Winkel}, {Jan G. J.} and {van der Pol}, {W. Ludo} and {van den Berg}, {Leonard H.}",

year = "2007",

month = jan,

doi = "https://doi.org/10.1016/j.jneuroim.2006.10.015",

language = "English",

volume = "182",

pages = "177--184",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

publisher = "Elsevier",

number = "1-2",

}

TY - JOUR

T1 - Ganglioside-specific IgG and IgA recruit leukocyte effector functions in Guillain-Barré syndrome

AU - van Sorge, Nina M.

AU - Yuki, Nobuhiro

AU - Koga, Michiaki

AU - Susuki, Keiichiro

AU - Jansen, Marc D.

AU - van Kooten, Cees

AU - Wokke, John H. J.

AU - van de Winkel, Jan G. J.

AU - van der Pol, W. Ludo

AU - van den Berg, Leonard H.

PY - 2007/1

Y1 - 2007/1

N2 - The capacity of ganglioside-specific autoantibodies to recruit leukocyte effector functions was studied. Serum samples from 87 patients with Guillain-Barré (GBS) or Miller Fisher syndrome (MFS), containing GM1-, GQ1b-, or GD1b-specific IgG or IgA, were tested for leukocyte activating capacity. Ganglioside-specific IgG antibodies generally induced leukocyte activation, irrespective of specificity. The magnitude of leukocyte degranulation correlated with GM1- and GQ1b-specific IgG titers, but not with disease severity. Finally, GM1-specific IgA activated leukocytes through the IgA receptor, FcαRI (CD89). Therefore, both ganglioside-specific IgG and IgA can recruit leukocyte effector functions, which may be relevant in the pathogenesis of GBS and MFS. © 2006 Elsevier B.V. All rights reserved.

AB - The capacity of ganglioside-specific autoantibodies to recruit leukocyte effector functions was studied. Serum samples from 87 patients with Guillain-Barré (GBS) or Miller Fisher syndrome (MFS), containing GM1-, GQ1b-, or GD1b-specific IgG or IgA, were tested for leukocyte activating capacity. Ganglioside-specific IgG antibodies generally induced leukocyte activation, irrespective of specificity. The magnitude of leukocyte degranulation correlated with GM1- and GQ1b-specific IgG titers, but not with disease severity. Finally, GM1-specific IgA activated leukocytes through the IgA receptor, FcαRI (CD89). Therefore, both ganglioside-specific IgG and IgA can recruit leukocyte effector functions, which may be relevant in the pathogenesis of GBS and MFS. © 2006 Elsevier B.V. All rights reserved.

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33845923931&origin=inward

UR - https://www.ncbi.nlm.nih.gov/pubmed/17156858

U2 - https://doi.org/10.1016/j.jneuroim.2006.10.015

DO - https://doi.org/10.1016/j.jneuroim.2006.10.015

M3 - Article

C2 - 17156858

SN - 0165-5728

VL - 182

SP - 177

EP - 184

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

Ganglioside-specific IgG and IgA recruit leukocyte effector functions in Guillain-Barré syndrome

Abstract

Access to Document

Other files and links

Cite this