Helicobacter pylori phase variation, immune modulation and gastric autoimmunity

Mathijs Bergman; Gianfranco Del Prete; Yvette van Kooyk; Ben Appelmelk

doi:https://doi.org/10.1038/nrmicro1344

Helicobacter pylori phase variation, immune modulation and gastric autoimmunity

Mathijs Bergman, Gianfranco Del Prete, Yvette van Kooyk, Ben Appelmelk

Research output: Contribution to journal › Review article › Academic › peer-review

87 Citations (Scopus)

Abstract

Helicobacter pylori can be regarded as a model pathogen for studying persistent colonization of humans. Phase-variable expression of Lewis blood-group antigens by H. pylori allows this microorganism to modulate the host T-helper-1-cell versus T-helper-2-cell response. We describe a model in which interactions between host lectins and pathogen carbohydrates facilitate asymptomatic persistence of H. pylori. This delicate balance, favourable for both the pathogen and the host, could lead to gastric autoimmunity in genetically susceptible individuals.

Original language	English
Pages (from-to)	151-9
Number of pages	9
Journal	Critical reviews in microbiology
Volume	4
Issue number	2
DOIs	https://doi.org/10.1038/nrmicro1344
Publication status	Published - Feb 2006

Keywords

Amino Acid Sequence
Autoimmunity
Genetic Predisposition to Disease
Helicobacter Infections/genetics
Helicobacter pylori/immunology
Humans
Molecular Sequence Data
Stomach Diseases/genetics

Access to Document

https://doi.org/10.1038/nrmicro1344

Cite this

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title = "Helicobacter pylori phase variation, immune modulation and gastric autoimmunity",

abstract = "Helicobacter pylori can be regarded as a model pathogen for studying persistent colonization of humans. Phase-variable expression of Lewis blood-group antigens by H. pylori allows this microorganism to modulate the host T-helper-1-cell versus T-helper-2-cell response. We describe a model in which interactions between host lectins and pathogen carbohydrates facilitate asymptomatic persistence of H. pylori. This delicate balance, favourable for both the pathogen and the host, could lead to gastric autoimmunity in genetically susceptible individuals.",

keywords = "Amino Acid Sequence, Autoimmunity, Genetic Predisposition to Disease, Helicobacter Infections/genetics, Helicobacter pylori/immunology, Humans, Molecular Sequence Data, Stomach Diseases/genetics",

author = "Mathijs Bergman and {Del Prete}, Gianfranco and {van Kooyk}, Yvette and Ben Appelmelk",

year = "2006",

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doi = "https://doi.org/10.1038/nrmicro1344",

language = "English",

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T1 - Helicobacter pylori phase variation, immune modulation and gastric autoimmunity

AU - Bergman, Mathijs

AU - Del Prete, Gianfranco

AU - van Kooyk, Yvette

AU - Appelmelk, Ben

PY - 2006/2

Y1 - 2006/2

N2 - Helicobacter pylori can be regarded as a model pathogen for studying persistent colonization of humans. Phase-variable expression of Lewis blood-group antigens by H. pylori allows this microorganism to modulate the host T-helper-1-cell versus T-helper-2-cell response. We describe a model in which interactions between host lectins and pathogen carbohydrates facilitate asymptomatic persistence of H. pylori. This delicate balance, favourable for both the pathogen and the host, could lead to gastric autoimmunity in genetically susceptible individuals.

AB - Helicobacter pylori can be regarded as a model pathogen for studying persistent colonization of humans. Phase-variable expression of Lewis blood-group antigens by H. pylori allows this microorganism to modulate the host T-helper-1-cell versus T-helper-2-cell response. We describe a model in which interactions between host lectins and pathogen carbohydrates facilitate asymptomatic persistence of H. pylori. This delicate balance, favourable for both the pathogen and the host, could lead to gastric autoimmunity in genetically susceptible individuals.

KW - Amino Acid Sequence

KW - Autoimmunity

KW - Genetic Predisposition to Disease

KW - Helicobacter Infections/genetics

KW - Helicobacter pylori/immunology

KW - Humans

KW - Molecular Sequence Data

KW - Stomach Diseases/genetics

U2 - https://doi.org/10.1038/nrmicro1344

DO - https://doi.org/10.1038/nrmicro1344

M3 - Review article

C2 - 16415930

SN - 1740-1526

VL - 4

SP - 151

EP - 159

JO - Critical reviews in microbiology

JF - Critical reviews in microbiology

IS - 2

ER -