@article{1ddf16b782f541fda1c1cb2f50f2d496,
title = "Harnessing developmental cues for cardiomyocyte production",
abstract = "Developmental research has attempted to untangle the exact signals that control heart growth and size, with knockout studies in mice identifying pivotal roles for Wnt and Hippo signaling during embryonic and fetal heart growth. Despite this improved understanding, no clinically relevant therapies are yet available to compensate for the loss of functional adult myocardium and the absence of mature cardiomyocyte renewal that underlies cardiomyopathies of multiple origins. It remains of great interest to understand which mechanisms are responsible for the decline in proliferation in adult hearts and to elucidate new strategies for the stimulation of cardiac regeneration. Multiple signaling pathways have been identified that regulate the proliferation of cardiomyocytes in the embryonic heart and appear to be upregulated in postnatal injured hearts. In this Review, we highlight the interaction of signaling pathways in heart development and discuss how this knowledge has been translated into current technologies for cardiomyocyte production.",
keywords = "Cardiomyocyte production, Cardiomyocyte proliferation, Cardiomyocyte self-renewal, Embryonic growth pathways, Fetal gene program, Heart regeneration, Hippo signaling, Wnt signaling, hiPSC-CM",
author = "Maas, {Renee G. C.} and {van den Dolder}, {Floor W.} and Qianliang Yuan and {van der Velden}, Jolanda and Wu, {Sean M.} and Sluijter, {Joost P. G.} and Buikema, {Jan W.}",
note = "Funding Information: R.G.C.M. is supported by a fellowship from the Stichting PLN. F.W.v.d.D. acknowledges support from the Dutch Cardiovascular Alliance. Q.Y. is supported by PhD fellowship from China Scholarship Council (201706170068). J.v.d.V. is supported by grants from Nederlandse Organisatie voor Wetenschappelijk Onderzoek–ZonMw (91818602 VICI), ZonMw and Hartstichting for the translational research program, project 95105003; the Dutch Cardiovascular Alliance grant Double Dose 2021; the Fondation Leducq grant number 20CVD01; and Proper Therapy project funded by the Nederlandse Organisatie voor Wetenschappelijk Onderzoek, domain Applied and Engineering Sciences (NWO-AES), the Association of Collaborating Health Foundations (Health~Holland), and ZonMw within the human models 2.0 call. S.M.W. is supported by the National Institutes of Health/National Institute of General Medical Sciences (1RM1GM131981-03); American Heart Association Established Investigator Award; Additional Ventures Foundation; National Science Foundation RECODE Project; and the Joan and Sanford I. Weill Department of Medicine Endowed Scholarship Fund. J.P.G.S. is supported by H2020-EVICARE (725229) of the European Research Council and ZonMw PSIDER grant (10250022110004). J.W.B. is supported by a Dekker Senior Clinical Scientist personal grant from the Hartstichting; Netherlands Heart Institute Fellowship; and CVON-Dosis young talent grant from the Hartstichting (CVON-Dosis 2014–40). Deposited in PMC for release after 12 months. Publisher Copyright: {\textcopyright} 2023. Published by The Company of Biologists Ltd.",
year = "2023",
month = aug,
day = "1",
doi = "https://doi.org/10.1242/dev.201483",
language = "English",
volume = "150",
journal = "Development (Cambridge, England)",
issn = "0950-1991",
publisher = "Company of Biologists Ltd",
number = "15",
}