Genome-wide association studies of polygenic risk score-derived phenotypes may lead to inflated false positive rates

Emil Uffelmann; Danielle Posthuma; Wouter J. Peyrot

doi:https://doi.org/10.1038/s41598-023-29428-9

Genome-wide association studies of polygenic risk score-derived phenotypes may lead to inflated false positive rates

Emil Uffelmann, Danielle Posthuma, Wouter J. Peyrot

Research output: Contribution to journal › Letter › Academic › peer-review

2 Citations (Scopus)

Original language	English
Article number	4219
Pages (from-to)	4219
Journal	Scientific reports
Volume	13
Issue number	1
DOIs	https://doi.org/10.1038/s41598-023-29428-9
Publication status	Published - Dec 2023

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https://doi.org/10.1038/s41598-023-29428-9

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title = "Genome-wide association studies of polygenic risk score-derived phenotypes may lead to inflated false positive rates",

author = "Emil Uffelmann and Danielle Posthuma and Peyrot, {Wouter J.}",

note = "Funding Information: D.P. is supported by the Netherlands Organization for Scientific Research—Gravitation project {\textquoteleft}BRAINSCAPES: A Roadmap from Neurogenetics to Neurobiology{\textquoteright} (024.004.012) and the European Research Council advanced grant {\textquoteleft}From GWAS to Function{\textquoteright} (ERC-2018-ADG 834057). W.J.P is supported by a NWO Veni Grant (91619152).",

year = "2023",

month = dec,

doi = "https://doi.org/10.1038/s41598-023-29428-9",

language = "English",

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journal = "Scientific reports",

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T1 - Genome-wide association studies of polygenic risk score-derived phenotypes may lead to inflated false positive rates

AU - Uffelmann, Emil

AU - Posthuma, Danielle

AU - Peyrot, Wouter J.

N1 - Funding Information: D.P. is supported by the Netherlands Organization for Scientific Research—Gravitation project ‘BRAINSCAPES: A Roadmap from Neurogenetics to Neurobiology’ (024.004.012) and the European Research Council advanced grant ‘From GWAS to Function’ (ERC-2018-ADG 834057). W.J.P is supported by a NWO Veni Grant (91619152).

PY - 2023/12

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UR - https://www.ncbi.nlm.nih.gov/pubmed/36918594

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U2 - https://doi.org/10.1038/s41598-023-29428-9

DO - https://doi.org/10.1038/s41598-023-29428-9

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C2 - 36918594

SN - 2045-2322

VL - 13

SP - 4219

JO - Scientific reports

JF - Scientific reports

IS - 1

M1 - 4219

ER -

Genome-wide association studies of polygenic risk score-derived phenotypes may lead to inflated false positive rates

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