Hematopoietic system-specific antigens as targets for cellular immunotherapy of hematological malignancies

Tuna Mutis, Els Goulmy

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57 Citations (Scopus)


Allogeneic stem cell transplantation (SCT) is the treatment of choice for many hematological malignancies. Its curative graft-versus-leukemia (GvL) effect is mainly mediated by donor-derived alloreactive T cells. However, if the donor T cells are not selected for their reactivity against leukemic cells, the GvL effect is often associated with graft-versus-host disease (GvHD), a major complication of SCT. Here we summarize our current knowledge on leukemia-associated antigens and discuss strategies to apply minor and major histocompatibility antigens for cellular immunotherapy of hematological malignancies with a low risk of GvHD.

Original languageEnglish
Pages (from-to)23-31
Number of pages9
JournalSeminars in Hematology
Issue number1
Publication statusPublished - 1 Jan 2002

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