Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium

Cannabis Consortium; G. W. Montgomery; M. G. Nivard; I. M. Nolte; A. J. Oldehinkel; Z. Pausova; B. Qaiser; L. Quaye; J. A. Ramos-Quiroga; V. Richarte; R. J. Rose; J. Shin; M. C. Stallings; A. I. Stiby; T. L. Wall; M. J. Wright; H. M. Koot; T. Paus; J. K. Hewitt; M. Ribasés; J. Kaprio; H. Snieder; T. Spector; M. R. Munafò; A. Metspalu; J. Gelernter; D. I. Boomsma; W. G. Iacono; N. G. Martin; N. A. Gillespie; E. M. Derks

doi:https://doi.org/10.1038/tp.2016.36

Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium

Cannabis Consortium, G. W. Montgomery, M. G. Nivard, I. M. Nolte, A. J. Oldehinkel, Z. Pausova, B. Qaiser, L. Quaye, J. A. Ramos-Quiroga, V. Richarte, R. J. Rose, J. Shin, M. C. Stallings, A. I. Stiby, T. L. Wall, M. J. Wright, H. M. Koot, T. Paus, J. K. Hewitt, M. RibasésJ. Kaprio, H. Snieder, T. Spector, M. R. Munafò, A. Metspalu, J. Gelernter, D. I. Boomsma, W. G. Iacono, N. G. Martin, N. A. Gillespie, E. M. Derks

Research output: Contribution to journal › Article › Academic › peer-review

110 Citations (Scopus)

Abstract

Cannabis is the most widely produced and consumed illicit psychoactive substance worldwide. Occasional cannabis use can progress to frequent use, abuse and dependence with all known adverse physical, psychological and social consequences. Individual differences in cannabis initiation are heritable (40-48%). The International Cannabis Consortium was established with the aim to identify genetic risk variants of cannabis use. We conducted a meta-analysis of genome-wide association data of 13 cohorts (N=32 330) and four replication samples (N=5627). In addition, we performed a gene-based test of association, estimated single-nucleotide polymorphism (SNP)-based heritability and explored the genetic correlation between lifetime cannabis use and cigarette use using LD score regression. No individual SNPs reached genome-wide significance. Nonetheless, gene-based tests identified four genes significantly associated with lifetime cannabis use: NCAM1, CADM2, SCOC and KCNT2. Previous studies reported associations of NCAM1 with cigarette smoking and other substance use, and those of CADM2 with body mass index, processing speed and autism disorders, which are phenotypes previously reported to be associated with cannabis use. Furthermore, we showed that, combined across the genome, all common SNPs explained 13-20% (P

Original language	English
Pages (from-to)	e769
Journal	Translational Psychiatry
Volume	6
DOIs	https://doi.org/10.1038/tp.2016.36
Publication status	Published - 29 Mar 2016

Keywords

Adolescent
Adult
Aged
Aged, 80 and over
Antigens, CD56
Carrier Proteins
Cell Adhesion Molecules
Female
Genome-Wide Association Study
Humans
Journal Article
Male
Marijuana Abuse
Marijuana Smoking
Membrane Proteins
Meta-Analysis
Middle Aged
Potassium Channels
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Young Adult

Cohort Studies

Netherlands Twin Register (NTR)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

https://doi.org/10.1038/tp.2016.36

http://www.mendeley.com/research/genomewide-association-study-lifetime-cannabis-based-large-metaanalytic-sample-32-330-subjects-inter

Cite this

Cannabis Consortium, Montgomery, G. W., Nivard, M. G., Nolte, I. M., Oldehinkel, A. J., Pausova, Z., Qaiser, B., Quaye, L., Ramos-Quiroga, J. A., Richarte, V., Rose, R. J., Shin, J., Stallings, M. C., Stiby, A. I., Wall, T. L., Wright, M. J., Koot, H. M., Paus, T., Hewitt, J. K., ... Derks, E. M. (2016). Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium. Translational Psychiatry, 6, e769. https://doi.org/10.1038/tp.2016.36

@article{8d5a51a2cad94267b510880ef313e704,

title = "Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium",

abstract = "Cannabis is the most widely produced and consumed illicit psychoactive substance worldwide. Occasional cannabis use can progress to frequent use, abuse and dependence with all known adverse physical, psychological and social consequences. Individual differences in cannabis initiation are heritable (40-48%). The International Cannabis Consortium was established with the aim to identify genetic risk variants of cannabis use. We conducted a meta-analysis of genome-wide association data of 13 cohorts (N=32 330) and four replication samples (N=5627). In addition, we performed a gene-based test of association, estimated single-nucleotide polymorphism (SNP)-based heritability and explored the genetic correlation between lifetime cannabis use and cigarette use using LD score regression. No individual SNPs reached genome-wide significance. Nonetheless, gene-based tests identified four genes significantly associated with lifetime cannabis use: NCAM1, CADM2, SCOC and KCNT2. Previous studies reported associations of NCAM1 with cigarette smoking and other substance use, and those of CADM2 with body mass index, processing speed and autism disorders, which are phenotypes previously reported to be associated with cannabis use. Furthermore, we showed that, combined across the genome, all common SNPs explained 13-20% (P",

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author = "{Cannabis Consortium} and S. Stringer and Minic{\u a}, {C. C.} and Verweij, {K. J.H.} and H. Mbarek and M. Bernard and J. Derringer and {van Eijk}, {K. R.} and Isen, {J. D.} and A. Loukola and Maciejewski, {D. F.} and E. Mihailov and {van der Most}, {P. J.} and C. S{\'a}nchez-Mora and L. Roos and R. Sherva and R. Walters and Ware, {J. J.} and A. Abdellaoui and Bigdeli, {T. B.} and Branje, {S. J.T.} and Brown, {S. A.} and M. Bruinenberg and M. Casas and T. Esko and I. Garcia-Martinez and Gordon, {S. D.} and Harris, {J. M.} and Hartman, {C. A.} and Henders, {A. K.} and Heath, {A. C.} and Hickie, {I. B.} and M. Hickman and Hopfer, {C. J.} and Hottenga, {J. J.} and Huizink, {A. C.} and Irons, {D. E.} and Kahn, {R. S.} and T. Korhonen and Kranzler, {H. R.} and K. Krauter and {van Lier}, {P. A.C.} and Lubke, {G. H.} and Madden, {P. A.F.} and R. M{\"a}gi and McGue, {M. K.} and Medland, {S. E.} and Meeus, {W. H.J.} and Miller, {M. B.} and Boks, {M. P.} and Vink, {J. M.} and Montgomery, {G. W.} and Nivard, {M. G.} and Nolte, {I. M.} and Oldehinkel, {A. J.} and Z. Pausova and B. Qaiser and L. Quaye and Ramos-Quiroga, {J. A.} and V. Richarte and Rose, {R. J.} and J. Shin and Stallings, {M. C.} and Stiby, {A. I.} and Wall, {T. L.} and Wright, {M. J.} and Koot, {H. M.} and T. Paus and Hewitt, {J. K.} and M. Ribas{\'e}s and J. Kaprio and H. Snieder and T. Spector and Munaf{\`o}, {M. R.} and A. Metspalu and J. Gelernter and Boomsma, {D. I.} and Iacono, {W. G.} and Martin, {N. G.} and Gillespie, {N. A.} and Derks, {E. M.}",

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month = mar,

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doi = "https://doi.org/10.1038/tp.2016.36",

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Cannabis Consortium, Montgomery, GW, Nivard, MG, Nolte, IM, Oldehinkel, AJ, Pausova, Z, Qaiser, B, Quaye, L, Ramos-Quiroga, JA, Richarte, V, Rose, RJ, Shin, J, Stallings, MC, Stiby, AI, Wall, TL, Wright, MJ, Koot, HM, Paus, T, Hewitt, JK, Ribasés, M, Kaprio, J, Snieder, H, Spector, T, Munafò, MR, Metspalu, A, Gelernter, J, Boomsma, DI, Iacono, WG, Martin, NG, Gillespie, NA & Derks, EM 2016, 'Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium', Translational Psychiatry, vol. 6, pp. e769. https://doi.org/10.1038/tp.2016.36

TY - JOUR

T1 - Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium

AU - Cannabis Consortium

AU - Stringer, S.

AU - Minică, C. C.

AU - Verweij, K. J.H.

AU - Mbarek, H.

AU - Bernard, M.

AU - Derringer, J.

AU - van Eijk, K. R.

AU - Isen, J. D.

AU - Loukola, A.

AU - Maciejewski, D. F.

AU - Mihailov, E.

AU - van der Most, P. J.

AU - Sánchez-Mora, C.

AU - Roos, L.

AU - Sherva, R.

AU - Walters, R.

AU - Ware, J. J.

AU - Abdellaoui, A.

AU - Bigdeli, T. B.

AU - Branje, S. J.T.

AU - Brown, S. A.

AU - Bruinenberg, M.

AU - Casas, M.

AU - Esko, T.

AU - Garcia-Martinez, I.

AU - Gordon, S. D.

AU - Harris, J. M.

AU - Hartman, C. A.

AU - Henders, A. K.

AU - Heath, A. C.

AU - Hickie, I. B.

AU - Hickman, M.

AU - Hopfer, C. J.

AU - Hottenga, J. J.

AU - Huizink, A. C.

AU - Irons, D. E.

AU - Kahn, R. S.

AU - Korhonen, T.

AU - Kranzler, H. R.

AU - Krauter, K.

AU - van Lier, P. A.C.

AU - Lubke, G. H.

AU - Madden, P. A.F.

AU - Mägi, R.

AU - McGue, M. K.

AU - Medland, S. E.

AU - Meeus, W. H.J.

AU - Miller, M. B.

AU - Boks, M. P.

AU - Vink, J. M.

AU - Montgomery, G. W.

AU - Nivard, M. G.

AU - Nolte, I. M.

AU - Oldehinkel, A. J.

AU - Pausova, Z.

AU - Qaiser, B.

AU - Quaye, L.

AU - Ramos-Quiroga, J. A.

AU - Richarte, V.

AU - Rose, R. J.

AU - Shin, J.

AU - Stallings, M. C.

AU - Stiby, A. I.

AU - Wall, T. L.

AU - Wright, M. J.

AU - Koot, H. M.

AU - Paus, T.

AU - Hewitt, J. K.

AU - Ribasés, M.

AU - Kaprio, J.

AU - Snieder, H.

AU - Spector, T.

AU - Munafò, M. R.

AU - Metspalu, A.

AU - Gelernter, J.

AU - Boomsma, D. I.

AU - Iacono, W. G.

AU - Martin, N. G.

AU - Gillespie, N. A.

AU - Derks, E. M.

PY - 2016/3/29

Y1 - 2016/3/29

N2 - Cannabis is the most widely produced and consumed illicit psychoactive substance worldwide. Occasional cannabis use can progress to frequent use, abuse and dependence with all known adverse physical, psychological and social consequences. Individual differences in cannabis initiation are heritable (40-48%). The International Cannabis Consortium was established with the aim to identify genetic risk variants of cannabis use. We conducted a meta-analysis of genome-wide association data of 13 cohorts (N=32 330) and four replication samples (N=5627). In addition, we performed a gene-based test of association, estimated single-nucleotide polymorphism (SNP)-based heritability and explored the genetic correlation between lifetime cannabis use and cigarette use using LD score regression. No individual SNPs reached genome-wide significance. Nonetheless, gene-based tests identified four genes significantly associated with lifetime cannabis use: NCAM1, CADM2, SCOC and KCNT2. Previous studies reported associations of NCAM1 with cigarette smoking and other substance use, and those of CADM2 with body mass index, processing speed and autism disorders, which are phenotypes previously reported to be associated with cannabis use. Furthermore, we showed that, combined across the genome, all common SNPs explained 13-20% (P

AB - Cannabis is the most widely produced and consumed illicit psychoactive substance worldwide. Occasional cannabis use can progress to frequent use, abuse and dependence with all known adverse physical, psychological and social consequences. Individual differences in cannabis initiation are heritable (40-48%). The International Cannabis Consortium was established with the aim to identify genetic risk variants of cannabis use. We conducted a meta-analysis of genome-wide association data of 13 cohorts (N=32 330) and four replication samples (N=5627). In addition, we performed a gene-based test of association, estimated single-nucleotide polymorphism (SNP)-based heritability and explored the genetic correlation between lifetime cannabis use and cigarette use using LD score regression. No individual SNPs reached genome-wide significance. Nonetheless, gene-based tests identified four genes significantly associated with lifetime cannabis use: NCAM1, CADM2, SCOC and KCNT2. Previous studies reported associations of NCAM1 with cigarette smoking and other substance use, and those of CADM2 with body mass index, processing speed and autism disorders, which are phenotypes previously reported to be associated with cannabis use. Furthermore, we showed that, combined across the genome, all common SNPs explained 13-20% (P

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Antigens, CD56

KW - Carrier Proteins

KW - Cell Adhesion Molecules

KW - Female

KW - Genome-Wide Association Study

KW - Humans

KW - Journal Article

KW - Male

KW - Marijuana Abuse

KW - Marijuana Smoking

KW - Membrane Proteins

KW - Meta-Analysis

KW - Middle Aged

KW - Potassium Channels

KW - Research Support, N.I.H., Extramural

KW - Research Support, U.S. Gov't, Non-P.H.S.

KW - Young Adult

U2 - https://doi.org/10.1038/tp.2016.36

DO - https://doi.org/10.1038/tp.2016.36

M3 - Article

C2 - 27023175

SN - 2158-3188

VL - 6

SP - e769

JO - Translational Psychiatry

JF - Translational Psychiatry

ER -