TY - JOUR
T1 - Higher Mortality Despite Early Antiretroviral Therapy in Human Immunodeficiency Virus and Hepatitis B Virus (HBV)-Coinfected Patients with High HBV Replication
AU - Kouame, Gerard-Menan
AU - Boyd, Anders
AU - Moh, Raoul
AU - Badje, Anani
AU - Gabillard, Delphine
AU - Ouattara, Eric
AU - Ntakpe, Jean-Baptiste
AU - Emième, Arlette
AU - Maylin, Sarah
AU - Chekaraou, Mariama Abdou
AU - Eholieme, Serge-Paul
AU - Zoulim, Fabien
AU - Lacombe, Karine
AU - Anglaret, Xavier
AU - Danel, Christine
N1 - © The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - In human immunodeficiency virus (HIV).infected patients, hepatitis B virus (HBV) coinfection increases the risk of disease progression. Tenofovir plus emtricitabine/lamivudine (TDF/XTC).based antiretroviral therapy (ART), which suppresses HIV and HBV replication, has the potential for decreasing this risk. Here, we analyze the association between HBV replication, early ART, and mortality in West African adults. Methods. The Temprano randomized controlled trial assessed the benefits of immediately initiating vs deferring ART in HIVinfected adults with high CD4 counts. After trial completion, participants continued follow-up in a posttrial phase. We analyzed the association between HBV status, immediate ART, and mortality over the entire trial and posttrial follow-up using multivariable Cox proportional hazards regression. Results. A total of 2052 HIV-infected adults (median baseline CD4 count, 464 cells/ÊL) were followed for 9394 person-years. At baseline, 1862 (91%) were HIV monoinfected and 190 (9%) HIV/HBV coinfected. Of the latter, 135 (71%) had plasma HBV DNA >2000 IU/mL and 55 (29%) HBV DNA .2000 IU/mL. The 60-month probability of death was 11.8% (95% confidence interval [CI], 5.4%.24.5%) in coinfected patients with HBV DNA .2000 IU/mL; 4.4% (95% CI, 1.9%.10.4%) in coinfected patients with HBV DNA >2000 IU/mL; and 4.2% (95% CI, 3.3%.5.4%) in HIV-monoinfected patients. Adjusting for ART strategy (immediate vs deferred), the hazard ratio of death was 2.74 (95% CI, 1.26.5.97) in coinfected patients with HBV DNA .2000 IU/mL and 0.90 (95% CI, .36.2.24) in coinfected patients with HBV DNA >2000 IU/mL compared to HIV-monoinfected patients. There was no interaction between ART strategy and HBV status for mortality. Conclusions. African HIV/HBV-coinfected adults with high HBV replication remain at heightened risk of mortality in the early ART era. Further studies are needed to assess interventions combined with early ART to decrease mortality in this population.
AB - In human immunodeficiency virus (HIV).infected patients, hepatitis B virus (HBV) coinfection increases the risk of disease progression. Tenofovir plus emtricitabine/lamivudine (TDF/XTC).based antiretroviral therapy (ART), which suppresses HIV and HBV replication, has the potential for decreasing this risk. Here, we analyze the association between HBV replication, early ART, and mortality in West African adults. Methods. The Temprano randomized controlled trial assessed the benefits of immediately initiating vs deferring ART in HIVinfected adults with high CD4 counts. After trial completion, participants continued follow-up in a posttrial phase. We analyzed the association between HBV status, immediate ART, and mortality over the entire trial and posttrial follow-up using multivariable Cox proportional hazards regression. Results. A total of 2052 HIV-infected adults (median baseline CD4 count, 464 cells/ÊL) were followed for 9394 person-years. At baseline, 1862 (91%) were HIV monoinfected and 190 (9%) HIV/HBV coinfected. Of the latter, 135 (71%) had plasma HBV DNA >2000 IU/mL and 55 (29%) HBV DNA .2000 IU/mL. The 60-month probability of death was 11.8% (95% confidence interval [CI], 5.4%.24.5%) in coinfected patients with HBV DNA .2000 IU/mL; 4.4% (95% CI, 1.9%.10.4%) in coinfected patients with HBV DNA >2000 IU/mL; and 4.2% (95% CI, 3.3%.5.4%) in HIV-monoinfected patients. Adjusting for ART strategy (immediate vs deferred), the hazard ratio of death was 2.74 (95% CI, 1.26.5.97) in coinfected patients with HBV DNA .2000 IU/mL and 0.90 (95% CI, .36.2.24) in coinfected patients with HBV DNA >2000 IU/mL compared to HIV-monoinfected patients. There was no interaction between ART strategy and HBV status for mortality. Conclusions. African HIV/HBV-coinfected adults with high HBV replication remain at heightened risk of mortality in the early ART era. Further studies are needed to assess interventions combined with early ART to decrease mortality in this population.
KW - Adult
KW - Africa, Western
KW - Antiviral Agents/therapeutic use
KW - Coinfection/drug therapy
KW - DNA, Viral/blood
KW - Female
KW - HIV Infections/complications
KW - Hepatitis B virus/genetics
KW - Hepatitis B, Chronic/complications
KW - Humans
KW - Male
KW - Randomized Controlled Trials as Topic
KW - Secondary Prevention/methods
KW - Survival Analysis
KW - Viral Load
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85040583215&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/29020361
U2 - https://doi.org/10.1093/cid/cix747
DO - https://doi.org/10.1093/cid/cix747
M3 - Article
C2 - 29020361
SN - 1058-4838
VL - 66
SP - 112
EP - 120
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
IS - 1
ER -