TY - JOUR
T1 - Health-economic evaluation of psychological interventions for depression prevention: Systematic review
AU - Conejo-Cerón, Sonia
AU - Lokkerbol, Joran
AU - Moreno-Peral, Patricia
AU - Wijnen, Ben
AU - Fernández, Anna
AU - Mendive, Juan M.
AU - Smit, Filip
AU - Bellón, Juan Ángel
N1 - Funding Information: This work is supported by the Spanish Ministry of Health , the Institute of Health Carlos III and the European Regional Development Fund «Una manera de hacer Europa» (grant FIS reference: PI15/00401 ; PI15-01035 ; PI15-01021 ) and the Andalusian Council of Health (grant reference: AP-0095-2016 ; grant reference: EF-0286-2018 ); as well as by the Prevention and Health Promotion Research Network ‘redIAPP’ ( RD16/0007 ). The funders of the study had no role in the study design, data collection, data analysis, data interpretation, or the writing of the report. Publisher Copyright: © 2021 Elsevier Ltd Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/8/1
Y1 - 2021/8/1
N2 - Psychological interventions have been proven to be effective to prevent depression, however, little is known on the cost-effectiveness of psychological interventions for the prevention of depression in various populations. A systematic review was conducted using PubMed, PsycINFO, Web of Science, Embase, Cochrane Central Register of Controlled Trials, Econlit, NHS Economic Evaluations Database, NHS Health Technology Assessment and OpenGrey up to January 2021. Only health-economic evaluations based on randomized controlled trials of psychological interventions to prevent depression were included. Independent evaluators selected studies, extracted data and assessed the quality using the Consensus on Health Economic Criteria and the Cochrane Risk of Bias Tool. Twelve trial-based economic evaluations including 5929 participants from six different countries met the inclusion criteria. Overall, the quality of most economic evaluations was considered good, but some studies have some risk of bias. Setting the willingness-to-pay upper limit to US$40,000 (2018 prices) for gaining one quality adjusted life year (QALY), eight psychological preventive interventions were likely to be cost-effective compared to care as usual. The likelihood of preventive psychological interventions being more cost-effective than care as usual looks promising, but more economic evaluations are needed to bridge the many gaps that remain in the evidence-base. Ethics: As this systematic review is based on published data, approval from the local ethics committee was not required.
AB - Psychological interventions have been proven to be effective to prevent depression, however, little is known on the cost-effectiveness of psychological interventions for the prevention of depression in various populations. A systematic review was conducted using PubMed, PsycINFO, Web of Science, Embase, Cochrane Central Register of Controlled Trials, Econlit, NHS Economic Evaluations Database, NHS Health Technology Assessment and OpenGrey up to January 2021. Only health-economic evaluations based on randomized controlled trials of psychological interventions to prevent depression were included. Independent evaluators selected studies, extracted data and assessed the quality using the Consensus on Health Economic Criteria and the Cochrane Risk of Bias Tool. Twelve trial-based economic evaluations including 5929 participants from six different countries met the inclusion criteria. Overall, the quality of most economic evaluations was considered good, but some studies have some risk of bias. Setting the willingness-to-pay upper limit to US$40,000 (2018 prices) for gaining one quality adjusted life year (QALY), eight psychological preventive interventions were likely to be cost-effective compared to care as usual. The likelihood of preventive psychological interventions being more cost-effective than care as usual looks promising, but more economic evaluations are needed to bridge the many gaps that remain in the evidence-base. Ethics: As this systematic review is based on published data, approval from the local ethics committee was not required.
KW - Prevention
KW - cost-effectiveness
KW - depression
KW - psychological interventions
UR - http://www.scopus.com/inward/record.url?scp=85111065562&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.cpr.2021.102064
DO - https://doi.org/10.1016/j.cpr.2021.102064
M3 - Review article
C2 - 34304111
SN - 0272-7358
VL - 88
JO - Clinical psychology review
JF - Clinical psychology review
M1 - 102064
ER -