TY - JOUR
T1 - Hearing loss after platinum treatment is irreversible in noncranial irradiated childhood cancer survivors
AU - Clemens, Eva
AU - de Vries, Andrica C.H.
AU - am Zehnhoff-Dinnesen, Antoinette
AU - Tissing, Wim J.E.
AU - Loonen, Jacqueline J.
AU - Pluijm, Saskia F.M.
AU - van Dulmen-den Broeder, Eline
AU - Bresters, Dorine
AU - Versluys, Birgitta
AU - Kremer, Leontien C.M.
AU - van der Pal, Helena J.
AU - Neggers, Sebastian J.C.C.M.
AU - van Grotel, Martine
AU - M van den Heuvel-Eibrink, Marry
PY - 2017/2/17
Y1 - 2017/2/17
N2 - Cisplatin and carboplatin are effective antineoplastic agents. They are also considered to be potentially highly ototoxic. To date, no long-term follow-up data from well-documented cohorts with substantial numbers of childhood cancer survivors (CCS) with platinum-related hearing loss are available. Therefore, in this study, we studied the reversibility of ototoxicity from discontinuation of treatment onwards in a national cohort of platinum-treated survivors with hearing loss at the end of cancer treatment. Of the 168 CCS with follow-up audiograms, we longitudinally evaluated the course of hearing function in 61 CCS who showed hearing impairment at discontinuation of treatment according to the Münster criteria (>20 dB at ≥4–8 kHz). Survivors were treated with platinum (median total cumulative dose cisplatin: 480 mg/m2 and median total cumulative dose carboplatin: 2520 mg/m2). Median follow-up time was 5.5 years (range: 1.0–28.8 years). The results showed that none of these survivors revealed improvement of hearing function even till 28.8 years after discontinuation of treatment (grade <2b during long-term follow-up). An increase in hearing loss with two or three Münster degrees was observed in five of 61 survivors after 1.6–19.6 years. Overall, this indicates that ototoxicity after platinum treatment may be irreversible and that longitudinal clinical audiological monitoring and care is required in long-term survivors of childhood cancer on a large scale.
AB - Cisplatin and carboplatin are effective antineoplastic agents. They are also considered to be potentially highly ototoxic. To date, no long-term follow-up data from well-documented cohorts with substantial numbers of childhood cancer survivors (CCS) with platinum-related hearing loss are available. Therefore, in this study, we studied the reversibility of ototoxicity from discontinuation of treatment onwards in a national cohort of platinum-treated survivors with hearing loss at the end of cancer treatment. Of the 168 CCS with follow-up audiograms, we longitudinally evaluated the course of hearing function in 61 CCS who showed hearing impairment at discontinuation of treatment according to the Münster criteria (>20 dB at ≥4–8 kHz). Survivors were treated with platinum (median total cumulative dose cisplatin: 480 mg/m2 and median total cumulative dose carboplatin: 2520 mg/m2). Median follow-up time was 5.5 years (range: 1.0–28.8 years). The results showed that none of these survivors revealed improvement of hearing function even till 28.8 years after discontinuation of treatment (grade <2b during long-term follow-up). An increase in hearing loss with two or three Münster degrees was observed in five of 61 survivors after 1.6–19.6 years. Overall, this indicates that ototoxicity after platinum treatment may be irreversible and that longitudinal clinical audiological monitoring and care is required in long-term survivors of childhood cancer on a large scale.
KW - Childhood cancer survivors
KW - cisplatin
KW - hearing loss
KW - late effects
KW - ototoxicity
UR - http://www.scopus.com/inward/record.url?scp=85020309000&partnerID=8YFLogxK
U2 - https://doi.org/10.1080/08880018.2017.1323985
DO - https://doi.org/10.1080/08880018.2017.1323985
M3 - Article
C2 - 28590156
SN - 0888-0018
VL - 34
SP - 120
EP - 129
JO - Pediatric Hematology and Oncology
JF - Pediatric Hematology and Oncology
IS - 2
ER -