Abstract
Objectives: The 2015 Workshop of the Society for Hematopathology/European Association for Haematopathology aimed to review immunodeficiency-related lymphoproliferative disorders with plasmablastic and plasma cell differentiation.
Methods: The workshop panel reviewed human herpes virus 8 (HHV8)/Kaposi sarcoma herpesvirus (KSHV)-associated lesions and other lesions exhibiting plasma cell differentiation, including plasmablastic proliferations with features of myeloma/plasmacytoma, plasmablastic neoplasms presenting in extranodal sites and effusion-based lymphomas, and rendered a consensus diagnosis.
Results: The spectrum of HHV8/KSHV-associated proliferations ranged from multicentric Castleman disease (MCD) to MCD with plasmablastic aggregates to HHV8+ diffuse large B-cell lymphoma and germinotrophic lymphoproliferative disorder. Comparisons across effusion-based lymphomas with and without HHV8/KSHV and plasmablastic lymphomas in immunodeficient and immunocompetent patients were discussed.
Conclusions: The presence or absence of HHV8/KSHV is a defining feature in disorders associated with Castleman disease, although their differential diagnosis and recognition of progression may be challenging. Plasmablastic proliferations overlap with myeloma/plasmacytoma as well as extranodal and effusion-based lymphomas. The involvement of Epstein-Barr virus is typically variable.
Original language | English |
---|---|
Pages (from-to) | 171-187 |
Number of pages | 17 |
Journal | American Journal of Clinical Pathology |
Volume | 147 |
Issue number | 2 |
DOIs | |
Publication status | Published - 1 Feb 2017 |
Keywords
- Adult
- Aged
- Education
- Female
- Herpesviridae Infections
- Herpesvirus 8, Human
- Humans
- Immunologic Deficiency Syndromes
- Journal Article
- Lymphoproliferative Disorders
- Male
- Middle Aged
- Neoplasms, Plasma Cell