High factor VIII plasma levels as a risk factor for venous thrombosis: no evidence of inheritance from a family cohort study

Eduard J. Libourel; Corine P. Baljé-Volkers Degrees; Karly Hamulyàk; Martin H. Prins; Saskia Middeldorp; Harry R. Büller; Jan van der Meer

High factor VIII plasma levels as a risk factor for venous thrombosis: no evidence of inheritance from a family cohort study

Eduard J. Libourel, Corine P. Baljé-Volkers Degrees, Karly Hamulyàk, Martin H. Prins, Saskia Middeldorp, Harry R. Büller, Jan van der Meer

Vascular Medicine (AMC)

Research output: Contribution to journal › Comment/Letter to the editor › Academic

2 Citations (Scopus)

Abstract

We assessed inheritance of high factor VIII:C (FVIII:C greater than or equal to150%) levels in 52 probands carrying factor V Leiden and 176 first-degree relatives. Although age-adjusted FVIII:C levels aggregated within families, relatives of probands with FVIII:C levels greater than or equal to150% and <150% were comparable regarding median FVIII:C levels, cumulative distribution curves, and annual incidence of venous thromboembolism. Aggregation of high FVIII:C levels could not be explained by inheritance and was not predictable from FVIII:C levels in probands

Original language	English
Pages (from-to)	118-120
Journal	Haematologica
Volume	89
Issue number	1
Publication status	Published - 2004

Cite this

@article{14db6ff0771b4401a563d17a0446ee9d,

title = "High factor VIII plasma levels as a risk factor for venous thrombosis: no evidence of inheritance from a family cohort study",

abstract = "We assessed inheritance of high factor VIII:C (FVIII:C greater than or equal to150%) levels in 52 probands carrying factor V Leiden and 176 first-degree relatives. Although age-adjusted FVIII:C levels aggregated within families, relatives of probands with FVIII:C levels greater than or equal to150% and <150% were comparable regarding median FVIII:C levels, cumulative distribution curves, and annual incidence of venous thromboembolism. Aggregation of high FVIII:C levels could not be explained by inheritance and was not predictable from FVIII:C levels in probands",

author = "Libourel, {Eduard J.} and {Balj{\'e}-Volkers Degrees}, {Corine P.} and Karly Hamuly{\`a}k and Prins, {Martin H.} and Saskia Middeldorp and B{\"u}ller, {Harry R.} and {van der Meer}, Jan",

year = "2004",

language = "English",

volume = "89",

pages = "118--120",

journal = "Haematologica",

issn = "0390-6078",

publisher = "Ferrata Storti Foundation",

number = "1",

}

TY - JOUR

T1 - High factor VIII plasma levels as a risk factor for venous thrombosis: no evidence of inheritance from a family cohort study

AU - Libourel, Eduard J.

AU - Baljé-Volkers Degrees, Corine P.

AU - Hamulyàk, Karly

AU - Prins, Martin H.

AU - Middeldorp, Saskia

AU - Büller, Harry R.

AU - van der Meer, Jan

PY - 2004

Y1 - 2004

N2 - We assessed inheritance of high factor VIII:C (FVIII:C greater than or equal to150%) levels in 52 probands carrying factor V Leiden and 176 first-degree relatives. Although age-adjusted FVIII:C levels aggregated within families, relatives of probands with FVIII:C levels greater than or equal to150% and <150% were comparable regarding median FVIII:C levels, cumulative distribution curves, and annual incidence of venous thromboembolism. Aggregation of high FVIII:C levels could not be explained by inheritance and was not predictable from FVIII:C levels in probands

AB - We assessed inheritance of high factor VIII:C (FVIII:C greater than or equal to150%) levels in 52 probands carrying factor V Leiden and 176 first-degree relatives. Although age-adjusted FVIII:C levels aggregated within families, relatives of probands with FVIII:C levels greater than or equal to150% and <150% were comparable regarding median FVIII:C levels, cumulative distribution curves, and annual incidence of venous thromboembolism. Aggregation of high FVIII:C levels could not be explained by inheritance and was not predictable from FVIII:C levels in probands

M3 - Comment/Letter to the editor

C2 - 14754621

SN - 0390-6078

VL - 89

SP - 118

EP - 120

JO - Haematologica

JF - Haematologica

IS - 1

ER -