Glucocorticoids and relapse of major depression (dexamethasone/corticotropin-releasing hormone test in relation to relapse of major depression)

Bente C. Appelhof; Jochanan Huyser; Mijke Verweij; Jantien P. Brouwer; Richard van Dyck; Eric Fliers; Witte J. G. Hoogendijk; Jan G. P. Tijssen; Wilmar M. Wiersinga; Aart H. Schene

doi:https://doi.org/10.1016/j.biopsych.2005.09.008

Glucocorticoids and relapse of major depression (dexamethasone/corticotropin-releasing hormone test in relation to relapse of major depression)

Bente C. Appelhof, Jochanan Huyser, Mijke Verweij, Jantien P. Brouwer, Richard van Dyck, Eric Fliers, Witte J. G. Hoogendijk, Jan G. P. Tijssen, Wilmar M. Wiersinga, Aart H. Schene

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

BACKGROUND: Knowledge of pathogenic mechanisms and predictors of relapse in major depressive disorder is still limited. Hypothalamic-pituitary-adrenocortical (HPA) axis dysregulation is thought to be related to the development and course of depression. METHODS: We investigated whether dexamethasone/corticotropin-releasing hormone (DEX/CRH) test parameters were related to the occurrence of relapse in 45 outpatients with clinically remitted major depression. The DEX/CRH test was administered before and after 8 weeks of antidepressant treatment. RESULTS: Posttreatment maximal adrenocorticotropic hormone (ACTH) and maximal cortisol levels, as well as delta ACTH and delta cortisol levels, were significantly higher (all p < .05) among patients who relapsed (n = 22) compared with patients in whom no relapse occurred (n = 23). Higher posttreatment maximal cortisol response on the DEX/CRH test was associated with shorter "relapse-free survival" (p = .05). CONCLUSIONS: In outpatients with clinically remitted major depression, higher posttreatment maximal cortisol levels on the DEX/CRH test were associated with relapse of major depression

Original language	English
Pages (from-to)	696-701
Journal	Biological Psychiatry
Volume	59
Issue number	8
DOIs	https://doi.org/10.1016/j.biopsych.2005.09.008
Publication status	Published - 2006

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https://doi.org/10.1016/j.biopsych.2005.09.008

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Appelhof, B. C., Huyser, J., Verweij, M., Brouwer, J. P., van Dyck, R., Fliers, E., Hoogendijk, W. J. G., Tijssen, J. G. P., Wiersinga, W. M., & Schene, A. H. (2006). Glucocorticoids and relapse of major depression (dexamethasone/corticotropin-releasing hormone test in relation to relapse of major depression). Biological Psychiatry, 59(8), 696-701. https://doi.org/10.1016/j.biopsych.2005.09.008

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title = "Glucocorticoids and relapse of major depression (dexamethasone/corticotropin-releasing hormone test in relation to relapse of major depression)",

abstract = "BACKGROUND: Knowledge of pathogenic mechanisms and predictors of relapse in major depressive disorder is still limited. Hypothalamic-pituitary-adrenocortical (HPA) axis dysregulation is thought to be related to the development and course of depression. METHODS: We investigated whether dexamethasone/corticotropin-releasing hormone (DEX/CRH) test parameters were related to the occurrence of relapse in 45 outpatients with clinically remitted major depression. The DEX/CRH test was administered before and after 8 weeks of antidepressant treatment. RESULTS: Posttreatment maximal adrenocorticotropic hormone (ACTH) and maximal cortisol levels, as well as delta ACTH and delta cortisol levels, were significantly higher (all p < .05) among patients who relapsed (n = 22) compared with patients in whom no relapse occurred (n = 23). Higher posttreatment maximal cortisol response on the DEX/CRH test was associated with shorter {"}relapse-free survival{"} (p = .05). CONCLUSIONS: In outpatients with clinically remitted major depression, higher posttreatment maximal cortisol levels on the DEX/CRH test were associated with relapse of major depression",

author = "Appelhof, {Bente C.} and Jochanan Huyser and Mijke Verweij and Brouwer, {Jantien P.} and {van Dyck}, Richard and Eric Fliers and Hoogendijk, {Witte J. G.} and Tijssen, {Jan G. P.} and Wiersinga, {Wilmar M.} and Schene, {Aart H.}",

year = "2006",

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language = "English",

volume = "59",

pages = "696--701",

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Appelhof, BC, Huyser, J, Verweij, M, Brouwer, JP, van Dyck, R, Fliers, E, Hoogendijk, WJG, Tijssen, JGP, Wiersinga, WM & Schene, AH 2006, 'Glucocorticoids and relapse of major depression (dexamethasone/corticotropin-releasing hormone test in relation to relapse of major depression)', Biological Psychiatry, vol. 59, no. 8, pp. 696-701. https://doi.org/10.1016/j.biopsych.2005.09.008

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T1 - Glucocorticoids and relapse of major depression (dexamethasone/corticotropin-releasing hormone test in relation to relapse of major depression)

AU - Appelhof, Bente C.

AU - Huyser, Jochanan

AU - Verweij, Mijke

AU - Brouwer, Jantien P.

AU - van Dyck, Richard

AU - Fliers, Eric

AU - Hoogendijk, Witte J. G.

AU - Tijssen, Jan G. P.

AU - Wiersinga, Wilmar M.

AU - Schene, Aart H.

PY - 2006

Y1 - 2006

N2 - BACKGROUND: Knowledge of pathogenic mechanisms and predictors of relapse in major depressive disorder is still limited. Hypothalamic-pituitary-adrenocortical (HPA) axis dysregulation is thought to be related to the development and course of depression. METHODS: We investigated whether dexamethasone/corticotropin-releasing hormone (DEX/CRH) test parameters were related to the occurrence of relapse in 45 outpatients with clinically remitted major depression. The DEX/CRH test was administered before and after 8 weeks of antidepressant treatment. RESULTS: Posttreatment maximal adrenocorticotropic hormone (ACTH) and maximal cortisol levels, as well as delta ACTH and delta cortisol levels, were significantly higher (all p < .05) among patients who relapsed (n = 22) compared with patients in whom no relapse occurred (n = 23). Higher posttreatment maximal cortisol response on the DEX/CRH test was associated with shorter "relapse-free survival" (p = .05). CONCLUSIONS: In outpatients with clinically remitted major depression, higher posttreatment maximal cortisol levels on the DEX/CRH test were associated with relapse of major depression

AB - BACKGROUND: Knowledge of pathogenic mechanisms and predictors of relapse in major depressive disorder is still limited. Hypothalamic-pituitary-adrenocortical (HPA) axis dysregulation is thought to be related to the development and course of depression. METHODS: We investigated whether dexamethasone/corticotropin-releasing hormone (DEX/CRH) test parameters were related to the occurrence of relapse in 45 outpatients with clinically remitted major depression. The DEX/CRH test was administered before and after 8 weeks of antidepressant treatment. RESULTS: Posttreatment maximal adrenocorticotropic hormone (ACTH) and maximal cortisol levels, as well as delta ACTH and delta cortisol levels, were significantly higher (all p < .05) among patients who relapsed (n = 22) compared with patients in whom no relapse occurred (n = 23). Higher posttreatment maximal cortisol response on the DEX/CRH test was associated with shorter "relapse-free survival" (p = .05). CONCLUSIONS: In outpatients with clinically remitted major depression, higher posttreatment maximal cortisol levels on the DEX/CRH test were associated with relapse of major depression

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DO - https://doi.org/10.1016/j.biopsych.2005.09.008

M3 - Article

C2 - 16368077

SN - 0006-3223

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