TY - JOUR
T1 - GFR-estimation by serum creatinine during glucocorticosteroid therapy
AU - den Bakker, Emil
AU - Koene, Berend
AU - van Wijk, Joanna A. E.
AU - Hubeek, Isabelle
AU - Gemke, Reinoud
AU - Bökenkamp, Arend
PY - 2018
Y1 - 2018
N2 - Background: While glucocorticosteroids (GCS) are widely used in patients with kidney disease, little is known about their effect on serum creatinine, the most commonly used endogenous marker of kidney function. Methods: We assessed the effect of GCS on the relationship between estimated GFR using the Schwartz equation (eGFR) and measured GFR using a single-injection inulin clearance (Cin) in children both in a paired analysis and a cross-sectional study. Primary outcome variable was the difference between eGFR and Cin (ΔGFR) in a paired analysis involving 22 patients during and off GCS treatment (mean GFR 103.8 ml/min/1.73 m2, mean prednisone dose 34.8 mg/m2/day). In a cross-sectional analysis in 42 patients receiving GCS (mean dose of 25.7 mg/m2/day), a dose-dependent effect was explored using univariate and multivariate linear regression of various variables including GCS dosage with serum creatinine as dependent variable. Results: The paired analysis showed no significant difference in ΔGFR with or without GCS [− 23 (SD 53) vs. − 9 (SD 41) ml/min/1.73 m2, p = 0.203]. Stepwise multivariate linear regression analysis showed a significant correlation between age and Cin, while GCS dose was not related to serum creatinine. Conclusion: GCS use had no significant effect on serum creatinine as a marker for kidney function in a mixed population of renal outpatient clinic children.
AB - Background: While glucocorticosteroids (GCS) are widely used in patients with kidney disease, little is known about their effect on serum creatinine, the most commonly used endogenous marker of kidney function. Methods: We assessed the effect of GCS on the relationship between estimated GFR using the Schwartz equation (eGFR) and measured GFR using a single-injection inulin clearance (Cin) in children both in a paired analysis and a cross-sectional study. Primary outcome variable was the difference between eGFR and Cin (ΔGFR) in a paired analysis involving 22 patients during and off GCS treatment (mean GFR 103.8 ml/min/1.73 m2, mean prednisone dose 34.8 mg/m2/day). In a cross-sectional analysis in 42 patients receiving GCS (mean dose of 25.7 mg/m2/day), a dose-dependent effect was explored using univariate and multivariate linear regression of various variables including GCS dosage with serum creatinine as dependent variable. Results: The paired analysis showed no significant difference in ΔGFR with or without GCS [− 23 (SD 53) vs. − 9 (SD 41) ml/min/1.73 m2, p = 0.203]. Stepwise multivariate linear regression analysis showed a significant correlation between age and Cin, while GCS dose was not related to serum creatinine. Conclusion: GCS use had no significant effect on serum creatinine as a marker for kidney function in a mixed population of renal outpatient clinic children.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85048290246&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/29948443
U2 - https://doi.org/10.1007/s10157-018-1570-6
DO - https://doi.org/10.1007/s10157-018-1570-6
M3 - Article
C2 - 29948443
SN - 1342-1751
VL - 22
SP - 1163
EP - 1166
JO - Clinical and Experimental Nephrology
JF - Clinical and Experimental Nephrology
IS - 5
ER -