@article{82c28bc0b93b4a81a08788a1239eba4b,
title = "Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept",
abstract = "Schizophrenia is a devastating psychiatric illness with high heritability. Brain structure and function differ, on average, between people with schizophrenia and healthy individuals. As common genetic associations are emerging for both schizophrenia and brain imaging phenotypes, we can now use genome-wide data to investigate genetic overlap. Here we integrated results from common variant studies of schizophrenia (33,636 cases, 43,008 controls) and volumes of several (mainly subcortical) brain structures (11,840 subjects). We did not find evidence of genetic overlap between schizophrenia risk and subcortical volume measures either at the level of common variant genetic architecture or for single genetic markers. These results provide a proof of concept (albeit based on a limited set of structural brain measures) and define a roadmap for future studies investigating the genetic covariance between structural or functional brain phenotypes and risk for psychiatric disorders",
author = "Barbara Franke and Stein, {Jason L.} and Stephan Ripke and Verneri Anttila and Hibar, {Derrek P.} and {van Hulzen}, {Kimm J. E.} and Alejandro Arias-Vasquez and Smoller, {Jordan W.} and Nichols, {Thomas E.} and Neale, {Michael C.} and McIntosh, {Andrew M.} and Phil Lee and McMahon, {Francis J.} and Andreas Meyer-Lindenberg and Manuel Mattheisen and Andreassen, {Ole A.} and Oliver Gruber and Sachdev, {Perminder S.} and Roberto Roiz-Santia{\~n}ez and Saykin, {Andrew J.} and Stefan Ehrlich and Mather, {Karen A.} and Turner, {Jessica A.} and Emanuel Schwarz and Anbupalam Thalamuthu and Yin Yao and Ho, {Yvonne Y. W.} and Martin, {Nicholas G.} and Wright, {Margaret J.} and O'Donovan, {Michael C.} and Thompson, {Paul M.} and Neale, {Benjamin M.} and Medland, {Sarah E.} and Sullivan, {Patrick F.} and {AUTHOR GROUP} and Aiden Corvin and Walters, {James T. R.} and Kai-How Farh and Holmans, {Peter A.} and Brendan Bulik-Sullivan and Collier, {David A.} and Hailiang Huang and Pers, {Tune H.} and Ingrid Agartz and Esben Agerbo and Margot Albus and Madeline Alexander and Farooq Amin and Bacanu, {Silviu A.} and Martin Begemann and {de Haan}, Lieuwe and {den Braber}, A. and I.O. Fedko and J.J. Hottenga and {van t Ent}, D. and D.I. Boomsma and {de Geus}, E.J.C.",
year = "2016",
doi = "https://doi.org/10.1038/nn.4228",
language = "English",
volume = "19",
pages = "420--+",
journal = "Nature neuroscience",
issn = "1097-6256",
publisher = "Nature Publishing Group",
number = "3",
}