Helminth-Induced IgE and Protection Against Allergic Disorders

Firdaus Hamid; Abena S. Amoah; Ronald van Ree; Maria Yazdanbakhsh

doi:https://doi.org/10.1007/978-3-319-13725-4_5

Helminth-Induced IgE and Protection Against Allergic Disorders

Firdaus Hamid, Abena S. Amoah, Ronald van Ree, Maria Yazdanbakhsh

Research output: Contribution to journal › Review article › Academic › peer-review

20 Citations (Scopus)

Abstract

The immune response against helminths and allergens is generally characterized by high levels of IgE and increased numbers of Th2 cells, eosinophils, and mast cells, yet the clinical outcome with respect to immediate hypersensitivity and inflammation is clearly not the same. High levels of IgE are seen to allergens during helminth infections; however, these IgE responses do not translate into allergy symptoms. This chapter summarizes the evidence of the association between helminth infections and allergic disorders. It discusses how helminth infection can lead to IgE cross-reactivity with allergens and how this IgE has poor biological activity. This information is important for developing new diagnostic methods and treatments for allergic disorders in low-to-middle-income countries

Original language	English
Pages (from-to)	91-108
Journal	Current topics in microbiology and immunology
Volume	388
DOIs	https://doi.org/10.1007/978-3-319-13725-4_5
Publication status	Published - 2015

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https://doi.org/10.1007/978-3-319-13725-4_5

Cite this

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title = "Helminth-Induced IgE and Protection Against Allergic Disorders",

abstract = "The immune response against helminths and allergens is generally characterized by high levels of IgE and increased numbers of Th2 cells, eosinophils, and mast cells, yet the clinical outcome with respect to immediate hypersensitivity and inflammation is clearly not the same. High levels of IgE are seen to allergens during helminth infections; however, these IgE responses do not translate into allergy symptoms. This chapter summarizes the evidence of the association between helminth infections and allergic disorders. It discusses how helminth infection can lead to IgE cross-reactivity with allergens and how this IgE has poor biological activity. This information is important for developing new diagnostic methods and treatments for allergic disorders in low-to-middle-income countries",

author = "Firdaus Hamid and Amoah, {Abena S.} and {van Ree}, Ronald and Maria Yazdanbakhsh",

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T1 - Helminth-Induced IgE and Protection Against Allergic Disorders

AU - Hamid, Firdaus

AU - Amoah, Abena S.

AU - van Ree, Ronald

AU - Yazdanbakhsh, Maria

PY - 2015

Y1 - 2015

N2 - The immune response against helminths and allergens is generally characterized by high levels of IgE and increased numbers of Th2 cells, eosinophils, and mast cells, yet the clinical outcome with respect to immediate hypersensitivity and inflammation is clearly not the same. High levels of IgE are seen to allergens during helminth infections; however, these IgE responses do not translate into allergy symptoms. This chapter summarizes the evidence of the association between helminth infections and allergic disorders. It discusses how helminth infection can lead to IgE cross-reactivity with allergens and how this IgE has poor biological activity. This information is important for developing new diagnostic methods and treatments for allergic disorders in low-to-middle-income countries

AB - The immune response against helminths and allergens is generally characterized by high levels of IgE and increased numbers of Th2 cells, eosinophils, and mast cells, yet the clinical outcome with respect to immediate hypersensitivity and inflammation is clearly not the same. High levels of IgE are seen to allergens during helminth infections; however, these IgE responses do not translate into allergy symptoms. This chapter summarizes the evidence of the association between helminth infections and allergic disorders. It discusses how helminth infection can lead to IgE cross-reactivity with allergens and how this IgE has poor biological activity. This information is important for developing new diagnostic methods and treatments for allergic disorders in low-to-middle-income countries

U2 - https://doi.org/10.1007/978-3-319-13725-4_5

DO - https://doi.org/10.1007/978-3-319-13725-4_5

M3 - Review article

C2 - 25553796

SN - 0070-217X

VL - 388

SP - 91

EP - 108

JO - Current topics in microbiology and immunology

JF - Current topics in microbiology and immunology

ER -