Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci

Espen Melum; Andre Franke; Christoph Schramm; Tobias J. Weismüller; Daniel Nils Gotthardt; Felix A. Offner; Brian D. Juran; Jon K. Laerdahl; Verena Labi; Einar Björnsson; Rinse K. Weersma; Liesbet Henckaerts; Andreas Teufel; Christian Rust; Eva Ellinghaus; Tobias Balschun; Kirsten Muri Boberg; David Ellinghaus; Annika Bergquist; Peter Sauer; Euijung Ryu; Johannes Roksund Hov; Jochen Wedemeyer; Björn Lindkvist; Michael Wittig; Robert J. Porte; Kristian Holm; Christian Gieger; H.-Erich Wichmann; Pieter Stokkers; Cyriel Y. Ponsioen; Heiko Runz; Adolf Stiehl; Cisca Wijmenga; Martina Sterneck; Severine Vermeire; Ulrich Beuers; Andreas Villunger; Erik Schrumpf; Konstantinos N. Lazaridis; Michael P. Manns; Stefan Schreiber; Tom H. Karlsen

doi:https://doi.org/10.1038/ng.728

Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci

Espen Melum, Andre Franke, Christoph Schramm, Tobias J. Weismüller, Daniel Nils Gotthardt, Felix A. Offner, Brian D. Juran, Jon K. Laerdahl, Verena Labi, Einar Björnsson, Rinse K. Weersma, Liesbet Henckaerts, Andreas Teufel, Christian Rust, Eva Ellinghaus, Tobias Balschun, Kirsten Muri Boberg, David Ellinghaus, Annika Bergquist, Peter SauerEuijung Ryu, Johannes Roksund Hov, Jochen Wedemeyer, Björn Lindkvist, Michael Wittig, Robert J. Porte, Kristian Holm, Christian Gieger, H.-Erich Wichmann, Pieter Stokkers, Cyriel Y. Ponsioen, Heiko Runz, Adolf Stiehl, Cisca Wijmenga, Martina Sterneck, Severine Vermeire, Ulrich Beuers, Andreas Villunger, Erik Schrumpf, Konstantinos N. Lazaridis, Michael P. Manns, Stefan Schreiber, Tom H. Karlsen

Research output: Contribution to journal › Article › Academic › peer-review

214 Citations (Scopus)

Abstract

Primary sclerosing cholangitis (PSC) is a chronic bile duct disease affecting 2.4-7.5% of individuals with inflammatory bowel disease. We performed a genome-wide association analysis of 2,466,182 SNPs in 715 individuals with PSC and 2,962 controls, followed by replication in 1,025 PSC cases and 2,174 controls. We detected non-HLA associations at rs3197999 in MST1 and rs6720394 near BCL2L11 (combined P = 1.1 x 10(-16) and P = 4.1 x 10(-8), respectively)

Original language	English
Pages (from-to)	17-19
Journal	Nature Genetics
Volume	43
Issue number	1
DOIs	https://doi.org/10.1038/ng.728
Publication status	Published - 2011

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https://doi.org/10.1038/ng.728

Cite this

Melum, E., Franke, A., Schramm, C., Weismüller, T. J., Gotthardt, D. N., Offner, F. A., Juran, B. D., Laerdahl, J. K., Labi, V., Björnsson, E., Weersma, R. K., Henckaerts, L., Teufel, A., Rust, C., Ellinghaus, E., Balschun, T., Boberg, K. M., Ellinghaus, D., Bergquist, A., ... Karlsen, T. H. (2011). Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci. Nature Genetics, 43(1), 17-19. https://doi.org/10.1038/ng.728

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title = "Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci",

abstract = "Primary sclerosing cholangitis (PSC) is a chronic bile duct disease affecting 2.4-7.5% of individuals with inflammatory bowel disease. We performed a genome-wide association analysis of 2,466,182 SNPs in 715 individuals with PSC and 2,962 controls, followed by replication in 1,025 PSC cases and 2,174 controls. We detected non-HLA associations at rs3197999 in MST1 and rs6720394 near BCL2L11 (combined P = 1.1 x 10(-16) and P = 4.1 x 10(-8), respectively)",

author = "Espen Melum and Andre Franke and Christoph Schramm and Weism{\"u}ller, {Tobias J.} and Gotthardt, {Daniel Nils} and Offner, {Felix A.} and Juran, {Brian D.} and Laerdahl, {Jon K.} and Verena Labi and Einar Bj{\"o}rnsson and Weersma, {Rinse K.} and Liesbet Henckaerts and Andreas Teufel and Christian Rust and Eva Ellinghaus and Tobias Balschun and Boberg, {Kirsten Muri} and David Ellinghaus and Annika Bergquist and Peter Sauer and Euijung Ryu and Hov, {Johannes Roksund} and Jochen Wedemeyer and Bj{\"o}rn Lindkvist and Michael Wittig and Porte, {Robert J.} and Kristian Holm and Christian Gieger and H.-Erich Wichmann and Pieter Stokkers and Ponsioen, {Cyriel Y.} and Heiko Runz and Adolf Stiehl and Cisca Wijmenga and Martina Sterneck and Severine Vermeire and Ulrich Beuers and Andreas Villunger and Erik Schrumpf and Lazaridis, {Konstantinos N.} and Manns, {Michael P.} and Stefan Schreiber and Karlsen, {Tom H.}",

year = "2011",

doi = "https://doi.org/10.1038/ng.728",

language = "English",

volume = "43",

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journal = "Nature Genetics",

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Melum, E, Franke, A, Schramm, C, Weismüller, TJ, Gotthardt, DN, Offner, FA, Juran, BD, Laerdahl, JK, Labi, V, Björnsson, E, Weersma, RK, Henckaerts, L, Teufel, A, Rust, C, Ellinghaus, E, Balschun, T, Boberg, KM, Ellinghaus, D, Bergquist, A, Sauer, P, Ryu, E, Hov, JR, Wedemeyer, J, Lindkvist, B, Wittig, M, Porte, RJ, Holm, K, Gieger, C, Wichmann, H-E, Stokkers, P, Ponsioen, CY, Runz, H, Stiehl, A, Wijmenga, C, Sterneck, M, Vermeire, S, Beuers, U, Villunger, A, Schrumpf, E, Lazaridis, KN, Manns, MP, Schreiber, S & Karlsen, TH 2011, 'Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci', Nature Genetics, vol. 43, no. 1, pp. 17-19. https://doi.org/10.1038/ng.728

TY - JOUR

T1 - Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci

AU - Melum, Espen

AU - Franke, Andre

AU - Schramm, Christoph

AU - Weismüller, Tobias J.

AU - Gotthardt, Daniel Nils

AU - Offner, Felix A.

AU - Juran, Brian D.

AU - Laerdahl, Jon K.

AU - Labi, Verena

AU - Björnsson, Einar

AU - Weersma, Rinse K.

AU - Henckaerts, Liesbet

AU - Teufel, Andreas

AU - Rust, Christian

AU - Ellinghaus, Eva

AU - Balschun, Tobias

AU - Boberg, Kirsten Muri

AU - Ellinghaus, David

AU - Bergquist, Annika

AU - Sauer, Peter

AU - Ryu, Euijung

AU - Hov, Johannes Roksund

AU - Wedemeyer, Jochen

AU - Lindkvist, Björn

AU - Wittig, Michael

AU - Porte, Robert J.

AU - Holm, Kristian

AU - Gieger, Christian

AU - Wichmann, H.-Erich

AU - Stokkers, Pieter

AU - Ponsioen, Cyriel Y.

AU - Runz, Heiko

AU - Stiehl, Adolf

AU - Wijmenga, Cisca

AU - Sterneck, Martina

AU - Vermeire, Severine

AU - Beuers, Ulrich

AU - Villunger, Andreas

AU - Schrumpf, Erik

AU - Lazaridis, Konstantinos N.

AU - Manns, Michael P.

AU - Schreiber, Stefan

AU - Karlsen, Tom H.

PY - 2011

Y1 - 2011

N2 - Primary sclerosing cholangitis (PSC) is a chronic bile duct disease affecting 2.4-7.5% of individuals with inflammatory bowel disease. We performed a genome-wide association analysis of 2,466,182 SNPs in 715 individuals with PSC and 2,962 controls, followed by replication in 1,025 PSC cases and 2,174 controls. We detected non-HLA associations at rs3197999 in MST1 and rs6720394 near BCL2L11 (combined P = 1.1 x 10(-16) and P = 4.1 x 10(-8), respectively)

AB - Primary sclerosing cholangitis (PSC) is a chronic bile duct disease affecting 2.4-7.5% of individuals with inflammatory bowel disease. We performed a genome-wide association analysis of 2,466,182 SNPs in 715 individuals with PSC and 2,962 controls, followed by replication in 1,025 PSC cases and 2,174 controls. We detected non-HLA associations at rs3197999 in MST1 and rs6720394 near BCL2L11 (combined P = 1.1 x 10(-16) and P = 4.1 x 10(-8), respectively)

U2 - https://doi.org/10.1038/ng.728

DO - https://doi.org/10.1038/ng.728

M3 - Article

C2 - 21151127

SN - 1061-4036

VL - 43

SP - 17

EP - 19

JO - Nature Genetics

JF - Nature Genetics

IS - 1

ER -