@article{f835625e1fdf46df8036599bcc96b757,
title = "Genetic variants in SLC22A17 and SLC22A7 are associated with anthracycline-induced cardiotoxicity in children",
abstract = "To identify novel variants associated with anthracycline-induced cardiotoxicity and to assess these in a genotype-guided risk prediction model. Two cohorts treated for childhood cancer (n = 344 and 218, respectively) were genotyped for 4578 SNPs in drug ADME and toxicity genes. Significant associations were identified in SLC22A17 (rs4982753; p = 0.0078) and SLC22A7 (rs4149178; p = 0.0034), with replication in the second cohort (p = 0.0071 and 0.047, respectively). Additional evidence was found for SULT2B1 and several genes related to oxidative stress. Adding the SLC22 variants to the prediction model improved its discriminative ability (AUC 0.78 vs 0.75 [p = 0.029]). Two novel variants in SLC22A17 and SLC22A7 were significantly associated with anthracycline-induced cardiotoxicity and improved a genotype-guided risk prediction model, which could improve patient risk stratification",
author = "Henk Visscher and Rassekh, {S. Rod} and Sandor, {George S.} and Caron, {Huib N.} and {van Dalen}, {Elvira C.} and Kremer, {Leontien C.} and {van der Pal}, {Helena J.} and Rogers, {Paul C.} and Rieder, {Michael J.} and Carleton, {Bruce C.} and Hayden, {Michael R.} and Ross, {Colin J.} and {AUTHOR GROUP} and Michael Hayden and Bruce Carleton and Colin Ross and Stuart MacLeod and Wyeth Wasserman and Craig Mitton and Anne Smith and Claudette Hildebrand and Pastrana, {Lucila Castro} and Reza Ghannadan and Rod Rassekh and Fudan Miao and Michelle Higginson and Adrienne Borrie and Ursula Amstutz and Amit Bhavsar and Cheri Nijssen-Jordan and David Johnson and Linda Verbeek and Rick Kaczowka and Paul Grundy and Kent Stobart and Bev Wilson and Sunil Desai and Maria Spavor and Linda Churcher and Terence Chow and Kevin Hall and Nick Honcharik and Sara Israels and Shanna Chan and Byron Garnham and Michelle Staub and Michael Rieder and Becky Malkin and Carol Portwine and Amy Cranston and Gideon Koren",
year = "2015",
doi = "https://doi.org/10.2217/PGS.15.61",
language = "English",
volume = "16",
pages = "1065--1076",
journal = "Pharmacogenomics",
issn = "1462-2416",
publisher = "Future Medicine Ltd.",
number = "10",
}