Abstract
- Obesity is an important risk factor for morbidity and premature death, as well as a contributing factor to psychosocial problems. The incidence of obesity has increased dramatically over the last few decades.- Obesity is considered to be a multifactorial condition in which both environmental factors and genetic factors play a part.- In approximately 5% of patients with morbid obesity, a monogenic cause can be identified. Mutations in the MC4R gene are the most frequently occurring monogenic cause of obesity.- The department of Genetics at the VU University Medical Center Amsterdam offers morbidly obese patients a diagnostic analysis of 50 obesity-associated genes. - An underlying obesity-associated genetic defect can influence patient response to certain treatments. Therefore, if the gene defect is known, it can be taken into account when considering treatment options.- The understanding of the genetics of obesity will significantly contribute to research into the development of personalized treatment options.
Translated title of the contribution | Genetic obesity: new diagnostic options |
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Original language | Dutch |
Pages (from-to) | D688 |
Journal | Nederlands Tijdschrift voor Geneeskunde |
Volume | 161 |
Publication status | Published - 2017 |
Keywords
- Genetic Predisposition to Disease
- Humans
- Mutation
- Obesity, Morbid/genetics
- Receptor, Melanocortin, Type 4/genetics
- Risk Factors