Abstract
Original language | English |
---|---|
Pages (from-to) | 312-U120 |
Journal | Nature Genetics |
Volume | 44 |
Issue number | 3 |
DOIs | |
Publication status | Published - 2012 |
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In: Nature Genetics, Vol. 44, No. 3, 2012, p. 312-U120.
Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - Genome-wide association analysis identifies three new breast cancer susceptibility loci
AU - Ghoussaini, Maya
AU - Fletcher, Olivia
AU - Michailidou, Kyriaki
AU - Turnbull, Clare
AU - Schmidt, Marjanka K.
AU - Dicks, Ed
AU - Dennis, Joe
AU - Wang, Qin
AU - Humphreys, Manjeet K.
AU - Luccarini, Craig
AU - Baynes, Caroline
AU - Conroy, Don
AU - Maranian, Melanie
AU - Ahmed, Shahana
AU - Driver, Kristy
AU - Johnson, Nichola
AU - Orr, Nicholas
AU - dos Santos Silva, Isabel
AU - Waisfisz, Quinten
AU - Meijers-Heijboer, Hanne
AU - Uitterlinden, Andre G.
AU - Rivadeneira, Fernando
AU - Hall, Per
AU - Czene, Kamila
AU - Irwanto, Astrid
AU - Liu, Jianjun
AU - Nevanlinna, Heli
AU - Aittomäki, Kristiina
AU - Blomqvist, Carl
AU - Meindl, Alfons
AU - Schmutzler, Rita K.
AU - Müller-Myhsok, Bertram
AU - Lichtner, Peter
AU - Chang-Claude, Jenny
AU - Hein, Rebecca
AU - Nickels, Stefan
AU - Flesch-Janys, Dieter
AU - Tsimiklis, Helen
AU - Makalic, Enes
AU - Schmidt, Daniel
AU - Bui, Minh
AU - Hopper, John L.
AU - Apicella, Carmel
AU - Park, Daniel J.
AU - Southey, Melissa
AU - Hunter, David J.
AU - Chanock, Stephen J.
AU - Broeks, Annegien
AU - Verhoef, Senno
AU - Hogervorst, Frans B. L.
AU - Fasching, Peter A.
AU - Lux, Michael P.
AU - Beckmann, Matthias W.
AU - Ekici, Arif B.
AU - Sawyer, Elinor
AU - Tomlinson, Ian
AU - Kerin, Michael
AU - Marme, Frederik
AU - Schneeweiss, Andreas
AU - Sohn, Christof
AU - Burwinkel, Barbara
AU - Guénel, Pascal
AU - Truong, Thérèse
AU - Cordina-Duverger, Emilie
AU - Menegaux, Florence
AU - Bojesen, Stig E.
AU - Nordestgaard, Børge G.
AU - Nielsen, Sune F.
AU - Flyger, Henrik
AU - Milne, Roger L.
AU - Alonso, M. Rosario
AU - González-Neira, Anna
AU - Benítez, Javier
AU - Anton-Culver, Hoda
AU - Ziogas, Argyrios
AU - Bernstein, Leslie
AU - Dur, Christina Clarke
AU - Brenner, Hermann
AU - Müller, Heiko
AU - Arndt, Volker
AU - Stegmaier, Christa
AU - Justenhoven, Christina
AU - Brauch, Hiltrud
AU - Brüning, Thomas
AU - Wang-Gohrke, Shan
AU - Eilber, Ursula
AU - Dörk, Thilo
AU - Schürmann, Peter
AU - Bremer, Michael
AU - Hillemanns, Peter
AU - Bogdanova, Natalia V.
AU - Antonenkova, Natalia N.
AU - Rogov, Yuri I.
AU - Karstens, Johann H.
AU - Bermisheva, Marina
AU - Prokofieva, Darya
AU - Khusnutdinova, Elza
AU - Lindblom, Annika
AU - Margolin, Sara
AU - Mannermaa, Arto
AU - Kataja, Vesa
AU - Kosma, Veli-Matti
AU - Hartikainen, Jaana M.
AU - Lambrechts, Diether
AU - Yesilyurt, Betul T.
AU - Floris, Giuseppe
AU - Leunen, Karin
AU - Manoukian, Siranoush
AU - Bonanni, Bernardo
AU - Fortuzzi, Stefano
AU - Peterlongo, Paolo
AU - Couch, Fergus J.
AU - Wang, Xianshu
AU - Stevens, Kristen
AU - Lee, Adam
AU - Giles, Graham G.
AU - Baglietto, Laura
AU - Severi, Gianluca
AU - McLean, Catriona
AU - Alnaes, Grethe Grenaker
AU - Kristensen, Vessela
AU - Børrensen-Dale, Anne-Lise
AU - John, Esther M.
AU - Miron, Alexander
AU - Winqvist, Robert
AU - Pylkäs, Katri
AU - Jukkola-Vuorinen, Arja
AU - Kauppila, Saila
AU - Andrulis, Irene L.
AU - Glendon, Gord
AU - Mulligan, Anna Marie
AU - Devilee, Peter
AU - van Asperen, Christie J.
AU - Tollenaar, Rob A. E. M.
AU - Seynaeve, Caroline
AU - Figueroa, Jonine D.
AU - Garcia-Closas, Montserrat
AU - Brinton, Louise
AU - Lissowska, Jolanta
AU - Hooning, Maartje J.
AU - Hollestelle, Antoinette
AU - Oldenburg, Rogier A.
AU - van den Ouweland, Ans M. W.
AU - Cox, Angela
AU - Reed, Malcolm W. R.
AU - Shah, Mitul
AU - Jakubowska, Ania
AU - Lubinski, Jan
AU - Jaworska, Katarzyna
AU - Durda, Katarzyna
AU - Jones, Michael
AU - Schoemaker, Minouk
AU - Ashworth, Alan
AU - Swerdlow, Anthony
AU - Beesley, Jonathan
AU - Chen, Xiaoqing
AU - Muir, Kenneth R.
AU - Lophatananon, Artitaya
AU - Rattanamongkongul, Suthee
AU - Chaiwerawattana, Arkom
AU - Kang, Daehee
AU - Yoo, Keun-Young
AU - Noh, Dong-Young
AU - Shen, Chen-Yang
AU - Yu, Jyh-Cherng
AU - Wu, Pei-Ei
AU - Hsiung, Chia-Ni
AU - Perkins, Annie
AU - Swann, Ruth
AU - Velentzis, Louiza
AU - Eccles, Diana M.
AU - Tapper, Will J.
AU - Gerty, Susan M.
AU - Graham, Nikki J.
AU - Ponder, Bruce A. J.
AU - Chenevix-Trench, Georgia
AU - Pharoah, Paul D. P.
AU - Lathrop, Mark
AU - Dunning, Alison M.
AU - Rahman, Nazneen
AU - Peto, Julian
AU - Easton, Douglas F.
AU - Aittomaki, K.
AU - Guenal, P.
AU - Dork, T.
PY - 2012
Y1 - 2012
N2 - Breast cancer is the most common cancer among women. To date, 22 common breast cancer susceptibility loci have been identified accounting for similar to 8% of the heritability of the disease. We attempted to replicate 72 promising associations from two independent genome-wide association studies (GWAS) in similar to 70,000 cases and similar to 68,000 controls from 41 case-control studies and 9 breast cancer GWAS. We identified three new breast cancer risk loci at 12p11 (rs10771399; P = 2.7 x 10(-35)), 12q24 (rs1292011; P = 4.3 x 10(-19)) and 21q21 (rs2823093; P = 1.1 x 10(-12)). rs10771399 was associated with similar relative risks for both estrogen receptor (ER)-negative and ER-positive breast cancer, whereas the other two loci were associated only with ER-positive disease. Two of the loci lie in regions that contain strong plausible candidate genes: PTHLH (12p11) has a crucial role in mammary gland development and the establishment of bone metastasis in breast cancer, and NRIP1 (21q21) encodes an ER cofactor and has a role in the regulation of breast cancer cell growth
AB - Breast cancer is the most common cancer among women. To date, 22 common breast cancer susceptibility loci have been identified accounting for similar to 8% of the heritability of the disease. We attempted to replicate 72 promising associations from two independent genome-wide association studies (GWAS) in similar to 70,000 cases and similar to 68,000 controls from 41 case-control studies and 9 breast cancer GWAS. We identified three new breast cancer risk loci at 12p11 (rs10771399; P = 2.7 x 10(-35)), 12q24 (rs1292011; P = 4.3 x 10(-19)) and 21q21 (rs2823093; P = 1.1 x 10(-12)). rs10771399 was associated with similar relative risks for both estrogen receptor (ER)-negative and ER-positive breast cancer, whereas the other two loci were associated only with ER-positive disease. Two of the loci lie in regions that contain strong plausible candidate genes: PTHLH (12p11) has a crucial role in mammary gland development and the establishment of bone metastasis in breast cancer, and NRIP1 (21q21) encodes an ER cofactor and has a role in the regulation of breast cancer cell growth
U2 - https://doi.org/10.1038/ng.1049
DO - https://doi.org/10.1038/ng.1049
M3 - Article
C2 - 22267197
SN - 1061-4036
VL - 44
SP - 312-U120
JO - Nature Genetics
JF - Nature Genetics
IS - 3
ER -