TY - JOUR
T1 - Global knowledge gaps on antimicrobial resistance in the human health sector
T2 - A scoping review
AU - Hamers, Raph L.
AU - Dobreva, Zlatina
AU - Cassini, Alessandro
AU - Tamara, Alice
AU - Lazarus, Gilbert
AU - Asadinia, Koe Stella
AU - Burzo, Stefano
AU - Olaru, Ioana Diana
AU - Dona, Daniele
AU - Emdin, Fiona
AU - van Weezenbeek, Kitty
AU - Bertagnolio, Silvia
N1 - Funding Information: The authors would like to acknowledge the contributions and suggestions of the World Health Organization (WHO) Core Steering Group for the Antimicrobial Resistance (AMR) Global Research Agenda in the Human Health Sector, in particular: Arno Mueller, Benedetta Allegranzi, Benedikt Huttner, Bruce Gordon, Carmem Pessoa, Dennis Falzon, Francis Moussy, Hatim Sati, Maarten van der Heijden, Mateusz Hasso-Agopsowicz, Miranda Deeves, Nebiat Gebreselassie, Rob Terry, Simone Moraes Raszl, Teodora Wi, Thomas Joseph, and Verica Ivanovska. The authors also thank Kartika Saraswati (KS), Rahajeng Tujungputri (RT), Ralalicia Limato (RL), and Elza Elmira (EE) for assistance in the literature searches and data extraction; and Sachiyo Yoshida and Igor Rudan for advice on the CHNRI methodology. SBe is the project leader. RLH, AC, and SBe conceptualized the project. RLH, AC, KSA, and SBe developed the protocol and search strategies. RLH, KSA, and AC designed and tested the data extraction tools. RLH, AT, AC, GL, KSA, and FE conducted the literature searches, extracted the data and formulated the knowledge gaps. RLH, ZD, AC, AT, GL, SBu, IDO, DD, FE, and SBe consolidated the knowledge gaps into thematic research questions. RLH, AT, and GL performed the data analysis and visualization, with input from ZD, SBu, IDO, and SBe. RLH drafted the manuscript, with critical input from AT, ZD, SBu, IDO, DD, KvW, and SBe. All authors critically reviewed the paper for important intellectual content and approved the final version of the manuscript. All data relevant to the study are included in the article or supplemental material. The complete annotated database of the included documents, knowledge gaps, and research questions can be downloaded from: https://github.com/gilbertlzrus/AMR-scoping-review/tree/8439c474899238b9b27ef3eb1ea2429a53c94301 Funding Information: This work is part of the project entitled “Global Research Agenda for Antimicrobial Resistance in the Human Health Sector” initiated and funded by the World Health Organization (WHO) Antimicrobial Resistance (AMR) Division (no award/grant number). The WHO was the funder of the study, and was responsible for study design, collection, analysis, and interpretation of the data, writing of the report, and the decision to submit the paper for publication. The first and corresponding authors had full access to all data and shared the final responsibility to submit for publication. Publisher Copyright: © 2023
PY - 2023/9/1
Y1 - 2023/9/1
N2 - Objectives: To identify and summarize existing global knowledge gaps on antimicrobial resistance (AMR) in human health, focusing on the World Health Organization (WHO) bacterial priority pathogens, Mycobacterium tuberculosis, and selected fungi. Methods: We conducted a scoping review of gray and peer-reviewed literature, published in English from January 2012 through December 2021, that reported on the prevention, diagnosis, treatment, and care of drug-resistant infections. We extracted relevant knowledge gaps and, through an iterative process, consolidated those into thematic research questions. Results: Of 8409 publications screened, 1156 were included, including 225 (19.5%) from low- and middle-income countries. A total of 2340 knowledge gaps were extracted, in the following areas: antimicrobial research and development, AMR burden and drivers, resistant tuberculosis, antimicrobial stewardship, diagnostics, infection prevention and control, antimicrobial consumption and use data, immunization, sexually transmitted infections, AMR awareness and education, policies and regulations, fungi, water sanitation and hygiene, and foodborne diseases. The knowledge gaps were consolidated into 177 research questions, including 78 (44.1%) specifically relevant to low- and middle-income countries and 65 (36.7%) targeting vulnerable populations. Conclusion: This scoping review presents the most comprehensive compilation of AMR-related knowledge gaps to date, informing a priority-setting exercise to develop the WHO Global AMR Research Agenda for the human health sector.
AB - Objectives: To identify and summarize existing global knowledge gaps on antimicrobial resistance (AMR) in human health, focusing on the World Health Organization (WHO) bacterial priority pathogens, Mycobacterium tuberculosis, and selected fungi. Methods: We conducted a scoping review of gray and peer-reviewed literature, published in English from January 2012 through December 2021, that reported on the prevention, diagnosis, treatment, and care of drug-resistant infections. We extracted relevant knowledge gaps and, through an iterative process, consolidated those into thematic research questions. Results: Of 8409 publications screened, 1156 were included, including 225 (19.5%) from low- and middle-income countries. A total of 2340 knowledge gaps were extracted, in the following areas: antimicrobial research and development, AMR burden and drivers, resistant tuberculosis, antimicrobial stewardship, diagnostics, infection prevention and control, antimicrobial consumption and use data, immunization, sexually transmitted infections, AMR awareness and education, policies and regulations, fungi, water sanitation and hygiene, and foodborne diseases. The knowledge gaps were consolidated into 177 research questions, including 78 (44.1%) specifically relevant to low- and middle-income countries and 65 (36.7%) targeting vulnerable populations. Conclusion: This scoping review presents the most comprehensive compilation of AMR-related knowledge gaps to date, informing a priority-setting exercise to develop the WHO Global AMR Research Agenda for the human health sector.
KW - Antimicrobial resistance
KW - Bacteria
KW - Fungi
KW - Knowledge gaps
KW - Scoping review
KW - Tuberculosis
UR - http://www.scopus.com/inward/record.url?scp=85163143582&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.ijid.2023.06.004
DO - https://doi.org/10.1016/j.ijid.2023.06.004
M3 - Review article
C2 - 37301361
SN - 1201-9712
VL - 134
SP - 142
EP - 149
JO - International Journal of Infectious Diseases
JF - International Journal of Infectious Diseases
ER -