TY - JOUR
T1 - HDL-mimetic PLGA nanoparticle to target atherosclerosis plaque macrophages
AU - Sanchez-Gaytan, Brenda L.
AU - Fay, Francois
AU - Lobatto, Mark E.
AU - Tang, Jun
AU - Ouimet, Mireille
AU - Kim, Yongtae
AU - van der Staay, Susanne E. M.
AU - van Rijs, Sarian M.
AU - Priem, Bram
AU - Zhang, Liangfang
AU - Fisher, Edward A.
AU - Moore, Kathryn J.
AU - Langer, Robert
AU - Fayad, Zahi A.
AU - Mulder, Willem J. M.
PY - 2015
Y1 - 2015
N2 - High-density lipoprotein (HDL) is a natural nanoparticle that exhibits an intrinsic affinity for atherosclerotic plaque macrophages. Its natural targeting capability as well as the option to incorporate lipophilic payloads, e.g., imaging or therapeutic components, in both the hydrophobic core and the phospholipid corona make the HDL platform an attractive nanocarrier. To realize controlled release properties, we developed a hybrid polymer/HDL nanoparticle composed of a lipid/apolipoprotein coating that encapsulates a poly(lactic-co-glycolic acid) (PLGA) core. This novel HDL-like nanoparticle (PLGA-HDL) displayed natural HDL characteristics, including preferential uptake by macrophages and a good cholesterol efflux capacity, combined with a typical PLGA nanoparticle slow release profile. In vivo studies carried out with an ApoE knockout mouse model of atherosclerosis showed clear accumulation of PLGA-HDL nanoparticles in atherosclerotic plaques, which colocalized with plaque macrophages. This biomimetic platform integrates the targeting capacity of HDL biomimetic nanoparticles with the characteristic versatility of PLGA-based nanocarriers
AB - High-density lipoprotein (HDL) is a natural nanoparticle that exhibits an intrinsic affinity for atherosclerotic plaque macrophages. Its natural targeting capability as well as the option to incorporate lipophilic payloads, e.g., imaging or therapeutic components, in both the hydrophobic core and the phospholipid corona make the HDL platform an attractive nanocarrier. To realize controlled release properties, we developed a hybrid polymer/HDL nanoparticle composed of a lipid/apolipoprotein coating that encapsulates a poly(lactic-co-glycolic acid) (PLGA) core. This novel HDL-like nanoparticle (PLGA-HDL) displayed natural HDL characteristics, including preferential uptake by macrophages and a good cholesterol efflux capacity, combined with a typical PLGA nanoparticle slow release profile. In vivo studies carried out with an ApoE knockout mouse model of atherosclerosis showed clear accumulation of PLGA-HDL nanoparticles in atherosclerotic plaques, which colocalized with plaque macrophages. This biomimetic platform integrates the targeting capacity of HDL biomimetic nanoparticles with the characteristic versatility of PLGA-based nanocarriers
U2 - https://doi.org/10.1021/bc500517k
DO - https://doi.org/10.1021/bc500517k
M3 - Article
C2 - 25650634
SN - 1043-1802
VL - 26
SP - 443
EP - 451
JO - Bioconjugate chemistry
JF - Bioconjugate chemistry
IS - 3
ER -