TY - JOUR
T1 - High prevalence of microalbuminuria in chronic heart failure patients
AU - van de Wal, Ruud M. A.
AU - Asselbergs, Folkert W.
AU - Plokker, H. W. Thijs
AU - Smilde, Tom D. J.
AU - Lok, Dirk
AU - van Veldhuisen, Dirk J.
AU - van Gilst, Wiek H.
AU - Voors, Adriaan A.
PY - 2005/10
Y1 - 2005/10
N2 - Background: Microalbuminuria is associated with increased risk for cardiovascular morbidity and mortality. However, the relation between microalbuminuria and chronic heart failure has not been well described yet. In this cross-sectional study, we aim to evaluate the prevalence of microalbuminuria and the association with neurohormonal parameters in severe chronic heart failure patients. Methods and Results: We studied 94 stable chronic heart failure patients (New York Heart Association class III/IV) receiving therapy with angiotensin-converting enzyme (ACE) inhibitors for over three months. In all patients, renal function and neurohormonal status were evaluated and correlated with urinary albumin/creatinine ratio. The studied population consisted of 70 men and 21 women (mean age 69 ± 12 years). Ischemia was the underlying cause of heart failure in 61 patients. Overall, 100% of the patients were treated with an ACE inhibitor, 72% with a β-blocker, and 47% with spironolactone. In 32% (95% confidence interval 22-42) of the patients, microalbuminuria was present, which is significantly higher than in the general population. However, we found no significant association between the presence of microalbuminuria and renal function. Plasma NT-proBNP, active renin protein, angiotensin I, angiotensin II, and aldosterone did not differ significantly between groups with and without microalbuminuria. Conclusion: In 32% of the patients, microalbuminuria was present. No association was found with either renal or neurohormonal parameters. © 2005 Elsevier Inc. All rights reserved.
AB - Background: Microalbuminuria is associated with increased risk for cardiovascular morbidity and mortality. However, the relation between microalbuminuria and chronic heart failure has not been well described yet. In this cross-sectional study, we aim to evaluate the prevalence of microalbuminuria and the association with neurohormonal parameters in severe chronic heart failure patients. Methods and Results: We studied 94 stable chronic heart failure patients (New York Heart Association class III/IV) receiving therapy with angiotensin-converting enzyme (ACE) inhibitors for over three months. In all patients, renal function and neurohormonal status were evaluated and correlated with urinary albumin/creatinine ratio. The studied population consisted of 70 men and 21 women (mean age 69 ± 12 years). Ischemia was the underlying cause of heart failure in 61 patients. Overall, 100% of the patients were treated with an ACE inhibitor, 72% with a β-blocker, and 47% with spironolactone. In 32% (95% confidence interval 22-42) of the patients, microalbuminuria was present, which is significantly higher than in the general population. However, we found no significant association between the presence of microalbuminuria and renal function. Plasma NT-proBNP, active renin protein, angiotensin I, angiotensin II, and aldosterone did not differ significantly between groups with and without microalbuminuria. Conclusion: In 32% of the patients, microalbuminuria was present. No association was found with either renal or neurohormonal parameters. © 2005 Elsevier Inc. All rights reserved.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=26844443362&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/16230263
U2 - https://doi.org/10.1016/j.cardfail.2005.05.007
DO - https://doi.org/10.1016/j.cardfail.2005.05.007
M3 - Article
C2 - 16230263
SN - 1071-9164
VL - 11
SP - 602
EP - 606
JO - Journal of Cardiac Failure
JF - Journal of Cardiac Failure
IS - 8
ER -