TY - JOUR
T1 - Genetic studies of panic disorder
T2 - A review
AU - Van den Heuvel, O. A.
AU - Van de Wetering, B. J.M.
AU - Veltman, D. J.
AU - Pauls, D. L.
PY - 2000/1/1
Y1 - 2000/1/1
N2 - Background: A review of the studies examining the genetic etiology of panic disorder shows the familial nature of the disorder and demonstrates that the etiology is greatly influenced by genetic factors. Strong evidence for vertical transmission in family studies led to molecular genetic studies, of which association designs appear promising, particularly when based on trait markers. Data Sources: The MEDLINE and PsycLIT databases were searched for all reports published between 1966 and 2000 containing the keywords panic, genetic, twin, adoption, linkage, association, and QTL. Conclusion: We conclude that the multifactorial nature of panic disorder requires a multi-disciplinary approach to gain insight into the determinants of the phenotype and the interaction of environmental and genetic factors.
AB - Background: A review of the studies examining the genetic etiology of panic disorder shows the familial nature of the disorder and demonstrates that the etiology is greatly influenced by genetic factors. Strong evidence for vertical transmission in family studies led to molecular genetic studies, of which association designs appear promising, particularly when based on trait markers. Data Sources: The MEDLINE and PsycLIT databases were searched for all reports published between 1966 and 2000 containing the keywords panic, genetic, twin, adoption, linkage, association, and QTL. Conclusion: We conclude that the multifactorial nature of panic disorder requires a multi-disciplinary approach to gain insight into the determinants of the phenotype and the interaction of environmental and genetic factors.
UR - http://www.scopus.com/inward/record.url?scp=0033764573&partnerID=8YFLogxK
U2 - https://doi.org/10.4088/JCP.v61n1008
DO - https://doi.org/10.4088/JCP.v61n1008
M3 - Review article
C2 - 11078037
SN - 0160-6689
VL - 61
SP - 756
EP - 766
JO - Journal of Clinical Psychiatry
JF - Journal of Clinical Psychiatry
IS - 10
ER -