TY - JOUR
T1 - Gender variation in central serous chorioretinopathy
AU - Hanumunthadu, Daren
AU - van Dijk, Elon H. C.
AU - Gangakhedkar, Sankeert
AU - Goud, Abhilash
AU - Cheung, Chui Ming Gemmy
AU - Cherfan, Daniel
AU - Sarvaiya, Chintan
AU - Banker, Alay
AU - Meyerle, Catherine
AU - Boon, Camiel J.
AU - Singh, Rishi
AU - Wu, Lihteh
AU - Chhablani, Jay
PY - 2018
Y1 - 2018
N2 - Background: Comparison of presentation and outcomes of central serous chorioretinopathy (CSC) between male and female subjects in different ethnic populations. Methods: Retrospective comparison between male and female subjects with CSC was completed. Demographic details, clinical presentations, imaging features and treatment outcomes were compared at baseline and at last follow-up. Results: This study included 155 male and 155 female subjects with a mean (CSD) age of 43.8 ± 10.3 and 57.0 ± 12.1 years, respectively, and a mean duration of follow-up of 8.49 ± 12.6 months. At presentation, there was no difference in visual acuity; however, visual acuity was significantly higher for female subjects at last follow-up (p = 0.02). Optical coherence tomography (OCT) analysis showed that subretinal deposits (p < 0.001), hyperreflective foci (p = 0.001), retinal pigment epithelial detachment (p = 0.01) and retinal pigment epithelium (RPE) irregularities (p = 0.03) were higher in male subjects at presentation. Angiographic analysis showed that diffuse leakage and RPE tracts were common in males (p = 0.01 and p = 0.02). No significant differences in choroidal dilatation or diffuse choroidal leakages were noted. Conclusions: Female subjects with CSC appear to have better outcomes, with less chances of diffuse RPE damage and other OCT features compared to males.
AB - Background: Comparison of presentation and outcomes of central serous chorioretinopathy (CSC) between male and female subjects in different ethnic populations. Methods: Retrospective comparison between male and female subjects with CSC was completed. Demographic details, clinical presentations, imaging features and treatment outcomes were compared at baseline and at last follow-up. Results: This study included 155 male and 155 female subjects with a mean (CSD) age of 43.8 ± 10.3 and 57.0 ± 12.1 years, respectively, and a mean duration of follow-up of 8.49 ± 12.6 months. At presentation, there was no difference in visual acuity; however, visual acuity was significantly higher for female subjects at last follow-up (p = 0.02). Optical coherence tomography (OCT) analysis showed that subretinal deposits (p < 0.001), hyperreflective foci (p = 0.001), retinal pigment epithelial detachment (p = 0.01) and retinal pigment epithelium (RPE) irregularities (p = 0.03) were higher in male subjects at presentation. Angiographic analysis showed that diffuse leakage and RPE tracts were common in males (p = 0.01 and p = 0.02). No significant differences in choroidal dilatation or diffuse choroidal leakages were noted. Conclusions: Female subjects with CSC appear to have better outcomes, with less chances of diffuse RPE damage and other OCT features compared to males.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85049634000&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/29988073
U2 - https://doi.org/10.1038/s41433-018-0163-7
DO - https://doi.org/10.1038/s41433-018-0163-7
M3 - Article
C2 - 29988073
SN - 0950-222X
VL - 32
SP - 1703
EP - 1709
JO - Eye (London, England)
JF - Eye (London, England)
IS - 11
ER -