Higher harmonics of vibrating gas-filled microspheres. Part one: simulations

N. de Jong; R. Cornet; C. T. Lancée

doi:https://doi.org/10.1016/0041-624X(94)90064-7

Higher harmonics of vibrating gas-filled microspheres. Part one: simulations

N. de Jong, R. Cornet, C. T. Lancée

Research output: Contribution to journal › Article › Academic › peer-review

335 Citations (Scopus)

Abstract

The acoustic behaviour of an ideal gas bubble in water is considered and the equation of motion is extended to model an Albunex microsphere. Calculations reveal large differences in non-linear behaviour between ideal gas bubbles and Albunex microspheres, due to the additional restoring force of, and friction inside, the shell that surrounds the Albunex microsphere. Simulations with the Albunex contrast agent further reveal that the optimal driving frequency is 1 MHz, resulting in a second harmonic that is 20 dB below the first harmonic at an acoustic pressure of 50 kPa. The difference increases to 25 dB for a driving frequency of 2 MHz.

Original language	English
Pages (from-to)	447-453
Number of pages	7
Journal	Ultrasonics
Volume	32
Issue number	6
DOIs	https://doi.org/10.1016/0041-624X(94)90064-7
Publication status	Published - Nov 1994

Keywords

Albunex microspheres
acoustic behaviour
contrast agent
gas bubbles
simulations
ultrasound

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https://doi.org/10.1016/0041-624X(94)90064-7

Cite this

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title = "Higher harmonics of vibrating gas-filled microspheres. Part one: simulations",

abstract = "The acoustic behaviour of an ideal gas bubble in water is considered and the equation of motion is extended to model an Albunex microsphere. Calculations reveal large differences in non-linear behaviour between ideal gas bubbles and Albunex microspheres, due to the additional restoring force of, and friction inside, the shell that surrounds the Albunex microsphere. Simulations with the Albunex contrast agent further reveal that the optimal driving frequency is 1 MHz, resulting in a second harmonic that is 20 dB below the first harmonic at an acoustic pressure of 50 kPa. The difference increases to 25 dB for a driving frequency of 2 MHz.",

keywords = "Albunex microspheres, acoustic behaviour, contrast agent, gas bubbles, simulations, ultrasound",

author = "{de Jong}, N. and R. Cornet and Lanc{\'e}e, {C. T.}",

note = "Funding Information: This study was sponsored by Nycomed Imaging AS, Oslo, Norway.",

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T1 - Higher harmonics of vibrating gas-filled microspheres. Part one

T2 - simulations

AU - de Jong, N.

AU - Cornet, R.

AU - Lancée, C. T.

N1 - Funding Information: This study was sponsored by Nycomed Imaging AS, Oslo, Norway.

PY - 1994/11

Y1 - 1994/11

N2 - The acoustic behaviour of an ideal gas bubble in water is considered and the equation of motion is extended to model an Albunex microsphere. Calculations reveal large differences in non-linear behaviour between ideal gas bubbles and Albunex microspheres, due to the additional restoring force of, and friction inside, the shell that surrounds the Albunex microsphere. Simulations with the Albunex contrast agent further reveal that the optimal driving frequency is 1 MHz, resulting in a second harmonic that is 20 dB below the first harmonic at an acoustic pressure of 50 kPa. The difference increases to 25 dB for a driving frequency of 2 MHz.

AB - The acoustic behaviour of an ideal gas bubble in water is considered and the equation of motion is extended to model an Albunex microsphere. Calculations reveal large differences in non-linear behaviour between ideal gas bubbles and Albunex microspheres, due to the additional restoring force of, and friction inside, the shell that surrounds the Albunex microsphere. Simulations with the Albunex contrast agent further reveal that the optimal driving frequency is 1 MHz, resulting in a second harmonic that is 20 dB below the first harmonic at an acoustic pressure of 50 kPa. The difference increases to 25 dB for a driving frequency of 2 MHz.

KW - Albunex microspheres

KW - acoustic behaviour

KW - contrast agent

KW - gas bubbles

KW - simulations

KW - ultrasound

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DO - https://doi.org/10.1016/0041-624X(94)90064-7

M3 - Article

SN - 0041-624X

VL - 32

SP - 447

EP - 453

JO - Ultrasonics

JF - Ultrasonics

IS - 6

ER -

Higher harmonics of vibrating gas-filled microspheres. Part one: simulations

Abstract

Keywords

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