TY - JOUR
T1 - Genetics of Obesity
AU - Kleinendorst, Lotte
AU - van Haelst, Mieke M.
AU - van den Akker, Erica L. T.
N1 - Copyright: This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Obesity is caused by an imbalance between energy intake and output, influenced by numerous environmental, biological, and genetic factors. Only a minority of people with obesity have a genetic defect that is the main cause of their obesity. A key symptom for most of these disorders is early-onset obesity and hyperphagia. For some genetic obesity disorders, the hyperphagia is the main characteristic, often caused by disruptions of the leptin-melanocortin pathway, the central pathway that regulates the body's satiety and energy balance. For other disorders, obesity is part of a distinct combination of other clinical features such as intellectual disability, dysmorphic facial features, or organ abnormalities. This chapter focuses on genetic obesity disorders and also summarizes the present knowledge on the genetics of the more common polygenic/multifactorial obesity.
AB - Obesity is caused by an imbalance between energy intake and output, influenced by numerous environmental, biological, and genetic factors. Only a minority of people with obesity have a genetic defect that is the main cause of their obesity. A key symptom for most of these disorders is early-onset obesity and hyperphagia. For some genetic obesity disorders, the hyperphagia is the main characteristic, often caused by disruptions of the leptin-melanocortin pathway, the central pathway that regulates the body's satiety and energy balance. For other disorders, obesity is part of a distinct combination of other clinical features such as intellectual disability, dysmorphic facial features, or organ abnormalities. This chapter focuses on genetic obesity disorders and also summarizes the present knowledge on the genetics of the more common polygenic/multifactorial obesity.
KW - Body weight regulation
KW - Common obesity
KW - Early-onset obesity
KW - Genetic obesity
KW - Hyperphagia
KW - Leptin-melanocortin pathway
KW - Non-syndromic obesity
KW - Syndromic obesity
UR - http://www.scopus.com/inward/record.url?scp=85072930239&partnerID=8YFLogxK
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85072930239&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/31588542
U2 - https://doi.org/10.1007/978-3-030-25905-1_19
DO - https://doi.org/10.1007/978-3-030-25905-1_19
M3 - Review article
C2 - 31588542
SN - 1664-431X
VL - 111
SP - 419
EP - 441
JO - Experientia supplementum (2012)
JF - Experientia supplementum (2012)
ER -