Heritability of menopausal age in mothers and daughters

Kristel M. van Asselt; Helen S. Kok; Peter L. Pearson; Judith S. Dubas; Petra H. M. Peeters; Egbert R. te Velde; Paulus A. H. van Noord

doi:https://doi.org/10.1016/j.fertnstert.2004.04.047

Heritability of menopausal age in mothers and daughters

Kristel M. van Asselt, Helen S. Kok, Peter L. Pearson, Judith S. Dubas, Petra H. M. Peeters, Egbert R. te Velde, Paulus A. H. van Noord

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Abstract

Objective: To determine the heritability of age at natural menopause from mother-daughter pairs. Design: Two-generation families were selected to study heritability of menopausal age. Setting: Subjects were drawn from a population-based study. Patient(s): One hundred sixty-four mother-daughter pairs with a natural menopausal age. Intervention(s): None. Main Outcome Measure(s): The heritability of age at natural menopause estimated by a random-effects model. Result(s): A heritability of 44% (95% confidence interval, 36%, 50%) was estimated. Conclusion(s): This study confirms that heritable components largely determine the natural age at menopause. Reasons for the differences between heritability estimates based on sibling pairs and parent-child comparisons are discussed. (C) 2004 by American Society for Reproductive Medicine

Original language	English
Pages (from-to)	1348-1351
Journal	Fertility and Sterility
Volume	82
Issue number	5
DOIs	https://doi.org/10.1016/j.fertnstert.2004.04.047
Publication status	Published - 2004

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https://doi.org/10.1016/j.fertnstert.2004.04.047

Cite this

@article{3a23209f6b644ecf9287b91716987ae3,

title = "Heritability of menopausal age in mothers and daughters",

abstract = "Objective: To determine the heritability of age at natural menopause from mother-daughter pairs. Design: Two-generation families were selected to study heritability of menopausal age. Setting: Subjects were drawn from a population-based study. Patient(s): One hundred sixty-four mother-daughter pairs with a natural menopausal age. Intervention(s): None. Main Outcome Measure(s): The heritability of age at natural menopause estimated by a random-effects model. Result(s): A heritability of 44% (95% confidence interval, 36%, 50%) was estimated. Conclusion(s): This study confirms that heritable components largely determine the natural age at menopause. Reasons for the differences between heritability estimates based on sibling pairs and parent-child comparisons are discussed. (C) 2004 by American Society for Reproductive Medicine",

author = "{van Asselt}, {Kristel M.} and Kok, {Helen S.} and Pearson, {Peter L.} and Dubas, {Judith S.} and Peeters, {Petra H. M.} and {te Velde}, {Egbert R.} and {van Noord}, {Paulus A. H.}",

year = "2004",

doi = "https://doi.org/10.1016/j.fertnstert.2004.04.047",

language = "English",

volume = "82",

pages = "1348--1351",

journal = "Fertility and Sterility",

issn = "0015-0282",

publisher = "Elsevier Inc.",

number = "5",

}

TY - JOUR

T1 - Heritability of menopausal age in mothers and daughters

AU - van Asselt, Kristel M.

AU - Kok, Helen S.

AU - Pearson, Peter L.

AU - Dubas, Judith S.

AU - Peeters, Petra H. M.

AU - te Velde, Egbert R.

AU - van Noord, Paulus A. H.

PY - 2004

Y1 - 2004

N2 - Objective: To determine the heritability of age at natural menopause from mother-daughter pairs. Design: Two-generation families were selected to study heritability of menopausal age. Setting: Subjects were drawn from a population-based study. Patient(s): One hundred sixty-four mother-daughter pairs with a natural menopausal age. Intervention(s): None. Main Outcome Measure(s): The heritability of age at natural menopause estimated by a random-effects model. Result(s): A heritability of 44% (95% confidence interval, 36%, 50%) was estimated. Conclusion(s): This study confirms that heritable components largely determine the natural age at menopause. Reasons for the differences between heritability estimates based on sibling pairs and parent-child comparisons are discussed. (C) 2004 by American Society for Reproductive Medicine

AB - Objective: To determine the heritability of age at natural menopause from mother-daughter pairs. Design: Two-generation families were selected to study heritability of menopausal age. Setting: Subjects were drawn from a population-based study. Patient(s): One hundred sixty-four mother-daughter pairs with a natural menopausal age. Intervention(s): None. Main Outcome Measure(s): The heritability of age at natural menopause estimated by a random-effects model. Result(s): A heritability of 44% (95% confidence interval, 36%, 50%) was estimated. Conclusion(s): This study confirms that heritable components largely determine the natural age at menopause. Reasons for the differences between heritability estimates based on sibling pairs and parent-child comparisons are discussed. (C) 2004 by American Society for Reproductive Medicine

U2 - https://doi.org/10.1016/j.fertnstert.2004.04.047

DO - https://doi.org/10.1016/j.fertnstert.2004.04.047

M3 - Article

C2 - 15533358

SN - 0015-0282

VL - 82

SP - 1348

EP - 1351

JO - Fertility and Sterility

JF - Fertility and Sterility

IS - 5

ER -