TY - JOUR
T1 - Glomerular hyperfiltration
T2 - part 2—clinical significance in children
AU - Adebayo, Oyindamola C.
AU - Nkoy, Agathe B.
AU - van den Heuvel, Lambertus P.
AU - Labarque, Veerle
AU - Levtchenko, Elena
AU - Delanaye, Pierre
AU - Pottel, Hans
N1 - Funding Information: O.C.A. is supported by the fundamental research grant of Fonds Wetenschappelijk Onderzoek-Vlaanderen (FWO) [grant number 11A5621N]. A.B.N is supported by the Global Minds Scholarship of VLIR-UOS and DGD (Belgium partner in development). Publisher Copyright: © 2022, The Author(s), under exclusive licence to International Pediatric Nephrology Association.
PY - 2022
Y1 - 2022
N2 - Glomerular hyperfiltration (GHF) is a phenomenon that can occur in various clinical conditions affecting the kidneys such as sickle cell disease, diabetes mellitus, autosomal dominant polycystic kidney disease, and solitary functioning kidney. Yet, the pathophysiological mechanisms vary from one disease to another and are not well understood. More so, it has been demonstrated that GHF may occur at the single-nephron in some clinical conditions while in others at the whole-kidney level. In this review, we explore the pathophysiological mechanisms of GHF in relation to various clinical conditions in the pediatric population. In addition, we discuss the role and mechanism of action of important factors such as gender, low birth weight, and race in the pathogenesis of GHF. Finally, in this current review, we further highlight the consequences of GHF in the progression of kidney disease.
AB - Glomerular hyperfiltration (GHF) is a phenomenon that can occur in various clinical conditions affecting the kidneys such as sickle cell disease, diabetes mellitus, autosomal dominant polycystic kidney disease, and solitary functioning kidney. Yet, the pathophysiological mechanisms vary from one disease to another and are not well understood. More so, it has been demonstrated that GHF may occur at the single-nephron in some clinical conditions while in others at the whole-kidney level. In this review, we explore the pathophysiological mechanisms of GHF in relation to various clinical conditions in the pediatric population. In addition, we discuss the role and mechanism of action of important factors such as gender, low birth weight, and race in the pathogenesis of GHF. Finally, in this current review, we further highlight the consequences of GHF in the progression of kidney disease.
KW - Autosomal dominant polycystic kidney disease (ADPKD)
KW - Diabetic kidney disease
KW - Duchenne muscular dystrophy
KW - Glomerular hyperfiltration
KW - Obesity-related glomerulopathy
KW - Pediatric population
KW - Sickle cell disease
KW - Solitary functioning kidney
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85143398468&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/36472656
U2 - https://doi.org/10.1007/s00467-022-05826-5
DO - https://doi.org/10.1007/s00467-022-05826-5
M3 - Review article
C2 - 36472656
SN - 0931-041X
JO - Pediatric nephrology (Berlin, Germany)
JF - Pediatric nephrology (Berlin, Germany)
ER -