TY - JOUR
T1 - Geometric mean IELT and premature ejaculation: appropriate statistics to avoid overestimation of treatment efficacy
AU - Waldinger, Marcel D.
AU - Zwinderman, Aeilko H.
AU - Olivier, Berend
AU - Schweitzer, Dave H.
PY - 2008
Y1 - 2008
N2 - INTRODUCTION: The intravaginal ejaculation latency time (IELT) behaves in a skewed manner and needs the appropriate statistics for correct interpretation of treatment results. AIMS: To explain the rightful use of geometrical mean IELT values and the fold increase of the geometric mean IELT because of the positively skewed IELT distribution. METHODS: Linking theoretical arguments to the outcome of several selective serotonin reuptake inhibitor and modern antidepressant study results. MAIN OUTCOME MEASURES: Geometric mean IELT and fold increase of geometrical mean IELT. RESULTS: Log-transforming each separate IELT measurement of each individual man is the basis for the calculation of the geometric mean IELT. A drug-induced positively skewed IELT distribution necessitates the calculation of the geometric mean IELTs at baseline and during drug treatment. In a positively skewed IELT distribution, the use of the "arithmetic" mean IELT risks an overestimation of the drug-induced ejaculation delay as the mean IELT is always higher than the geometric mean IELT. Strong ejaculation-delaying drugs give rise to a strong positively skewed IELT distribution, whereas weak ejaculation-delaying drugs give rise to (much) less skewed IELT distributions. Ejaculation delay is expressed in fold increase of the geometric mean IELT. CONCLUSIONS: Drug-induced ejaculatory performance discloses a positively skewed IELT distribution, requiring the use of the geometric mean IELT and the fold increase of the geometric mean IELT
AB - INTRODUCTION: The intravaginal ejaculation latency time (IELT) behaves in a skewed manner and needs the appropriate statistics for correct interpretation of treatment results. AIMS: To explain the rightful use of geometrical mean IELT values and the fold increase of the geometric mean IELT because of the positively skewed IELT distribution. METHODS: Linking theoretical arguments to the outcome of several selective serotonin reuptake inhibitor and modern antidepressant study results. MAIN OUTCOME MEASURES: Geometric mean IELT and fold increase of geometrical mean IELT. RESULTS: Log-transforming each separate IELT measurement of each individual man is the basis for the calculation of the geometric mean IELT. A drug-induced positively skewed IELT distribution necessitates the calculation of the geometric mean IELTs at baseline and during drug treatment. In a positively skewed IELT distribution, the use of the "arithmetic" mean IELT risks an overestimation of the drug-induced ejaculation delay as the mean IELT is always higher than the geometric mean IELT. Strong ejaculation-delaying drugs give rise to a strong positively skewed IELT distribution, whereas weak ejaculation-delaying drugs give rise to (much) less skewed IELT distributions. Ejaculation delay is expressed in fold increase of the geometric mean IELT. CONCLUSIONS: Drug-induced ejaculatory performance discloses a positively skewed IELT distribution, requiring the use of the geometric mean IELT and the fold increase of the geometric mean IELT
U2 - https://doi.org/10.1111/j.1743-6109.2007.00696.x
DO - https://doi.org/10.1111/j.1743-6109.2007.00696.x
M3 - Article
C2 - 18179458
SN - 1743-6095
VL - 5
SP - 492
EP - 499
JO - Journal of Sexual Medicine
JF - Journal of Sexual Medicine
IS - 2
ER -