Hearing loss due to concurrent daily low-dose cisplatin chemoradiation for locally advanced head and neck cancer

Charlotte L. Zuur; Yvonne J. W. Simis; Roxanna S. Verkaik; Jan H. Schornagel; Alfons J. M. Balm; Wouter A. Dreschler; Coen R. N. Rasch

doi:https://doi.org/10.1016/j.radonc.2008.06.003

Hearing loss due to concurrent daily low-dose cisplatin chemoradiation for locally advanced head and neck cancer

Charlotte L. Zuur, Yvonne J. W. Simis, Roxanna S. Verkaik, Jan H. Schornagel, Alfons J. M. Balm, Wouter A. Dreschler, Coen R. N. Rasch

Research output: Contribution to journal › Article › Academic › peer-review

43 Citations (Scopus)

Abstract

Background and purpose: Cisplatin-based chemo-irradiation (CRT) is increasingly used for head and neck squamous cell carcinoma (HNSCC). We aimed to assess hearing deterioration due to low-dose cisplatin chemoradiation and to compare the observed hearing loss with hearing loss in our previously described high-dose cisplatin CRT cohort. Materials and methods: A prospective analysis of hearing thresholds at low and (ultra)-high frequencies obtained before and after treatment in 60 patients. Patients received low-dose cisplatin (6 mg/m(2), daily infusions, 20-25 days) with concomitant accelerated radiotherapy (70 Gy). Results: Audiometry up to 16 kHz was performed before therapy and 31 days (median) post-treatment. The total incidence of ototoxicity in CTCAEv3.0 was 31% in audiograms up to 8 kHz, and 5% of ears tested qualified for HAs due to treatment. The mean hearing loss at speech frequencies was 2.6 dB (SD 5.7) and 2.3 dB (SD 9.2) at PTA 1-2-4 kHz air-conduction and bone-conduction, respectively. The mean hearing loss at ultra-high frequencies (PTA AC 8-10-12.5 kHz) was 9.0 dB (SD 8.1). Low-dose cisplatin CRT caused less acute hearing loss (CTCAE 31%), compared to high-dose cisplatin CRT (CTCAE 78%). Conclusions: Low-dose cisplatin chemo-irradiation for HNSCC is a relatively safe treatment protocol with respect to ototoxicity. Crown copyright (C) 2008 Published by Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 89 (2008) 38-43

Original language	English
Pages (from-to)	38-43
Journal	Radiotherapy and oncology
Volume	89
Issue number	1
DOIs	https://doi.org/10.1016/j.radonc.2008.06.003
Publication status	Published - 2008

Access to Document

https://doi.org/10.1016/j.radonc.2008.06.003

Cite this

@article{fa2799676d97470ca42cc0e40828350f,

title = "Hearing loss due to concurrent daily low-dose cisplatin chemoradiation for locally advanced head and neck cancer",

abstract = "Background and purpose: Cisplatin-based chemo-irradiation (CRT) is increasingly used for head and neck squamous cell carcinoma (HNSCC). We aimed to assess hearing deterioration due to low-dose cisplatin chemoradiation and to compare the observed hearing loss with hearing loss in our previously described high-dose cisplatin CRT cohort. Materials and methods: A prospective analysis of hearing thresholds at low and (ultra)-high frequencies obtained before and after treatment in 60 patients. Patients received low-dose cisplatin (6 mg/m(2), daily infusions, 20-25 days) with concomitant accelerated radiotherapy (70 Gy). Results: Audiometry up to 16 kHz was performed before therapy and 31 days (median) post-treatment. The total incidence of ototoxicity in CTCAEv3.0 was 31% in audiograms up to 8 kHz, and 5% of ears tested qualified for HAs due to treatment. The mean hearing loss at speech frequencies was 2.6 dB (SD 5.7) and 2.3 dB (SD 9.2) at PTA 1-2-4 kHz air-conduction and bone-conduction, respectively. The mean hearing loss at ultra-high frequencies (PTA AC 8-10-12.5 kHz) was 9.0 dB (SD 8.1). Low-dose cisplatin CRT caused less acute hearing loss (CTCAE 31%), compared to high-dose cisplatin CRT (CTCAE 78%). Conclusions: Low-dose cisplatin chemo-irradiation for HNSCC is a relatively safe treatment protocol with respect to ototoxicity. Crown copyright (C) 2008 Published by Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 89 (2008) 38-43",

author = "Zuur, {Charlotte L.} and Simis, {Yvonne J. W.} and Verkaik, {Roxanna S.} and Schornagel, {Jan H.} and Balm, {Alfons J. M.} and Dreschler, {Wouter A.} and Rasch, {Coen R. N.}",

year = "2008",

doi = "https://doi.org/10.1016/j.radonc.2008.06.003",

language = "English",

volume = "89",

pages = "38--43",

journal = "Radiotherapy and oncology",

issn = "0167-8140",

publisher = "Elsevier Ireland Ltd",

number = "1",

}

TY - JOUR

T1 - Hearing loss due to concurrent daily low-dose cisplatin chemoradiation for locally advanced head and neck cancer

AU - Zuur, Charlotte L.

AU - Simis, Yvonne J. W.

AU - Verkaik, Roxanna S.

AU - Schornagel, Jan H.

AU - Balm, Alfons J. M.

AU - Dreschler, Wouter A.

AU - Rasch, Coen R. N.

PY - 2008

Y1 - 2008

N2 - Background and purpose: Cisplatin-based chemo-irradiation (CRT) is increasingly used for head and neck squamous cell carcinoma (HNSCC). We aimed to assess hearing deterioration due to low-dose cisplatin chemoradiation and to compare the observed hearing loss with hearing loss in our previously described high-dose cisplatin CRT cohort. Materials and methods: A prospective analysis of hearing thresholds at low and (ultra)-high frequencies obtained before and after treatment in 60 patients. Patients received low-dose cisplatin (6 mg/m(2), daily infusions, 20-25 days) with concomitant accelerated radiotherapy (70 Gy). Results: Audiometry up to 16 kHz was performed before therapy and 31 days (median) post-treatment. The total incidence of ototoxicity in CTCAEv3.0 was 31% in audiograms up to 8 kHz, and 5% of ears tested qualified for HAs due to treatment. The mean hearing loss at speech frequencies was 2.6 dB (SD 5.7) and 2.3 dB (SD 9.2) at PTA 1-2-4 kHz air-conduction and bone-conduction, respectively. The mean hearing loss at ultra-high frequencies (PTA AC 8-10-12.5 kHz) was 9.0 dB (SD 8.1). Low-dose cisplatin CRT caused less acute hearing loss (CTCAE 31%), compared to high-dose cisplatin CRT (CTCAE 78%). Conclusions: Low-dose cisplatin chemo-irradiation for HNSCC is a relatively safe treatment protocol with respect to ototoxicity. Crown copyright (C) 2008 Published by Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 89 (2008) 38-43

AB - Background and purpose: Cisplatin-based chemo-irradiation (CRT) is increasingly used for head and neck squamous cell carcinoma (HNSCC). We aimed to assess hearing deterioration due to low-dose cisplatin chemoradiation and to compare the observed hearing loss with hearing loss in our previously described high-dose cisplatin CRT cohort. Materials and methods: A prospective analysis of hearing thresholds at low and (ultra)-high frequencies obtained before and after treatment in 60 patients. Patients received low-dose cisplatin (6 mg/m(2), daily infusions, 20-25 days) with concomitant accelerated radiotherapy (70 Gy). Results: Audiometry up to 16 kHz was performed before therapy and 31 days (median) post-treatment. The total incidence of ototoxicity in CTCAEv3.0 was 31% in audiograms up to 8 kHz, and 5% of ears tested qualified for HAs due to treatment. The mean hearing loss at speech frequencies was 2.6 dB (SD 5.7) and 2.3 dB (SD 9.2) at PTA 1-2-4 kHz air-conduction and bone-conduction, respectively. The mean hearing loss at ultra-high frequencies (PTA AC 8-10-12.5 kHz) was 9.0 dB (SD 8.1). Low-dose cisplatin CRT caused less acute hearing loss (CTCAE 31%), compared to high-dose cisplatin CRT (CTCAE 78%). Conclusions: Low-dose cisplatin chemo-irradiation for HNSCC is a relatively safe treatment protocol with respect to ototoxicity. Crown copyright (C) 2008 Published by Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 89 (2008) 38-43

U2 - https://doi.org/10.1016/j.radonc.2008.06.003

DO - https://doi.org/10.1016/j.radonc.2008.06.003

M3 - Article

C2 - 18706728

SN - 0167-8140

VL - 89

SP - 38

EP - 43

JO - Radiotherapy and oncology

JF - Radiotherapy and oncology

IS - 1

ER -