TY - JOUR
T1 - Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits
AU - the Million Veteran Program
AU - Evangelou, Evangelos
AU - Warren, Helen R.
AU - Mosen-Ansorena, David
AU - Mifsud, Borbala
AU - Pazoki, Raha
AU - Gao, He
AU - Ntritsos, Georgios
AU - Dimou, Niki
AU - Cabrera, Claudia P.
AU - Karaman, Ibrahim
AU - Ng, Fu Liang
AU - Evangelou, Marina
AU - Witkowska, Katarzyna
AU - Tzanis, Evan
AU - Hellwege, Jacklyn N.
AU - Giri, Ayush
AU - Velez Edwards, Digna R.
AU - Sun, Yan V.
AU - Cho, Kelly
AU - Gaziano, J. Michael
AU - Wilson, Peter W.F.
AU - Tsao, Philip S.
AU - Kovesdy, Csaba P.
AU - Esko, Tonu
AU - Mägi, Reedik
AU - Milani, Lili
AU - Almgren, Peter
AU - Boutin, Thibaud
AU - Debette, Stéphanie
AU - Ding, Jun
AU - Giulianini, Franco
AU - Holliday, Elizabeth G.
AU - Jackson, Anne U.
AU - Li-Gao, Ruifang
AU - Lin, Wei Yu
AU - Luan, Jian’an
AU - Mangino, Massimo
AU - Oldmeadow, Christopher
AU - Prins, Bram Peter
AU - Qian, Yong
AU - Sargurupremraj, Muralidharan
AU - Shah, Nabi
AU - Surendran, Praveen
AU - Thériault, Sébastien
AU - Verweij, Niek
AU - Willems, Sara M.
AU - Boomsma, Dorret I.
AU - de Geus, Eco J.C.
AU - Hottenga, Jouke Jan
AU - Willemsen, Gonneke
AU - Zhao, Jing-Hua
AU - Jansen, Rick
AU - Milaneschi, Yuri
AU - Penninx, Brenda W. J. H.
PY - 2018/10
Y1 - 2018/10
N2 - High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.
AB - High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.
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UR - https://www.ncbi.nlm.nih.gov/pubmed/30224653
U2 - https://doi.org/10.1038/s41588-018-0205-x
DO - https://doi.org/10.1038/s41588-018-0205-x
M3 - Article
C2 - 30224653
SN - 1061-4036
VL - 50
SP - 1412
EP - 1431
JO - Nature Genetics
JF - Nature Genetics
IS - 10
ER -
