Genetic determinants of response to statins

Bas J. M. Peters; Olaf H. Klungel; Anthonius de Boer; Anke-Hilse Maitland-van der Zee

doi:https://doi.org/10.1586/erc.09.83

Genetic determinants of response to statins

Bas J. M. Peters, Olaf H. Klungel, Anthonius de Boer, Anke-Hilse Maitland-van der Zee

Research output: Contribution to journal › Article › Academic › peer-review

18 Citations (Scopus)

Abstract

In developed countries, cardiovascular disease is one of the leading causes of death. Statins are abundantly prescribed to reduce the risk of coronary artery disease by lowering cholesterol. Genetic factors are thought to be partly responsible for the interindividual variation in the response to statins. This article reviews the most important studies conducted on pharmacogenetics of statins. Currently, there is no evidence to advocate pharmacogenetic testing before initiating therapy

Original language	English
Pages (from-to)	977-983
Journal	Expert Review of Cardiovascular Therapy
Volume	7
Issue number	8
DOIs	https://doi.org/10.1586/erc.09.83
Publication status	Published - 2009
Externally published	Yes

Access to Document

https://doi.org/10.1586/erc.09.83

Cite this

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title = "Genetic determinants of response to statins",

abstract = "In developed countries, cardiovascular disease is one of the leading causes of death. Statins are abundantly prescribed to reduce the risk of coronary artery disease by lowering cholesterol. Genetic factors are thought to be partly responsible for the interindividual variation in the response to statins. This article reviews the most important studies conducted on pharmacogenetics of statins. Currently, there is no evidence to advocate pharmacogenetic testing before initiating therapy",

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AB - In developed countries, cardiovascular disease is one of the leading causes of death. Statins are abundantly prescribed to reduce the risk of coronary artery disease by lowering cholesterol. Genetic factors are thought to be partly responsible for the interindividual variation in the response to statins. This article reviews the most important studies conducted on pharmacogenetics of statins. Currently, there is no evidence to advocate pharmacogenetic testing before initiating therapy

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