Glutamate dehydrogenase contributes to leucine sensing in the regulation of autophagy

Séverine Lorin; Marc J. Tol; Chantal Bauvy; Anneke Strijland; Christian Poüs; Arthur J. Verhoeven; Patrice Codogno; Alfred J. Meijer

doi:https://doi.org/10.4161/auto.24083

Glutamate dehydrogenase contributes to leucine sensing in the regulation of autophagy

Séverine Lorin, Marc J. Tol, Chantal Bauvy, Anneke Strijland, Christian Poüs, Arthur J. Verhoeven, Patrice Codogno, Alfred J. Meijer

Research output: Contribution to journal › Article › Academic › peer-review

57 Citations (Scopus)

Abstract

Amino acids, leucine in particular, are known to inhibit autophagy, at least in part by their ability to stimulate MTOR-mediated signaling. Evidence is presented showing that glutamate dehydrogenase, the central enzyme in amino acid catabolism, contributes to leucine sensing in the regulation of autophagy. The data suggest a dual mechanism by which glutamate dehydrogenase activity modulates autophagy, i.e., by activating MTORC1 and by limiting the formation of reactive oxygen species

Original language	English
Pages (from-to)	850-860
Journal	Autophagy
Volume	9
Issue number	6
DOIs	https://doi.org/10.4161/auto.24083
Publication status	Published - 2013

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https://doi.org/10.4161/auto.24083

Cite this

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title = "Glutamate dehydrogenase contributes to leucine sensing in the regulation of autophagy",

abstract = "Amino acids, leucine in particular, are known to inhibit autophagy, at least in part by their ability to stimulate MTOR-mediated signaling. Evidence is presented showing that glutamate dehydrogenase, the central enzyme in amino acid catabolism, contributes to leucine sensing in the regulation of autophagy. The data suggest a dual mechanism by which glutamate dehydrogenase activity modulates autophagy, i.e., by activating MTORC1 and by limiting the formation of reactive oxygen species",

author = "S{\'e}verine Lorin and Tol, {Marc J.} and Chantal Bauvy and Anneke Strijland and Christian Po{\"u}s and Verhoeven, {Arthur J.} and Patrice Codogno and Meijer, {Alfred J.}",

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AU - Lorin, Séverine

AU - Tol, Marc J.

AU - Bauvy, Chantal

AU - Strijland, Anneke

AU - Poüs, Christian

AU - Verhoeven, Arthur J.

AU - Codogno, Patrice

AU - Meijer, Alfred J.

PY - 2013

Y1 - 2013

N2 - Amino acids, leucine in particular, are known to inhibit autophagy, at least in part by their ability to stimulate MTOR-mediated signaling. Evidence is presented showing that glutamate dehydrogenase, the central enzyme in amino acid catabolism, contributes to leucine sensing in the regulation of autophagy. The data suggest a dual mechanism by which glutamate dehydrogenase activity modulates autophagy, i.e., by activating MTORC1 and by limiting the formation of reactive oxygen species

AB - Amino acids, leucine in particular, are known to inhibit autophagy, at least in part by their ability to stimulate MTOR-mediated signaling. Evidence is presented showing that glutamate dehydrogenase, the central enzyme in amino acid catabolism, contributes to leucine sensing in the regulation of autophagy. The data suggest a dual mechanism by which glutamate dehydrogenase activity modulates autophagy, i.e., by activating MTORC1 and by limiting the formation of reactive oxygen species

U2 - https://doi.org/10.4161/auto.24083

DO - https://doi.org/10.4161/auto.24083

M3 - Article

C2 - 23575388

SN - 1554-8627

VL - 9

SP - 850

EP - 860

JO - Autophagy

JF - Autophagy

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