TY - JOUR
T1 - GRADE Guidance: 31. Assessing the certainty across a body of evidence for comparative test accuracy
AU - Yang, Bada
AU - Mustafa, Reem A.
AU - Bossuyt, Patrick M.
AU - Brozek, Jan
AU - Hultcrantz, Monica
AU - Leeflang, Mariska M. G.
AU - Schünemann, Holger J.
AU - Langendam, Miranda W.
N1 - Funding Information: Funding: Amsterdam UMC, the AMC foundation (The Netherlands), the Michael G. De Groote Cochrane Canada and McMaster GRADE centres provided funding for this project. The funding organizations had no role in the design, collection, analysis, and interpretation of the data or the decision to approve publication of the finished manuscript. Publisher Copyright: © 2021 The Author(s)
PY - 2021/8/1
Y1 - 2021/8/1
N2 - Objectives: This article provides GRADE guidance on how authors of evidence syntheses and health decision makers, including guideline developers, can rate the certainty across a body of evidence for comparative test accuracy questions. Study design and setting: This guidance extends the previously published GRADE guidance for assessing certainty of evidence for test accuracy to scenarios in which two or more index tests are compared. Through an iterative brainstorm-discussion-feedback process within the GRADE working group, we developed a guidance accompanied by practical examples. Results: Rating the certainty of evidence for comparative test accuracy shares many concepts and ideas with the existing GRADE guidance for test accuracy. The rating in comparisons of test accuracy requires additional considerations, such as the selection of appropriate comparative study designs, additional criteria for judging risk of bias, and the consequences of using comparative measures of test accuracy. Distinct approaches to rating certainty are required for comparative test accuracy studies and between-study (indirect) comparisons. Conclusion: This GRADE guidance will support transparent assessment of the certainty for a body of comparative test accuracy evidence.
AB - Objectives: This article provides GRADE guidance on how authors of evidence syntheses and health decision makers, including guideline developers, can rate the certainty across a body of evidence for comparative test accuracy questions. Study design and setting: This guidance extends the previously published GRADE guidance for assessing certainty of evidence for test accuracy to scenarios in which two or more index tests are compared. Through an iterative brainstorm-discussion-feedback process within the GRADE working group, we developed a guidance accompanied by practical examples. Results: Rating the certainty of evidence for comparative test accuracy shares many concepts and ideas with the existing GRADE guidance for test accuracy. The rating in comparisons of test accuracy requires additional considerations, such as the selection of appropriate comparative study designs, additional criteria for judging risk of bias, and the consequences of using comparative measures of test accuracy. Distinct approaches to rating certainty are required for comparative test accuracy studies and between-study (indirect) comparisons. Conclusion: This GRADE guidance will support transparent assessment of the certainty for a body of comparative test accuracy evidence.
KW - Certainty of evidence
KW - Diagnostic accuracy
KW - GRADE
KW - Methodology
KW - Test comparison
UR - http://www.scopus.com/inward/record.url?scp=85110744141&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.jclinepi.2021.04.001
DO - https://doi.org/10.1016/j.jclinepi.2021.04.001
M3 - Article
C2 - 33864930
SN - 0895-4356
VL - 136
SP - 146
EP - 156
JO - Journal of Clinical Epidemiology
JF - Journal of Clinical Epidemiology
ER -