Genital and urinary tract infections in diabetes: impact of pharmacologically-induced glucosuria

Suzanne Geerlings, Vivian Fonseca, David Castro-Diaz, James List, Shamik Parikh

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171 Citations (Scopus)

Abstract

Predisposition to genital infections and urinary tract infections (UTIs) in type 2 diabetes mellitus (T2DM) results from several factors such as glucosuria, adherence of bacteria to the uroepithelium and immune dysfunction. The tendency to develop these infections could be even higher in patients with T2DM treated with the emerging class of sodium-glucose cotransporter-2 (SGLT2) inhibitors. Studies have shown that pharmacologically-induced glucosuria with SGLT2 inhibitors raises the risk of developing genital infections and, to a relatively lesser extent, UTIs. However, a definitive dose relationship of the incidence of these infections with the SGLT2 doses is not evident in the existing data. Therefore, the precise role of glucosuria as a causative factor for these infections is yet to be fully elucidated
Original languageEnglish
Pages (from-to)373-381
JournalDiabetes research and clinical practice
Volume103
Issue number3
DOIs
Publication statusPublished - 2014

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