Herpes simplex virus type 1 and normal protein permeability in the lungs of critically ill patients: a case for low pathogenicity?: a case for low pathogenicity?

J. Verheij; A.B.J. Groeneveld; A. Beishuizen; A. van Lingen; A.M. Simoons-Smit; RJ Strack van Schijndel; Rob J.M.Strack van Schijndel

doi:10.1186/cc2850

Herpes simplex virus type 1 and normal protein permeability in the lungs of critically ill patients: a case for low pathogenicity? a case for low pathogenicity?

J. Verheij, A.B.J. Groeneveld, A. Beishuizen, A. van Lingen, A.M. Simoons-Smit, RJ Strack van Schijndel, Rob J.M.Strack van Schijndel

Research output: Contribution to journal › Article › Academic › peer-review

12 Citations (Scopus)

Abstract

INTRODUCTION: The pathogenicity of late respiratory infections with herpes simplex virus type 1 (HSV-1) in the critically ill is unclear.

METHODS: In four critically ill patients with persistent pulmonary infiltrates of unknown origin and isolation of HSV-1 from tracheal aspirate or bronchoalveolar lavage fluid, at 7 (1-11) days after start of mechanical ventilatory support, a pulmonary leak index (PLI) for 67Gallium (67Ga)-transferrin (upper limit of normal 14.1 x 10(-3)/min) was measured.

RESULTS: The PLI ranged between 7.5 and 14.0 x 10(-3)/min in the study patients. Two patients received a course of acyclovir and all survived.

CONCLUSIONS: The normal capillary permeability observed in the lungs argues against pathogenicity of HSV-1 in the critically ill, and favors that isolation of the virus reflects reactivation in the course of serious illness and immunodepresssion, rather than primary or superimposed infection in the lungs.

Original language	English
Pages (from-to)	R139-R144
Journal	Critical Care
Volume	8
Issue number	3
DOIs	https://doi.org/10.1186/cc2850
Publication status	Published - Jun 2004

Keywords

Adult
Aged
Antiviral Agents/therapeutic use
Bronchoalveolar Lavage Fluid/virology
Capillary Permeability
Critical Illness
Female
Gallium Radioisotopes/pharmacokinetics
Herpesvirus 1, Human/isolation & purification
Humans
Male
Middle Aged
Organometallic Compounds/pharmacokinetics
Pneumonia, Viral/blood
Respiration, Artificial
Respiratory Distress Syndrome/blood
Transferrin/pharmacokinetics
Virulence
Virus Activation

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10.1186/cc2850

https://research.vumc.nl/ws/files/10001016/PMC468896

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Verheij, J., Groeneveld, A. B. J., Beishuizen, A., van Lingen, A., Simoons-Smit, A. M., Strack van Schijndel, RJ., & van Schijndel, R. J. M. S. (2004). Herpes simplex virus type 1 and normal protein permeability in the lungs of critically ill patients: a case for low pathogenicity? a case for low pathogenicity? Critical Care, 8(3), R139-R144. https://doi.org/10.1186/cc2850

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title = "Herpes simplex virus type 1 and normal protein permeability in the lungs of critically ill patients: a case for low pathogenicity?: a case for low pathogenicity?",

abstract = "INTRODUCTION: The pathogenicity of late respiratory infections with herpes simplex virus type 1 (HSV-1) in the critically ill is unclear.METHODS: In four critically ill patients with persistent pulmonary infiltrates of unknown origin and isolation of HSV-1 from tracheal aspirate or bronchoalveolar lavage fluid, at 7 (1-11) days after start of mechanical ventilatory support, a pulmonary leak index (PLI) for 67Gallium (67Ga)-transferrin (upper limit of normal 14.1 x 10(-3)/min) was measured.RESULTS: The PLI ranged between 7.5 and 14.0 x 10(-3)/min in the study patients. Two patients received a course of acyclovir and all survived.CONCLUSIONS: The normal capillary permeability observed in the lungs argues against pathogenicity of HSV-1 in the critically ill, and favors that isolation of the virus reflects reactivation in the course of serious illness and immunodepresssion, rather than primary or superimposed infection in the lungs.",

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author = "J. Verheij and A.B.J. Groeneveld and A. Beishuizen and {van Lingen}, A. and A.M. Simoons-Smit and {Strack van Schijndel}, RJ and {van Schijndel}, {Rob J.M.Strack}",

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doi = "10.1186/cc2850",

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AU - Groeneveld, A.B.J.

AU - Beishuizen, A.

AU - van Lingen, A.

AU - Simoons-Smit, A.M.

AU - Strack van Schijndel, RJ

AU - van Schijndel, Rob J.M.Strack

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N2 - INTRODUCTION: The pathogenicity of late respiratory infections with herpes simplex virus type 1 (HSV-1) in the critically ill is unclear.METHODS: In four critically ill patients with persistent pulmonary infiltrates of unknown origin and isolation of HSV-1 from tracheal aspirate or bronchoalveolar lavage fluid, at 7 (1-11) days after start of mechanical ventilatory support, a pulmonary leak index (PLI) for 67Gallium (67Ga)-transferrin (upper limit of normal 14.1 x 10(-3)/min) was measured.RESULTS: The PLI ranged between 7.5 and 14.0 x 10(-3)/min in the study patients. Two patients received a course of acyclovir and all survived.CONCLUSIONS: The normal capillary permeability observed in the lungs argues against pathogenicity of HSV-1 in the critically ill, and favors that isolation of the virus reflects reactivation in the course of serious illness and immunodepresssion, rather than primary or superimposed infection in the lungs.

AB - INTRODUCTION: The pathogenicity of late respiratory infections with herpes simplex virus type 1 (HSV-1) in the critically ill is unclear.METHODS: In four critically ill patients with persistent pulmonary infiltrates of unknown origin and isolation of HSV-1 from tracheal aspirate or bronchoalveolar lavage fluid, at 7 (1-11) days after start of mechanical ventilatory support, a pulmonary leak index (PLI) for 67Gallium (67Ga)-transferrin (upper limit of normal 14.1 x 10(-3)/min) was measured.RESULTS: The PLI ranged between 7.5 and 14.0 x 10(-3)/min in the study patients. Two patients received a course of acyclovir and all survived.CONCLUSIONS: The normal capillary permeability observed in the lungs argues against pathogenicity of HSV-1 in the critically ill, and favors that isolation of the virus reflects reactivation in the course of serious illness and immunodepresssion, rather than primary or superimposed infection in the lungs.

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Herpes simplex virus type 1 and normal protein permeability in the lungs of critically ill patients: a case for low pathogenicity? a case for low pathogenicity?

Abstract

Keywords

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