Genome-wide Association Study Points to Novel Locus for Gilles de la Tourette Syndrome

The TIC Genetics Collaborative Group, The TSGeneSEE Initiative, the EMTICS Collaborative Group, The TS-EUROTRAIN Network, The PGC TS Working Group, The TSAICG, Tourette Syndrome Association International Consortium for Genetics (TSAICG)

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2 Citations (Scopus)

Abstract

Background: Tourette syndrome (TS) is a childhood-onset neurodevelopmental disorder of complex genetic architecture and is characterized by multiple motor tics and at least one vocal tic persisting for more than 1 year. Methods: We performed a genome-wide meta-analysis integrating a novel TS cohort with previously published data, resulting in a sample size of 6133 individuals with TS and 13,565 ancestry-matched control participants. Results: We identified a genome-wide significant locus on chromosome 5q15. Integration of expression quantitative trait locus, Hi-C (high-throughput chromosome conformation capture), and genome-wide association study data implicated the NR2F1 gene and associated long noncoding RNAs within the 5q15 locus. Heritability partitioning identified statistically significant enrichment in brain tissue histone marks, while polygenic risk scoring of brain volume data identified statistically significant associations with right and left thalamus volumes and right putamen volume. Conclusions: Our work presents novel insights into the neurobiology of TS, thereby opening up new directions for future studies.
Original languageEnglish
Number of pages11
JournalBiological Psychiatry
Early online date2 Feb 2023
DOIs
Publication statusPublished - Feb 2023

Keywords

  • GWAS
  • Meta-analysis
  • NR2F1
  • Tourette syndrome

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