Genetic variation in IL28B and treatment outcome in HBeAg-positive and -negative chronic hepatitis B patients treated with Peg interferon alfa-2a and adefovir

A. de Niet; R. B. Takkenberg; R. Benayed; B. Riley-Gillis; C. J. Weegink; H. L. Zaaijer; M. Koot; P. L. M. Jansen; M. G. H. M. Beld; U. Lopatin; H. W. Reesink

doi:https://doi.org/10.3109/00365521.2011.648952

Genetic variation in IL28B and treatment outcome in HBeAg-positive and -negative chronic hepatitis B patients treated with Peg interferon alfa-2a and adefovir

A. de Niet, R. B. Takkenberg, R. Benayed, B. Riley-Gillis, C. J. Weegink, H. L. Zaaijer, M. Koot, P. L. M. Jansen, M. G. H. M. Beld, U. Lopatin, H. W. Reesink

Research output: Contribution to journal › Article › Academic › peer-review

29 Citations (Scopus)

Abstract

In a cohort of 95 chronic hepatitis B patients, who were treated with peg-interferon and adefovir for 1 year, and who had 15% HBsAg loss (overall), no association was found between IL28B polymorphisms and HBeAg seroconversion or HBsAg clearance. These findings suggest that any association with outcome, if present, is less than that seen in chronic hepatitis C. Additional studies are needed to enlarge sample size and to refine our understanding of IL28B biology in the context of chronic hepatitis B response to immunomodulatory and direct antiviral therapy

Original language	English
Pages (from-to)	475-481
Journal	Scandinavian journal of gastroenterology
Volume	47
Issue number	4
DOIs	https://doi.org/10.3109/00365521.2011.648952
Publication status	Published - 2012

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https://doi.org/10.3109/00365521.2011.648952

Cite this

de Niet, A., Takkenberg, R. B., Benayed, R., Riley-Gillis, B., Weegink, C. J., Zaaijer, H. L., Koot, M., Jansen, P. L. M., Beld, M. G. H. M., Lopatin, U., & Reesink, H. W. (2012). Genetic variation in IL28B and treatment outcome in HBeAg-positive and -negative chronic hepatitis B patients treated with Peg interferon alfa-2a and adefovir. Scandinavian journal of gastroenterology, 47(4), 475-481. https://doi.org/10.3109/00365521.2011.648952

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title = "Genetic variation in IL28B and treatment outcome in HBeAg-positive and -negative chronic hepatitis B patients treated with Peg interferon alfa-2a and adefovir",

abstract = "In a cohort of 95 chronic hepatitis B patients, who were treated with peg-interferon and adefovir for 1 year, and who had 15% HBsAg loss (overall), no association was found between IL28B polymorphisms and HBeAg seroconversion or HBsAg clearance. These findings suggest that any association with outcome, if present, is less than that seen in chronic hepatitis C. Additional studies are needed to enlarge sample size and to refine our understanding of IL28B biology in the context of chronic hepatitis B response to immunomodulatory and direct antiviral therapy",

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de Niet, A, Takkenberg, RB, Benayed, R, Riley-Gillis, B, Weegink, CJ, Zaaijer, HL, Koot, M, Jansen, PLM, Beld, MGHM, Lopatin, U & Reesink, HW 2012, 'Genetic variation in IL28B and treatment outcome in HBeAg-positive and -negative chronic hepatitis B patients treated with Peg interferon alfa-2a and adefovir', Scandinavian journal of gastroenterology, vol. 47, no. 4, pp. 475-481. https://doi.org/10.3109/00365521.2011.648952

Genetic variation in IL28B and treatment outcome in HBeAg-positive and -negative chronic hepatitis B patients treated with Peg interferon alfa-2a and adefovir. / de Niet, A.; Takkenberg, R. B.; Benayed, R. et al.
In: Scandinavian journal of gastroenterology, Vol. 47, No. 4, 2012, p. 475-481.

Research output: Contribution to journal › Article › Academic › peer-review

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AU - Riley-Gillis, B.

AU - Weegink, C. J.

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AU - Koot, M.

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AU - Lopatin, U.

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AB - In a cohort of 95 chronic hepatitis B patients, who were treated with peg-interferon and adefovir for 1 year, and who had 15% HBsAg loss (overall), no association was found between IL28B polymorphisms and HBeAg seroconversion or HBsAg clearance. These findings suggest that any association with outcome, if present, is less than that seen in chronic hepatitis C. Additional studies are needed to enlarge sample size and to refine our understanding of IL28B biology in the context of chronic hepatitis B response to immunomodulatory and direct antiviral therapy

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