TY - JOUR
T1 - High prevalence of Chlamydia trachomatis and Neisseria gonorrhoeae infections among HIV-1 negative men who have sex with men in coastal Kenya
AU - Sanders, E.J.
AU - Thiong’o, A.N.
AU - Okuku, H.S.
AU - Mwambi, J.
AU - Priddy, F.
AU - Shafi, J.
AU - de Vries, H.J.C.
AU - McClelland, R.S.
AU - Graham, S.M.
AU - Thiong'o, Alexander N.
PY - 2010
Y1 - 2010
N2 - Objectives To assess the burden of Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) in high-risk HIV-1 negative men who have sex with men (MSM) in Africa. Methods Before the start of a pre-exposure prophylaxis trial, HIV-1 negative volunteers were screened for sexually transmitted infection (STI) including CT and NO, using a highly sensitive and specific nucleic acid amplification test. Samples positive for CT by Aptima testing, were evaluated for the presence of lymphogranuloma venereum (LGV) serovars using an in-house PCR assay. All men were asked to submit a urine specimen, and all had a rectal swab collected by a clinician. Men were asked if they had dysuria, urethral or rectal discharge, or rectal pain. Results 43 HIV-1 negative MSM were screened, of whom 13 reported sex with men only: the majority (27/43) reported sex work, One volunteer had dysuria and another, rectal pain. Eleven MSM (26%, 95% Cl 14% to 41%) had infections with either or both pathogens. Homosexual men had a higher prevalence of any infection than bisexual men (46% vs 17%, p=0.04), and all cases of rectal infections, including one with CT, two with NO and two with CT/NG co-infection. All patients with CT were negative for LGV. One patient with a rectal NO infection reported rectal pain. Conclusions A remarkably high burden of STI infection was found among HIV-1 negative MSM. Most (12/13) infections, including three of four rectal NG infections, were subclinical. These findings suggest that high-risk MSM will benefit from effective STI screening in Kenya
AB - Objectives To assess the burden of Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) in high-risk HIV-1 negative men who have sex with men (MSM) in Africa. Methods Before the start of a pre-exposure prophylaxis trial, HIV-1 negative volunteers were screened for sexually transmitted infection (STI) including CT and NO, using a highly sensitive and specific nucleic acid amplification test. Samples positive for CT by Aptima testing, were evaluated for the presence of lymphogranuloma venereum (LGV) serovars using an in-house PCR assay. All men were asked to submit a urine specimen, and all had a rectal swab collected by a clinician. Men were asked if they had dysuria, urethral or rectal discharge, or rectal pain. Results 43 HIV-1 negative MSM were screened, of whom 13 reported sex with men only: the majority (27/43) reported sex work, One volunteer had dysuria and another, rectal pain. Eleven MSM (26%, 95% Cl 14% to 41%) had infections with either or both pathogens. Homosexual men had a higher prevalence of any infection than bisexual men (46% vs 17%, p=0.04), and all cases of rectal infections, including one with CT, two with NO and two with CT/NG co-infection. All patients with CT were negative for LGV. One patient with a rectal NO infection reported rectal pain. Conclusions A remarkably high burden of STI infection was found among HIV-1 negative MSM. Most (12/13) infections, including three of four rectal NG infections, were subclinical. These findings suggest that high-risk MSM will benefit from effective STI screening in Kenya
U2 - https://doi.org/10.1136/sti.2010.043224
DO - https://doi.org/10.1136/sti.2010.043224
M3 - Article
C2 - 20656722
SN - 1368-4973
VL - 86
SP - 440
EP - 441
JO - Sexually transmitted infections
JF - Sexually transmitted infections
IS - 6
ER -