Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes

Marc Tjwa; Lola Bellido-Martin; Yuan Lin; Esther Lutgens; Stéphane Plaisance; Françoise Bono; Nathalie Delesque-Touchard; Caroline Hervé; Rute Moura; An D. Billiau; Cristina Aparicio; Marcel Levi; Mat Daemen; Mieke Dewerchin; Florea Lupu; Jef Arnout; Jean-Marc Herbert; Mark Waer; Pablo García de Frutos; Björn Dahlbäck; Peter Carmeliet; Marc F. Hoylaerts; Lieve Moons

doi:https://doi.org/10.1182/blood-2007-05-089565

Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes

Marc Tjwa, Lola Bellido-Martin, Yuan Lin, Esther Lutgens, Stéphane Plaisance, Françoise Bono, Nathalie Delesque-Touchard, Caroline Hervé, Rute Moura, An D. Billiau, Cristina Aparicio, Marcel Levi, Mat Daemen, Mieke Dewerchin, Florea Lupu, Jef Arnout, Jean-Marc Herbert, Mark Waer, Pablo García de Frutos, Björn DahlbäckPeter Carmeliet, Marc F. Hoylaerts, Lieve Moons

Research output: Contribution to journal › Article › Academic › peer-review

138 Citations (Scopus)

Abstract

The role of Gas6 in endothelial cell (EC) function remains incompletely characterized. Here we report that Gas6 amplifies EC activation in response to inflammatory stimuli in vitro. In vivo, Gas6 promotes and accelerates the sequestration of circulating platelets and leukocytes on activated endothelium as well as the formation and endothelial sequestration of circulating platelet-leukocyte conjugates. In addition, Gas6 promotes leukocyte extravasation, inflammation, and thrombosis in mouse models of inflammation (endotoxinemia, vasculitis, heart transplantation). Thus, Gas6 amplifies EC activation, thereby playing a key role in enhancing the interactions between ECs, platelets, and leukocytes during inflammation

Original language	English
Pages (from-to)	4096-4105
Journal	Blood
Volume	111
Issue number	8
DOIs	https://doi.org/10.1182/blood-2007-05-089565
Publication status	Published - 2008

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https://doi.org/10.1182/blood-2007-05-089565

Cite this

Tjwa, M., Bellido-Martin, L., Lin, Y., Lutgens, E., Plaisance, S., Bono, F., Delesque-Touchard, N., Hervé, C., Moura, R., Billiau, A. D., Aparicio, C., Levi, M., Daemen, M., Dewerchin, M., Lupu, F., Arnout, J., Herbert, J.-M., Waer, M., García de Frutos, P., ... Moons, L. (2008). Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes. Blood, 111(8), 4096-4105. https://doi.org/10.1182/blood-2007-05-089565

@article{3810ef689f6a411082a52cd5c99feb16,

title = "Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes",

abstract = "The role of Gas6 in endothelial cell (EC) function remains incompletely characterized. Here we report that Gas6 amplifies EC activation in response to inflammatory stimuli in vitro. In vivo, Gas6 promotes and accelerates the sequestration of circulating platelets and leukocytes on activated endothelium as well as the formation and endothelial sequestration of circulating platelet-leukocyte conjugates. In addition, Gas6 promotes leukocyte extravasation, inflammation, and thrombosis in mouse models of inflammation (endotoxinemia, vasculitis, heart transplantation). Thus, Gas6 amplifies EC activation, thereby playing a key role in enhancing the interactions between ECs, platelets, and leukocytes during inflammation",

author = "Marc Tjwa and Lola Bellido-Martin and Yuan Lin and Esther Lutgens and St{\'e}phane Plaisance and Fran{\c c}oise Bono and Nathalie Delesque-Touchard and Caroline Herv{\'e} and Rute Moura and Billiau, {An D.} and Cristina Aparicio and Marcel Levi and Mat Daemen and Mieke Dewerchin and Florea Lupu and Jef Arnout and Jean-Marc Herbert and Mark Waer and {Garc{\'i}a de Frutos}, Pablo and Bj{\"o}rn Dahlb{\"a}ck and Peter Carmeliet and Hoylaerts, {Marc F.} and Lieve Moons",

year = "2008",

doi = "https://doi.org/10.1182/blood-2007-05-089565",

language = "English",

volume = "111",

pages = "4096--4105",

journal = "Blood",

issn = "0006-4971",

publisher = "American Society of Hematology",

number = "8",

}

Tjwa, M, Bellido-Martin, L, Lin, Y, Lutgens, E, Plaisance, S, Bono, F, Delesque-Touchard, N, Hervé, C, Moura, R, Billiau, AD, Aparicio, C, Levi, M , Daemen, M, Dewerchin, M, Lupu, F, Arnout, J, Herbert, J-M, Waer, M, García de Frutos, P, Dahlbäck, B, Carmeliet, P, Hoylaerts, MF & Moons, L 2008, 'Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes', Blood, vol. 111, no. 8, pp. 4096-4105. https://doi.org/10.1182/blood-2007-05-089565

TY - JOUR

T1 - Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes

AU - Tjwa, Marc

AU - Bellido-Martin, Lola

AU - Lin, Yuan

AU - Lutgens, Esther

AU - Plaisance, Stéphane

AU - Bono, Françoise

AU - Delesque-Touchard, Nathalie

AU - Hervé, Caroline

AU - Moura, Rute

AU - Billiau, An D.

AU - Aparicio, Cristina

AU - Levi, Marcel

AU - Daemen, Mat

AU - Dewerchin, Mieke

AU - Lupu, Florea

AU - Arnout, Jef

AU - Herbert, Jean-Marc

AU - Waer, Mark

AU - García de Frutos, Pablo

AU - Dahlbäck, Björn

AU - Carmeliet, Peter

AU - Hoylaerts, Marc F.

AU - Moons, Lieve

PY - 2008

Y1 - 2008

N2 - The role of Gas6 in endothelial cell (EC) function remains incompletely characterized. Here we report that Gas6 amplifies EC activation in response to inflammatory stimuli in vitro. In vivo, Gas6 promotes and accelerates the sequestration of circulating platelets and leukocytes on activated endothelium as well as the formation and endothelial sequestration of circulating platelet-leukocyte conjugates. In addition, Gas6 promotes leukocyte extravasation, inflammation, and thrombosis in mouse models of inflammation (endotoxinemia, vasculitis, heart transplantation). Thus, Gas6 amplifies EC activation, thereby playing a key role in enhancing the interactions between ECs, platelets, and leukocytes during inflammation

AB - The role of Gas6 in endothelial cell (EC) function remains incompletely characterized. Here we report that Gas6 amplifies EC activation in response to inflammatory stimuli in vitro. In vivo, Gas6 promotes and accelerates the sequestration of circulating platelets and leukocytes on activated endothelium as well as the formation and endothelial sequestration of circulating platelet-leukocyte conjugates. In addition, Gas6 promotes leukocyte extravasation, inflammation, and thrombosis in mouse models of inflammation (endotoxinemia, vasculitis, heart transplantation). Thus, Gas6 amplifies EC activation, thereby playing a key role in enhancing the interactions between ECs, platelets, and leukocytes during inflammation

U2 - https://doi.org/10.1182/blood-2007-05-089565

DO - https://doi.org/10.1182/blood-2007-05-089565

M3 - Article

C2 - 18156494

SN - 0006-4971

VL - 111

SP - 4096

EP - 4105

JO - Blood

JF - Blood

IS - 8

ER -